Navigation Links
Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
Date:1/12/2010

d as predicted and with such simplicity it seemed almost anticlimactic�macro-Palau'amine had only to be treated with acid and the quest was finally complete. The Baran group had synthetically produced Palau'amine for the first time ever.

Next Steps

Given the difficulty of the task, the synthesis would have been impressive at any length. But, with 25 steps currently involved, it would be difficult to make substantial quantities of Palau'imine for commercial purposes. So the Baran team has already devised a scheme that could shave as many as ten steps from the overall synthesis process and hopes to ultimately provide substantial quantities of the compound to other researchers and commercial partners that will pursue Palau'amine's pharmaceutical potential.

To Baran, the project has already led to substantial benefits regardless of whether the compound or some derivative of it ever shows commercial success. Pharmaceutical companies are already using the silver oxidation technique to produce other potential drugs, students have received an invaluable, and other lessons learned about synthesizing challenging compounds will ultimately be applied in numerous other quests.

"I see those types of advances as being the most useful things to come out of endeavors like this," says Baran.

Palau'amine tops a string of achievements for the Baran lab, most recently solving the two-decade old riddle of how to synthesize a compound called vinigrol that lowers blood pressure in rats. Results of this work were published in October 2009 in the Journal of the American Chemical Society, and are currently the journal's most downloaded paper.

While Palau'amine had achieved a special and rare prominence as an apex challenge, it's just one in a sea of other opportunities according to Baran, all with important potential benefits of their own.

"In my opinion there are a lot of treasures out there like Palau'amine," he sa
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
2. Scripps research team develops technique to determine ethnic origin of stem cell lines
3. Scripps Research scientists crack mystery of proteins dual function
4. Scripps Research team uncovers chemical basis for extra quality control in protein production
5. Scripps research scientists find new link between insulin and core body temperature
6. Scripps-led study shows ocean health plays vital role in coral reef recovery
7. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
8. Scripps studies offer new picture of Lake Tahoes earthquake potential
9. Scripps scientists help decode mysterious green glow of the sea
10. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
11. Scripps research scientists watch as individual alpha-synuclein proteins change shape
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... addition to the hippocampus, the marginal division of ... memory. What is the impact degree of substance ... and memory function? Yan Yu and his team, ... found, using immunofluorescence staining, that substance P receptor, ... and striatal marginal division of normal rats. Unilateral ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Industry Analysis Size Share Growth Trends and Forecast to ... http://photos.prnewswire.com/prnh/20130307/600769 The rising number ... for high level security in both private and public ... username and passwords, tokens etc. are vulnerable to attacks. ...
(Date:7/10/2014)... Albuquerque, and other major cities in New Mexico, nearly ... municipal wastewater rather than precious potable water supplies. Across ... of all golf courses receive treated effluent. Reusing the ... Additionally, golf courses and homeowners alike fertilize their lawns ... is nitrate. A New Mexico State University turfgrass expert ...
Breaking Biology News(10 mins):International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2'Tailored' water -- the latest in lawn care 2
... is available in French . Montreal -- ... consumers, thanks to Concordia University researchers who,ve developed a new ... products. "Even though Canada does not allow the use ... there were no methods or equipment to effectively measure residual ...
... With concerns about jobs in the headlines around the world, ... ( C&EN ) presents a 3-part cover story on the ... than 96% of all manufactured goods, with the chemical industry ... C&EN is the weekly newsmagazine of the American Chemical ...
... and BGI, the world,s largest genomics institute, today ... conduct large-scale human genome sequencing and bioinformatics analysis ... at Children,s Hospital. The partnership will focus on ... pediatric diseases using next-generation sequencing. The Center became ...
Cached Biology News:Children's Hospital of Philadelphia and BGI announce partnership and new Joint Genome Center 2
(Date:7/10/2014)... effect in bilayer graphene and shown that this exotic ... field. , The fractional quantum Hall effect, which ... exposed to large magnetic fields, is a striking example ... as a single system. However, while the basic theory ... this collective behavior remain not well understood, in part ...
(Date:7/10/2014)... spiders can sit upside down forever. Nanophysics makes sure of ... an article just published in Physical Review E . ... and spiders that seem to be able to sit still ... for many years. We will soon be able to buy ... gecko,s foot. But the fact is, sooner or later the ...
(Date:7/10/2014)... at the University of Illinois at Urbana-Champaign provides ... interplay of spin and heat at the nanoscale, ... devices for data storage and information processing. ... spin-angular momentum. In a typical charge current, electrons, ... current," explained David Cahill, a professor of materials ...
(Date:1/15/2014)... assembling a club sandwich at the nanoscale, National ... succeeded in crafting a uniform, multi-walled carbon-nanotube-based coating ... used in upholstered furniture and other soft furnishings. ... was reduced 35 percent compared with untreated foam. ...
Breaking Biology Technology:Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2
... SuperGen Inc.,(Nasdaq: SUPG ), a pharmaceutical company ... therapies for solid tumors and,hematological malignancies, today announced ... Officer is scheduled to present at the Thomas,Weisel ... the Four,Seasons Hotel in Boston. SuperGen,s presentation ...
... Aug. 29 Caliper Life,Sciences, Inc. (Nasdaq: ... the,Thomas Weisel Partners Healthcare Conference 2007 will be ... Kevin Hrusovsky, President and CEO,of Caliper, will be ... http://www.veracast.com/webcasts/twp/healthcare07/98209449.cfm . An archived,presentation will be available for ...
... Aug. 28 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS, Nasdaq: PXSL) ... of,Bronchitol for the treatment of people with bronchiectasis ... life and mucus clearance. Data from the ... quality of life after 12 weeks of treatment ...
Cached Biology Technology:Phase III Trial Finds Pharmaxis' Bronchitol Effective 2Phase III Trial Finds Pharmaxis' Bronchitol Effective 3
AC input: 50-60 Hz 115-120 V...
... This reagent is formulated specifically for Alkaline ... high levels of activity for both the ... at final dilution. This product has ... providing the customer a longer shelf life, ...
... valuable tool for removing SDS detergent from ... in biological samples imparts a negative charge ... enzymatic activity during digestion, and suppresses ion ... mass spectrometry analyses. We recommend that ...
Cells are grown in triple flasks, roller bottles, or NUNC Factory. Viability and growth curves are generated from a parallel representative culture....
Biology Products: