Navigation Links
Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
Date:1/12/2010

ever since he arrived at Scripps Research as a faculty member more than six years ago. During that time, the group developed techniques to synthesize several compounds related to Palau'amine, but the ultimate goal remained elusive. Numerous attempts, however, added important information and techniques that would ultimately prove critical.

The Quest Heats Up

Increasingly desperate and working with handheld molecular models, Baran and his team eventually hit on the idea of a molecule dubbed macro-Palau'amine that he felt his group could create. If so, he became convinced it could be transformed into Palau'amine. As work to create macro-Palau'amine heated up, graduate students, including the new paper�s first authors graduate student Ian Seiple and Research Associate Shun Su, Ph.D., would eventually set up a cot in the laboratory and begin to work around the clock.

"It was the Scripps Hilton for a long time," says Baran, "and when it was finally done we were all elated, as you might imagine."

The group's earlier trials produced intermediate compounds that took them part of the way to Palau'amine, but there was still much to do. One of the most significant later advances that allowed them to succeed was the invention of an oxidation reaction helped along by silver. The reaction could place an essential group of oxygen and hydrogen atoms known as a hydroxyl at a particular spot on an emerging molecule with seemingly laser-guided precision. The reagent that the Scripps Research team developed for this purpose, silver picolinate, has now been commercialized by Aldrich.

"The technique had no precedent, but we knew that if it could be invented it would dramatically simplify everything," says Baran�and it did.

This silver-mediated oxidation stabilized an intermediate molecule enough to allow five final steps to macro-Palau'amine. Once the team had that, the final transformation to Palau'amine proceede
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
2. Scripps research team develops technique to determine ethnic origin of stem cell lines
3. Scripps Research scientists crack mystery of proteins dual function
4. Scripps Research team uncovers chemical basis for extra quality control in protein production
5. Scripps research scientists find new link between insulin and core body temperature
6. Scripps-led study shows ocean health plays vital role in coral reef recovery
7. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
8. Scripps studies offer new picture of Lake Tahoes earthquake potential
9. Scripps scientists help decode mysterious green glow of the sea
10. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
11. Scripps research scientists watch as individual alpha-synuclein proteins change shape
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Feb. 25, 2015  ABC Financial Services (ABC), ... the Health and Fitness Industry, today announced enhancements ... MYiCLUBonline.  The latest upgrade includes advances to the ... cardless check-in via Identity One fingerprint biometrics. The ... through interactive displays at the International Health, Racquet ...
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are provided for ... is provided for these markets. Market data and analytics are ...
(Date:2/24/2015)... , Feb. 24, 2015 This report analyzes the ... the following Segments: Face Biometrics, and Voice Biometrics. The report provides ... Japan , Europe , ... Africa , and Latin America ... through 2020. Also, a seven-year historic analysis is provided for these ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
... new use as an adjuvant to cancer therapy, providing an ... study published in the Feb. 15 issue of Clinical Cancer ... Gallez, Ph.D., professor of pharmacy at the Université de Louvain ... A into two types of mouse tumors, the tumors' cellular ...
... H5N1 influenza samples in Southeast Asia shows not only ... are related but also that they belong to two ... for Disease Control and Prevention report their findings today ... "As the virus continues its geographic expansion, it is ...
... in Africa declared that a dramatic rise in tuberculosis (TB) ... TB case notifications have increased as much as four-fold over ... HIV. When individuals are infected with both HIV and TB, ... to active TB. , To combat the problem, the ...
Cached Biology News:Botox could help target resistant tumors for treatment 2Botox could help target resistant tumors for treatment 3Study outlines genetic differences between potential pandemic influenza strains 2
(Date:2/28/2015)... AZ (PRWEB) February 28, 2015 Increasing its ... World Films launches its first three episodes of The GMO ... Mile Project this month, as it continues its mission to ... launch, the project's first phase, to “uncover the truth about ... of media. , The GMO Truth Podcast is an expansion ...
(Date:2/27/2015)... 2015 Immunovaccine Inc. (“Immunovaccine” or the ... fraudulent press release disseminated this morning by PR Web, ... This press release states that Immunovaccine has entered into ... press release did not originate from Immunovaccine and there ... press release. Please note that all official statements ...
(Date:2/27/2015)... and SUMMERLAND, British Columbia ... (NYSE: XON ), a leader in synthetic ... to acquire  Okanagan Specialty Fruits (OSF), the pioneering ... , the world,s first non-browning apple. Through the acquisition, ... fruit that is more appetizing and convenient for consumers ...
(Date:2/27/2015)...  Pharmacyclics, Inc. (NASDAQ: PCYC ) ... newly developed Bruton,s tyrosine kinase (BTK) inhibitor for ... results of these preclinical evaluations have been communicated ... feedback received from the Agency is supportive of ... preclinical work is required to begin a Phase ...
Breaking Biology Technology:The Walk a Mile Project Launches “GMO Truth” Podcast 2Immunovaccine Disclaims Hoax Press Release 2Intrexon to Acquire Okanagan Specialty Fruits 2Intrexon to Acquire Okanagan Specialty Fruits 3Intrexon to Acquire Okanagan Specialty Fruits 4Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 2Pharmacyclics Provides Clinical Update on BTK Inhibitor for Autoimmune Diseases 3
... 4, 2011 InterMune, Inc. (NASDAQ: ITMN ) ... President of InterMune, will present at the Bank of America ... on May 11, 2011, at 1:00 p.m. PDT.   ... investors and other interested parties may log on to the ...
... a letter from Nicusa Capital urging BioClinica (Nasdaq: BIOC ... from incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy: ... Chairman of the Board BioClinica, Inc. 826 Newtown-Yardley Rd. Newtown, PA ... of BioClinica: As of May 4, 2011, Nicusa owns ...
... Inc. (Nasdaq: NXTM ), a leading manufacturer ... the first quarter of 2011 ended March  31, 2011, ... guidance range. (Logo: http://photos.prnewswire.com/prnh/20110503/MM94799LOGO) Net ... to a record $50.6 million compared with revenue of ...
Cached Biology Technology:This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 2This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 3This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 4This is a Letter From Nicusa Capital Urging BioClinica Shareholders to Vote AGAINST Proxy Proposal 2 and WITHHOLD Votes From Incumbent Directors Berg, Olukotun, Parker and Weinstein on 2011 Proxy 5NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 2NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 3NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 4NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 5NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 6NxStage® Reports Record Revenue for the First Quarter of Fiscal 2011 7
...
Homo sapiens MEP50 protein, mRNA...
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Can be used for the quantitative recovery of small amounts of nucleic acids within dilute solutions. 5mg/ml...
Biology Products: