Navigation Links
Scripps Research team finds a weak spot on deadly ebolavirus
Date:11/21/2011

LA JOLLA, CA November 20, 2011 Scientists from The Scripps Research Institute and the US Army's Medical Research Institute of Infectious Diseases have isolated and analyzed an antibody that neutralizes Sudan virus, a major species of ebolavirus and one of the most dangerous human pathogens.

"We suspect that we've found a key spot for neutralizing ebolaviruses," said Scripps Research Associate Professor Erica Ollmann Saphire, who led the study with US Army virologist John M. Dye.

The new findings, which were reported November 20, 2011, in an advance online edition of Nature Structural & Molecular Biology, show the antibody attaches to Sudan virus in a way that links two segments of its coat protein, reducing their freedom of movement and severely hindering the virus's ability to infect cells. The protein-linking strategy appears to be the same as that used by a previously discovered neutralizing antibody against the best-known ebolavirus species, Ebola-Zaire. The new study suggests that this may be the best way for vaccines and antibody-based therapies to stop ebolaviruses.

Deadly Outbreaks

Ebolaviruses first drew the attention of the medical world with simultaneous deadly outbreaks in 1976 in the nations of Sudan and Zaire (currently known as the Democratic Republic of the Congo). These two outbreaks were caused by the two major viruses: Ebola-Sudan and Ebola-Zaire, and early field studies showed that sera from patients that survived one virus could not help patients infected with the other. . Both viruses persist in animal hostsprobably batsand when they spread to humans, typically cause severe hemorrhagic fevers, killing up to 90 percent of people they sicken. Although not as contagious as influenza or measles, ebolaviruses can be transmitted in bodily fluids including exhaled airborne droplets, and scientists who study these viruses are generally required to use special "Biosafety Level 4" faciliti
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scripps research scientists develop brand new class of small molecules through innovative chemistry
2. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
3. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
4. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
5. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
6. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
7. 2 Scripps Research scientists win prestigious NIH Innovator Awards
8. Scripps Research team overcomes major obstacle for stem cell therapies and research
9. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
10. Scripps Research scientists establish new class of anti-diabetic compound
11. Scripps Research scientists produce first stem cells from endangered species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research team finds a weak spot on deadly ebolavirus
(Date:9/22/2014)... Ill. Antarctic fishes that manufacture their own ... Ocean also suffer an unfortunate side effect, researchers ... their bodies resist melting even when temperatures warm. ... Proceedings of the National Academy of Sciences ... an undesirable consequence of the evolution of antifreeze ...
(Date:9/22/2014)... burn in Khabarovsk Krai, a territory occupying the coastline of ... plumes of smoke mark active fires. The smoke, which appears ... Sea of Okhotsk. Taiga and tundra are found ... central depression, and deciduous forests are the natural vegetation in ... in the summer, the 2014 wildfire season appears to be ...
(Date:9/22/2014)... may be at greater risk for stress-related diseases ... according to a new study by Brandeis University. ... trigger biological responses similar to the effects of ... is an important part of our body,s healing ... life-threatening diseases. , In a recently published ...
Breaking Biology News(10 mins):Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 2Study: Antifreeze proteins in Antarctic fishes prevent freezingand melting 3Obesity and stress pack a double hit for health 2
... in preserving and promoting a healthy cardiovascular system than ... researchers at the Medical College of Wisconsin in Milwaukee. ... the scientific journal Hypertension, was led by David D. ... medicine and physiology, and senior associate dean of research ...
... the red jungle fowl, but new research from Uppsala University ... more complicated than that. The researchers mapped ... found to their surprise that this genetic heredity derives from ... study is being published today in the Web edition of ...
... Option for Voluntary Use of Biometrics, WASHINGTON, ... Legal Workforce today applauded the introduction of,legislation viewed ... system and to helping prevent unauthorized,employment, a key ... The New Employee Verification Act (NEVA) introduced today ...
Cached Biology News:New study shows low-fat diets more likely to reduce risk of heart disease than low-carb diets 2Darwin was wrong about the wild origin of the chicken 2HR Initiative Endorses Bill to Create an Effective, Mandatory Federal Employment Verification System 2HR Initiative Endorses Bill to Create an Effective, Mandatory Federal Employment Verification System 3
(Date:9/22/2014)... 2014 Follow us on ... biopolymers available in abundance in nature. These natural ... such as shells of crustaceans. The significant commercial ... to the high percentage of nitrogen present compared ... various industries owing to its exclusive properties such ...
(Date:9/22/2014)... Mass. and TORONTO ... Corporation ( www.generex.com ) (OTCBB:GNBT) today announced that ... Health Network (UHN) pursuant to which UHN,s Centre ... the Company,s buccal insulin refinement project.  The goal ... bioavailability of Generex Oral-lyn™, the Company,s proprietary buccal ...
(Date:9/22/2014)... The US markets on Friday, ... the Dow Jones Industrial Average finished at 17,279.74, up ... 0.30%. The S&P 500 finished the session 0.05% lower ... ten sectors finished on a positive note. The S&P ... 751.48, up 0.10%, with the index gaining 6.95% in ...
(Date:9/21/2014)... in Switzerland have succeeded in observing the "forbidden" ... first time. These extremely weak spectra offer perspectives ... may also contribute to the development of molecular ... in the scientific journal Nature Physics . ... matter and light, is probably the most important ...
Breaking Biology Technology:Emergence of New Application Areas to Drive the Global Chitin and Chitosan Market, According to New Report by Global Industry Analysts, Inc. 2Emergence of New Application Areas to Drive the Global Chitin and Chitosan Market, According to New Report by Global Industry Analysts, Inc. 3Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5Uncovering the forbidden side of molecules 2
... MATK ) today announced its financial results ... 2008. Revenues for the fourth,quarter were $90.4 million, up ... 2007. Net income was $10.5 million, or $0.31 per ... with $18.3 million, or $0.55 per,diluted share, in last ...
... Myngle,( http://www.myngle.com ), the global language platform, ... at the Europe Unlimited,s European Venture Summit,(EVS) ( ... EVS is a showcase for the most ... energy entrepreneurs from all over Europe to meet,and ...
... Health-focused social networks,blogs, wikis and community ... but can be their biggest opportunities. A ... discuss increasing,importance of reputation monitoring and management ... User Generated Content and Enhancing its Impact,on ...
Cached Biology Technology:Martek Announces Fourth Quarter and FY 2008 Financial Results 2Martek Announces Fourth Quarter and FY 2008 Financial Results 3Martek Announces Fourth Quarter and FY 2008 Financial Results 4Martek Announces Fourth Quarter and FY 2008 Financial Results 5Martek Announces Fourth Quarter and FY 2008 Financial Results 6Martek Announces Fourth Quarter and FY 2008 Financial Results 7Martek Announces Fourth Quarter and FY 2008 Financial Results 8Martek Announces Fourth Quarter and FY 2008 Financial Results 9Martek Announces Fourth Quarter and FY 2008 Financial Results 10Martek Announces Fourth Quarter and FY 2008 Financial Results 11Myngle Best ICT Company at the European Ventures Summit 2Exclusive Conference on Managing Your Online Brand: Shaping the Noise from the Blogosphere 2
Human M-CSF...
Human IL-19 MAb (Clone 152112)...
Mouse Activin RIB/ALK-4 MAb (Clone 207304)...
... (1995) This book contains up ... current issues relating to the aetiology and ... have been made recently which greatly improve ... molecular neuropathology through clinical and diagnostic aspects, ...
Biology Products: