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Scripps Research team provides groundbreaking new understanding of stem cells
Date:5/2/2010

uzdak, "although in retrospect it makes sense that stem cells (which can form almost any cell) have metabolites that are chemically flexible."

Confirming their observations, the researchers found that by chemically blocking the usual route to saturationoxidationthey were able to prevent stem cells' normal progress into mature heart and nerve cells. Conversely, when specific oxidized metabolites were introduced into the culture, stem cell differentiation was promoted.

Ding notes the study also provides a new perspective on fatty acids similar to those found in fish oil and other nutriceuticals.

"In the past, people focused on the fact that fatty acids were important to create cell membranes, the scaffolding of our cells," said Ding. "But in our study, we show that different fatty acids don't just play a role in constituting cell membranes, but also have functions in directing cell fate."


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Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

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