Navigation Links
Scripps Research team creates new synthetic compound with HIV-fighting promise
Date:1/18/2011

LA JOLLA, CA January 18, 2011 Using chemical compounds found in a Japanese plant as a lead and the clever application of ultraviolet light, a Scripps Research Institute team has created a unique library of dozens of synthetic compounds to test for biomedical potential. Already, one of the compounds has shown great promise in inhibiting replication of HIV particles and fighting inflammation.

With the report of their work scheduled to appear in the online Early Edition of Proceedings of the National Academy of Sciences this week, the researchers now plan to optimize the compound's pharmaceutical potential so that it can be pursued as a drug candidate.

The plant Hypericum chinense, known in Japan as biyouyanagi, produces beautiful yellow flowers and, as it happens, potent chemical compounds known as biyouyanagins that have already shown promising anti-HIV and anti-tumor activity. That got the attention of K.C. Nicolaou, who holds the titles chair of the Department of Chemistry, Aline W. and L.S. Skaggs Professor of Chemical Biology, and Darlene Shiley Chair in Chemistry at Scripps Research. Nicolaou's interest was also piqued because the plant is from the same family that produces St. John's wort, and the biyouyanagins possess an intriguing molecular architecture.

"It was the perfect recipe for convincing a synthetic chemist to get into the game," said Nicolaou, who spearheaded the project in collaboration with a number of Scripps Research colleagues. "It seemed like there was so much to be discovered."

Best of Both Worlds

Within the biomedical field there are some researchers that argue natural products are the best route to new drug discovery. Others laud the potential of designing completely synthetic drugs. "I belong to both camps," says Nicolaou, because he prefers to start with natural products and then modify them in a variety of ways to create new synthetic products with improved potential. "The po
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research and Vanderbilt to launch joint institute
2. Scripps Research chemist devises new method to quantify protein changes
3. Scripps Research scientists identify key interaction in hepatitis C virus
4. Scripps Research scientist uncovers switch controlling protein production
5. Scripps Research scientists show prions mutate and adapt to host environment
6. Scripps scientists see the light in bizarre bioluminescent snail
7. Scripps Research scientists redefine the role of plasma cells in the immune system
8. Judy and J. John Goodman give $50,000 gift to Scripps Florida
9. New Scripps Florida scientist awarded pair of unconventional grants
10. Scripps Research scientists identify new mechanism regulating daily biological rhythms
11. Scripps Research team watches formation of cells protein factories for first time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... Mass , March 23, 2015 SoundView Technology ... of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was ... user feedback on their experience with the Wocket in multiple ... at CVS, Whole Foods and other retailers, making both debit ... Kris Tuttle also says, "If the company meets their ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... shrimp-like creature at the heart of the Antarctic food ... Southern Ocean with iron stimulating the growth of ... capacity for natural storage of carbon dioxide. ... Oceanography , an international team of researchers describe how ...
... viable future biofuel especially if harvested in summer. ... could provide an important alternative to terrestrial grown biofuels; ... a seasonal basis. Harvesting the kelp in July when ... sugar release for biofuel production. , "The storage carbohydrate ...
... by women of advanced maternal age (over 35 years) ... of meiosis a critical process of chromosome duplication ... of oocytes and sperm and leading to abnormalities ... failure, pregnancy loss or, more rarely, the birth of ...
Cached Biology News:Antarctic krill help to fertilize Southern Ocean with iron 2Biofuels from the sea 2Could ovarian stimulation cause an increase in oocyte chromosome abnormalities? 2Could ovarian stimulation cause an increase in oocyte chromosome abnormalities? 3
(Date:5/6/2015)... 2015   University of Maryland (UM) Ventures ... signing of an exclusive option by Biomecite Diagnostics for ... develop diagnostics to detect inflammatory bowel diseases (IBD), such ... Florian Fricke and James White ... University of Maryland School of Medicine,s Institute for Genome ...
(Date:5/6/2015)... 6, 2015  Oxis Biotech, Inc. (OXIS), a wholly ... announced today that Cassian Yee , M.D., Professor, ... at the University of Texas MD Anderson Cancer Center ... Professor, Department of Immunology, Division of Cancer Medicine, and ... Research at the University of Texas MD Anderson Cancer ...
(Date:5/6/2015)... 6, 2015 Whitefox ( ... today that it has signed an agreement with  ... PEIX ) for the delivery of an industrial scale membrane ... consumption of water, energy and emissions in ... This project is fully aligned with ...
(Date:5/6/2015)... , May 6, 2015 Dr ... of Massey University, will deliver a speech at the 2015 ... at the Shanghai New Expo Center.  ... will introduce to attendees the topic: ,Potato Starch: A ... and Smart Foods., Co-editor of a 528 ...
Breaking Biology Technology:Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 2Biomecite Diagnostics Signs Option Agreement with UM Baltimore to Develop Tools to Detect Inflammatory Bowel Diseases 3Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3Whitefox Signs Agreement With Pacific Ethanol Inc. 2Potato Starch: A Potential Source for the Creation of Next Generation Bulk-ingredients and Smart Foods 2
... Raju Kucherlapati , Professor of Genetics at Harvard ... making—will be addressing the Controlled Release Society on the subject of ... , , ... diagnosed with non small cell lung cancer before 2003, there were ...
... JERUSALEM , June 15, ... ), a developer of,alternative drug delivery systems, announced today ... presented by Chief Scientific Officer Dr. Miriam,Kidron , ... American,Diabetes Association, to be held in Orlando, Florida ...
... CARLSBAD, Calif. , June 15 Isis Pharmaceuticals, Inc. (Nasdaq: ... this series of conference calls focused on the drugs in Isis, development pipeline. ... will be held on Thursday, June 17, 2010 at 12:00 ... Isis, Web site. , , , ...
Cached Biology Technology:Personalized Treatments for Cancer Are Revolutionizing Patient Care 2Personalized Treatments for Cancer Are Revolutionizing Patient Care 3Oramed Pharmaceuticals was Chosen to Present Two Abstracts at the 70th Scientific Sessions of the American Diabetes Association in Orlando, FL, June 25-29, 2010 2Oramed Pharmaceuticals was Chosen to Present Two Abstracts at the 70th Scientific Sessions of the American Diabetes Association in Orlando, FL, June 25-29, 2010 3Isis Pharmaceuticals to Discuss Its Neurodegenerative Franchise in a Conference Call on Thursday, June 17 2Isis Pharmaceuticals to Discuss Its Neurodegenerative Franchise in a Conference Call on Thursday, June 17 3
Request Info...
Kit contains: Bio-Rad Amplification Reagent, 2x Amplification Diluent, Streptavidin-HRP, Blocking Reagent, and Phosphate Buffered Saline....
... gun unit, 5 O-rings, 5 barrel liners, 5 ... battery The Helios gene gun is a ... gene transfer into a range of targets in ... pulse to sweep DNA- or RNA-coated gold microcarriers ...
Mouse polyclonal antibody to PRDM2 - PR domain containing 2, with ZNF domain...
Biology Products: