Navigation Links
Scripps Wellderly Genome Resource now available to researchers
Date:3/6/2014

LA JOLLA, CALIF. Scientists exploring the genetic causes of illnesses such as Alzheimer's disease, heart disease, cancer and diabetes now have a new tool a reference DNA dataset built by researchers at Scripps Translational Science Institute (STSI).

STSI researchers announced the release of the Scripps Wellderly Genome Resource (SWGR) today at the Future of Genomic Medicine Conference, the institute's annual educational gathering of the nation's leading genetics experts.

The SWGR is comprised of the whole genome sequences of 454 participants in the Wellderly Study, an ongoing STSI research project that is searching for the genetic secrets behind lifelong health by looking at the genes of healthy elderly people.

What makes this dataset stand out from other genomic references is the exceptional healthspan of the Wellderly participants, who have lived at least 80 years without developing any chronic diseases. Since other reference genomes include DNA data from younger participants, there is no way of knowing whether their disease status will change later in life.

Because the SWGR contains information from a healthy population, it can serve as a control group for a wide range of genomic studies of most late-onset adult diseases.

"We hope the Scripps Wellderly Genome Resource will play an important role in providing the research community extensive genomic characterization of a vital phenotype healthspan which has not been previously available," said Eric Topol, M.D., director of STSI and chief academic officer of Scripps Health. "We will continue to build on this with diploid, phased genomes in larger numbers of our Wellderly cohort."

Scientists around the world can now access the SWGR free through the San Diego Supercomputer and the financial support of a National Institutes of Health Clinical and Translational Science Award.

"The Scripps Wellderly Genome Resource offers the genomics community a best-case scenario for the presence of a DNA variant in a population," said Erick Scott, M.D., a clinical scholar at STSI and doctoral student in the labs of Ali Torkamani and Peter G. Schultz at The Scripps Research Institute in San Diego. Scott led the effort to analyze the Wellderly Study data.

Researchers who tap into the Scripps dataset can use another tool developed by STSI called SG ADVISER. The free online search engine, located at genomics.scripps.edu/ADVISER/, delivers rich amounts of information about gene variants, including whether the searched-for variant appears in the Wellderly population and how frequently it shows up in that group.

The first published use of the SWGR came in January when a group of U.S. and U.K. researchers linked rare mutations of a certain gene to a twofold increase in the risk of developing late-onset Alzheimer's. The Scripps dataset served as a control for comparing members of 14 families in which the disease was common with a group lacking the illness.

The SWGR also has been used by STSI researchers who are studying the DNA of people with mysterious, or idiopathic, diseases that have defied more conventional diagnosis and treatment. The researchers are searching for rare genetic mutations that are related to the puzzling conditions.

"The SWGR will become more robust with time," said Ali Torkamani, director of genome informatics at STSI and an assistant professor of integrative, structural and computational biology at The Scripps Research Institute.

"As more DNA sequences from Wellderly Study participants are completed, their genomic data will be added to the Scripps Wellderly Genome Resource to strengthen the power of this innovative research tool," he said.


'/>"/>

Contact: Keith Darcé
darce.keith@scrippshealth.org
858-678-7121
Scripps Health
Source:Eurekalert  

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
4. Scripps Research Institute scientists develop antidote for cocaine overdose
5. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
6. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Plastic trash altering ocean habitats, Scripps study shows
10. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
11. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Wellderly Genome Resource now available to researchers
(Date:2/21/2017)... Ore. , Feb. 22, 2017  IBM (NYSE: ... (Avamere Health Services, Infinity Rehab, Signature Hospice, Home Health, ... will apply the power of IBM cognitive computing to ... centers. By analyzing data streaming from sensors in senior ... and environmental conditions, and obtain deeper learnings into the ...
(Date:2/16/2017)...  Genos, a community for personal genetic discovery ... Laboratory Accreditation from the College of American Pathologists ... that meet stringent requirements around quality, accuracy and ... "Genos is committed to maintaining the highest ... to be receiving CAP accreditation," said Jill ...
(Date:2/13/2017)... Feb. 13, 2017  RSA Conference -- RSA, a ... is designed to enhance fraud detection and investigation ... the RSA Fraud & Risk Intelligence Suite. The ... leverage additional insights from internal and external sources ... protect their customers from targeted cybercrime attacks. ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... LOS ANGELES , Feb. 23, 2017  Capricor Therapeutics, ... cardiac and other medical conditions, today announced that Linda Marbán, ... at two upcoming investor conferences: Cowen ... 2017 at 10:00 am ET Boston, MA ... 14, 2017 at 9:00 am PT (12:00 pm ET) ...
(Date:2/23/2017)... ... February 22, 2017 , ... Seventy-one members of ... Fellows of the Society this year, the Fellows Committee has announced. The honor ... optics, photonics, and imaging as well as their service to the Society and ...
(Date:2/22/2017)... ... 22, 2017 , ... Park Systems , a leader in Atomic Force ... SPIE attendees and Park customers on Feb. 27, 2017 from 12-2pm at ... Convention Center. The luncheon will feature a talk on Automated AFM for Small-Scale ...
(Date:2/22/2017)... , ... February 22, 2017 ... ... (TOPEC), the leading medical education provider of women’s health, primary care, ... the Accreditation Council for Continuing Medical Education (ACCME). ACCME’s Accreditation with Commendation ...
Breaking Biology Technology: