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Scripps Research team uncovers chemical basis for extra 'quality control' in protein production
Date:12/9/2009

d the additional hydrogen bond with serine explain the chemical basis for frequent confusion of glycine and serine for alanine and the need for additional checks to make sure that alanine, not one of its look-alikes, is incorporated into a protein when called for.

"Now we can understand why nature takes so much effort to invent two editing checkpoints," said Guo. "That's what is necessary to have the correct sequence of amino acids in a protein. To me, it's amazing that a single chemical feature can determine the fate of almost every organism on earth. Organisms from bacteria to humans share the same biological solution that nature found to this critical chemical problem."


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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