Navigation Links
Scripps Research team creates new synthetic compound with HIV-fighting promise
Date:1/18/2011

LA JOLLA, CA January 18, 2011 Using chemical compounds found in a Japanese plant as a lead and the clever application of ultraviolet light, a Scripps Research Institute team has created a unique library of dozens of synthetic compounds to test for biomedical potential. Already, one of the compounds has shown great promise in inhibiting replication of HIV particles and fighting inflammation.

With the report of their work scheduled to appear in the online Early Edition of Proceedings of the National Academy of Sciences this week, the researchers now plan to optimize the compound's pharmaceutical potential so that it can be pursued as a drug candidate.

The plant Hypericum chinense, known in Japan as biyouyanagi, produces beautiful yellow flowers and, as it happens, potent chemical compounds known as biyouyanagins that have already shown promising anti-HIV and anti-tumor activity. That got the attention of K.C. Nicolaou, who holds the titles chair of the Department of Chemistry, Aline W. and L.S. Skaggs Professor of Chemical Biology, and Darlene Shiley Chair in Chemistry at Scripps Research. Nicolaou's interest was also piqued because the plant is from the same family that produces St. John's wort, and the biyouyanagins possess an intriguing molecular architecture.

"It was the perfect recipe for convincing a synthetic chemist to get into the game," said Nicolaou, who spearheaded the project in collaboration with a number of Scripps Research colleagues. "It seemed like there was so much to be discovered."

Best of Both Worlds

Within the biomedical field there are some researchers that argue natural products are the best route to new drug discovery. Others laud the potential of designing completely synthetic drugs. "I belong to both camps," says Nicolaou, because he prefers to start with natural products and then modify them in a variety of ways to create new synthetic products with improved potential. "The po
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research and Vanderbilt to launch joint institute
2. Scripps Research chemist devises new method to quantify protein changes
3. Scripps Research scientists identify key interaction in hepatitis C virus
4. Scripps Research scientist uncovers switch controlling protein production
5. Scripps Research scientists show prions mutate and adapt to host environment
6. Scripps scientists see the light in bizarre bioluminescent snail
7. Scripps Research scientists redefine the role of plasma cells in the immune system
8. Judy and J. John Goodman give $50,000 gift to Scripps Florida
9. New Scripps Florida scientist awarded pair of unconventional grants
10. Scripps Research scientists identify new mechanism regulating daily biological rhythms
11. Scripps Research team watches formation of cells protein factories for first time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... found to be a key gene responsible for hearing in ... cells of the inner ear that contracts and expands rapidly ... phonograph horn, amplify sound waves to make hearing more sensitivity. ... advanced online edition of Molecular Biology and Evolution , ... independently evolved to play a critical role in the ultrasonic ...
(Date:7/31/2014)... Fla. --- By tracing nearly 3,000 genes to ... University of Florida scientists have created an extensive ... use large-scale, next-generation DNA sequencing. , Among ... closely related to small moths than to large ... butterflies evolved. The study also found that some ...
(Date:7/31/2014)... DARIEN, IL Researchers who studied 100 twin pairs have ... function normally on less than six hours of sleep per ... resistance to the effects of sleep deprivation. , Results show ... BHLHE41 gene had an average nightly sleep duration of ... than the non-carrier twin, who slept for about six hours ...
Breaking Biology News(10 mins):UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Study of twins discovers gene mutation linked to short sleep duration 2
... 2011)Regular exercise has proven benefits in preventing and ... tough to meet the American Diabetes Association guidelines of ... A new study, conducted by researchers at McMaster University, ... a small proof-of-principle study in eight type 2 diabetes ...
... How to manage waste has become one of the ... of electrical and electronic equipment that is designed, manufactured and ... and at times highly toxic. Up to 1,200 companies working ... to 10% of their recycling costs thanks to this new ...
... plant growth enhancers are becoming increasingly sought-after. Many ... with limited research capabilities, have not been tested ... effectiveness been documented by scientific data. Researchers from ... effect of Tea Seed Powder (TSP), a saponin-rich ...
Cached Biology News:Exercising harder -- and shorter -- can help Type 2 diabetes 2Exercising harder -- and shorter -- can help Type 2 diabetes 31,200 recycling sector companies will save up to 10 percent thanks to a new system developed by Tecnalia 2Plant growth affected by tea seed powder 2
(Date:7/31/2014)... New York , July 31, 2014 ... by Transparency Market Research "Quantum Dots Market - Global ... - 2023," the market was valued at USD 88.5 ... 8,246.8 million by 2023, growing at a CAGR of ... full Quantum Dots Market Report at  http://www.transparencymarketresearch.com/quantum-dots.html ...
(Date:7/31/2014)... July 31, 2014 Graphite Metallizing Corporation ... temperature oven carts. These bearings are uniquely suited to ... ball bearings because of the high temperatures . ... help from the design engineers at Graphite Metallizing to ... process. During their manufacturing operation, pans containing blocks of ...
(Date:7/31/2014)... , July 31, 2014 According ... Research "Electrodes for Medical Devices Market (Diagnostic Electrodes - ... Electrodes - TENS, Pacemakers, Defibrillators, Electrosurgical and Other Electrodes) ... Forecast, 2013 - 2019," the global electrodes market for ... 2012 and is estimated to reach a market worth ...
(Date:7/31/2014)... Francisco, California (PRWEB) July 31, 2014 ... systems that inform therapeutic decision-making in oncology, today announced ... August 14, 2014 to discuss the Company's financial results ... provide an update about the business in the current ... audio call beginning on Thursday, August 14, 2014, at ...
Breaking Biology Technology:Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 2Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 3Global Quantum Dots Market is Expected to Reach USD 8,246.8 Million in 2023: Transparency Market Research 4Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 2Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 3Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 4Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 5Electrodes for Medical Devices Market Expected to Reach USD 1.45 Billion Globally in 2019: Transparency Market Research 6CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... fields and tiny iron-bearing particles to drive healthy cells ... in animals, may lead to a new method of ... organs in people. , The study team, led by ... of Pediatric Cardiology at The Childrens Hospital of Philadelphia, ...
... ALTO, Calif., Jan. 7 Telik, Inc. (Nasdaq: ... overview at the,26th Annual JPMorgan Healthcare Conference in San ... Pacific time (10:30 a.m. Eastern,time). A live and archived ... website, http://www.telik.com ., Telik, Inc. of Palo ...
... Potential Blockbuster Product for High Risk Cardiovascular ... ... Calif., Jan. 7 ,Genzyme Corp. (Nasdaq: GENZ ) and Isis ... a major strategic alliance in which,Genzyme will develop and commercialize mipomersen, ...
Cached Biology Technology:Researchers use magnetism to target cells to animal arteries 2Researchers use magnetism to target cells to animal arteries 3Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 2Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 3Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 4Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 5Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 6Genzyme and Isis Announce Strategic Alliance Including Exclusive Worldwide License of Mipomersen 7
A univariate (peak height or area) quantitative multi-component analysis package....
... The micro 1 is a dramatic breakthrough ... from 1mL with 10nL resolution, the micro 1 ... benchtop dispenser. And, the micro 1 never needs ... , Touch Screen programming on an LCD Display ...
... microscopes offer all of the features of ... Equipped with Koehler illumination, a centerable condenser ... B3 is the workhorse of Motic's range ... the need for re-focusing following a change ...
... Dye Primer Manual Cycle Sequencing Kit is ... primers and high-resolution fluorescence scanners. Sequencing reactions ... slab gel electrophoresis and scanning of the ... The kit components have been optimized ...
Biology Products: