Navigation Links
Scripps Research team provides groundbreaking new understanding of stem cells
Date:5/2/2010

LA JOLLA, CA April 28, 2010 In findings that could one day lead to new therapies, researchers from The Scripps Research Institute have described some striking differences between the biochemistry of stem cells versus mature cells.

The study, led by Scripps Research Associate Professor Sheng Ding and Senior Director of the Scripps Research Center for Mass Spectrometry Gary Siuzdak, was published in an advance, online edition of the prestigious journal Nature Chemical Biology on May 2, 2010.

In the research, the team used a unique approach to better understand stem cells, which have the ability to change or "differentiate" into adult cell types (such as hair cells, skin cells, nerve cells). Understanding how stem cells mature opens the door for scientists and physicians to manipulate the process to meet the needs of patients, potentially treating such intractable conditions as Parkinson's disease and spinal injury.

"In the past, scientists trying to understand stem cell biology focused on genes and proteins," said Ding. "In our study, we looked at stem cell regulation in a different wayon the biochemical level, on a functional level. With metabolomics profiling, we were able to look at naturally occurring small molecules and how they control cell fate on a completely different level."

The new paper describes parts of the stem cell "metabolome" the complete set of substances ("metabolites") formed in metabolism, including all naturally occurring small molecules, biofluids, and tissues. The scientists then compared this profile to those of more mature cells, specifically of nerve cells and heart cells.

When the results were tallied, the scientists had found about 60 previously unidentified metabolites associated with the progression of stem cells to mature cells, as well as an unexpected pattern in the chemistry that mirrored the cells' increasing biological maturity.

Ripe for Discovery


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New Scripps Research and GNF study helps explain how we can sense temperatures
2. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
3. New nano-tool synthesized at Scripps Research Institute
4. Scripps Research scientists solve mystery of fragile stem cells
5. Scripps research team reveals how an old drug could have a new use for treating river blindness
6. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
7. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
8. Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
9. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
10. Scripps research team develops technique to determine ethnic origin of stem cell lines
11. Scripps Research scientists crack mystery of proteins dual function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... The Chinese University of Hong Kong, BGI and other ... to salt tolerance, with implication for improving this important ... online in Nature Communications provides an effective ... , Soybean is an important crop for the world. ... less genetic diversities than their wild counterparts. Among the ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
(Date:7/11/2014)... Ume University, Sweden, have explored two different ways ... sequence leading to the formation of oxygen molecules ... in the scientific journal Nature Communications . ... day synthetic catalysts for water oxidation, which are ... the direct storage of solar energy in fuels ...
Breaking Biology News(10 mins):BGI reports a novel gene for salt tolerance found in wild soybean 2Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2
... Lockheed Martin (NYSE: LMT ) has been ... of the Year" by Frost and Sullivan, recognizing the ... high levels of customer value. "Lockheed ... that play an important role our customer,s law enforcement ...
... Nitrogen is essential for plant growth. Despite the abundance ... must rely on a series of chemical reactions to ... forms. Plants have achieved this goal primarily by evolving ... nitrogen, plants, and the environment are the focus of ...
... Has a bone density scan placed you at risk ... bone-building medication? Not so fast! A University of Illinois study ... dietary calcium and vitamin D or taking calcium and vitamin ... be a last resort," said Karen Chapman-Novakofski, a U of ...
Cached Biology News:Lockheed Martin Named Biometrics "Company of the Year" by Frost and Sullivan 2Book looks at interrelationships among nitrogen, plants and the environment 2U of I study: Before you start bone-building meds, try dietary calcium and supplements 2U of I study: Before you start bone-building meds, try dietary calcium and supplements 3
(Date:7/10/2014)... 10, 2014  Franciscan St. Anthony Health-Crown ... for respiratory monitoring outside the operating room, ... in embracing state-of-the-art patient safety technology. ... breathing and can alert medical caregivers when ... amount of carbon dioxide the patient is ...
(Date:7/10/2014)... -- Research and Markets ( http://www.researchandmarkets.com/research/s3bqj2/photonic ) has ... Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... traces its roots in the latter half of ... went unexplored and unfulfilled for several decades owing ...
(Date:7/10/2014)... microscopic polymer light resonators that expand in the ... Photonics Laboratory have developed new optical sensors with ... sensors are ideal for detecting trace gas concentrations ... nature, and immunity to electromagnetic interference. , Although ... the MIT team conceived an extremely sensitive, compact ...
(Date:7/10/2014)... that power our laptops and electric vehicles could store ... with the help of a sponge-like silicon material. ... graphite traditionally used in one of the battery,s electrodes, ... storage capacity of graphite. A paper describing the material,s ... in Nature Communications . , "Silicon has long ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Swell new sensors 2Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3
Performance, mycoplasma, virus, and endotoxin tested...
... 10X BlueJuice Gel Loading ... easy loading and tracking ... agarose or native polyacrylamide ... features higher density sucrose ...
... is the most effective ... PCR products. TOPO TA ... TOPO vectors are supplied ... topoisomerase I. This enables ...
ready-to-use solution...
Biology Products: