Navigation Links
Scripps Research study sheds light on RNA 'on/off switches'
Date:2/13/2011

LA JOLLA, CA Embargoed by the journal Nature Structural and Molecular Biology until February 13, 2011, 1 PM Eastern time Scientists from The Scripps Research Institute have shed new light on a molecular switch that turns genes on or off in response to a cell's energy needs.

The studypublished February 13, 2011 in an Advance Online Publication of the journal Nature Structural and Molecular Biologyshows these recently discovered RNA "riboswitches" are capable of more complex functions than originally thought. In addition, because riboswitches so far have been found primarily in bacteria, the study may have implications for designing new antibiotics against harmful bacteria.

"The study provides new insights into how a single RNA molecule can integrate both positive and negative signals from a cell," said senior author Martha Fedor, an associate professor and member of the Skaggs Institute for Chemical Biology at Scripps Research. "It extends the known capabilities of riboswitches."

Riboswitches respond to the concentrations of molecules produced by a cell's metabolismthe process of creating or using energyto regulate genes' activities. The new study shows that a particular riboswitch does not respond to just a single metabolite, as had been assumed, but rather to many such compounds.

Switching Genes On and Off

Each gene serves as a recipe for building a protein molecule. When a particular protein is needed by the cell, the corresponding gene, made of DNA, is turned "on," or transcribed into a messenger RNA, which then carries the "protein recipe" to the protein-making machinery of the cell.

For many years scientists thought proteins, unlike DNA and RNA, were the only molecules in a cell capable of accomplishing sophisticated tasks, such as regulating the activities of genes or carrying out chemical reactions. But in the past couple of decades, researchers have discovered that certain ty
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps Research scientist discovers natural molecule indirectly prevents stable clot formation
2. Scripps Research scientists convert skin cells to beating heart cells
3. Scripps Research scientists reveal key mechanism governing nicotine addiction
4. Scripps Research team creates new synthetic compound with HIV-fighting promise
5. Scripps Research and Vanderbilt to launch joint institute
6. Scripps Research chemist devises new method to quantify protein changes
7. Scripps Research scientists identify key interaction in hepatitis C virus
8. Scripps Research scientist uncovers switch controlling protein production
9. Scripps Research scientists show prions mutate and adapt to host environment
10. Scripps scientists see the light in bizarre bioluminescent snail
11. Scripps Research scientists redefine the role of plasma cells in the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , 31 de julio de 2015 La ... ) se celebrará por medio de BGI del 22 al 25 ... . Este año, la conferencia celebra su ... se ha convertido en una de las reuniones anuales más ... una de las reuniones más dinámicas, entusiastas y mejores a ...
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 /PRNewswire/ ... and services for gene function analysis and biomarker ... Guide RNA (sgRNA) Knockout Library targeting all human ... specifically and permanently "knock out" a gene,s function. ... provides a high throughput screening tool so that ...
(Date:7/23/2015)... , July 23, 2015 Research ... addition of the "Global Outlook of the ... offering. The global biometrics market ... public and commercial applications owing to the uptake ... witness a transformation that enhances the growth of ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... A&M University and University of North Carolina School of ... of diet complexity and estrogen hormone receptors on intestinal ... promoting the growth of certain beneficial intestinal microorganisms can ... determine the effect,of certain factors on intestinal microbiota. ...
... are already used in the displays of smart phones or ... high contrast, but come with a serious drawback: typically, only ... device is actually converted into light. This ratio can be ... or iridium to the active material, but these elements are ...
... An international team of researchers, co-led by scientists at ... produced the first multi-disciplinary evidence for management of cattle ... domestication took place in the Near East, over 10,000 ... achievement in human history. Until now, researchers believed that ...
Cached Biology News:Gut reaction 2Novel LEDs pave the way to cheaper displays 2Researchers uncover origins of cattle farming in China 2
(Date:8/4/2015)... -- Trigemina, Inc., a biopharmaceutical company focused on the ... products, announced today that the company has appointed Shashidhar ... officer. Dr. Kori brings over 30 years of clinical ... focused in the neuroscience and headache space. ... clinical team given his vast experience managing clinical development ...
(Date:8/4/2015)... ... August 04, 2015 , ... On August 4, 2015, the White House ... entrepreneurs from across the United States to talk about their experiences with innovation and ... chosen to be among the attendees. , One of the day’s aims is to ...
(Date:8/3/2015)... At the 11th hour, London,s ... of Jude Liversage,s campaign so the seven-year-old ...      (Photo: http://photos.prnewswire.com/prnh/20150803/254228 ) ... The Selective Dorsal Rhizotomy (SDR) procedure reduced the spasticity ... wish to kick a ball around like his schoolmates. ...
(Date:8/3/2015)... Medical, Inc. (Nasdaq: AEMD ), the pioneer in ... announced that it will host its First Quarter Fiscal ... 13, 2015 at 4:30 p.m. Eastern Time. ... fiscal 2016 first quarter results.  A recorded version of ... the call at the Investor Relations portion of the ...
Breaking Biology Technology:Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 2Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 3White House Invites uBiome CEO Jessica Richman to First-Ever Startup Demo Day 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 2Cerebral Palsy Operation by The Portland Hospital Allows a Boy to Stand Properly for the First Time 3Aethlon Medical To Host First Quarter Fiscal 2016 Investor Call on August 13, 2015 2
... 12 Eli Lilly and Company (NYSE: LLY ... the 45th Annual Meeting of the American Society of Clinical ... 2, 2009, with the majority of the presentations continuing to ... will present the latest research findings on ALIMTA(R) (pemetrexed for ...
... , - For the ... use CPMRC,s Interdisciplinary Clinical Content Through TSG,s Integrated,Portal Solutions ... and The Shams Group (TSG) have partnered to,provide small- ... integrates with their current health,information systems. , ...
... MSEDMONTON, May 11 /PRNewswire-FirstCall/ - BioMS Medical Corp. (TSX: ... sclerosis (MS), today announced financial and operational results for ... remain on track to obtain the results from MAESTRO-01, ... in patients with secondary progressive multiple sclerosis, in the ...
Cached Biology Technology:Lilly Set to Unveil More Than 50 Studies at ASCO 2009 2Lilly Set to Unveil More Than 50 Studies at ASCO 2009 3Lilly Set to Unveil More Than 50 Studies at ASCO 2009 4Lilly Set to Unveil More Than 50 Studies at ASCO 2009 5Lilly Set to Unveil More Than 50 Studies at ASCO 2009 6CPM Resource Center and The Shams Group Partner To Help Hospitals Integrate Evidence-Based Clinical Content Into Information Systems 2CPM Resource Center and The Shams Group Partner To Help Hospitals Integrate Evidence-Based Clinical Content Into Information Systems 3CPM Resource Center and The Shams Group Partner To Help Hospitals Integrate Evidence-Based Clinical Content Into Information Systems 4BioMS Medical Announces First quarter 2009 results 2BioMS Medical Announces First quarter 2009 results 3BioMS Medical Announces First quarter 2009 results 4BioMS Medical Announces First quarter 2009 results 5BioMS Medical Announces First quarter 2009 results 6BioMS Medical Announces First quarter 2009 results 7BioMS Medical Announces First quarter 2009 results 8BioMS Medical Announces First quarter 2009 results 9
... Spring offers a large collection of ... fetal tissuea, cell lines, and mouse ... in pHD9 vector. The size of ... be from 200bp to 1000bp by ...
... and convenience from the former kit #17295. However, ... problem but also produced some advantages as follows. ... HRP conjugated antibody from lyophilized product to liquid ... of the conjugate has improved so that the ...
Mouse monoclonal [BC-4] to Aggrecan xxPEN ( Abpromise for all tested applications). entrezGeneID: 176 SwissProtID: P16112...
... low melting point agarose where separation is ... for separation of nucleic acids less than ... Micro ABgarose is also suited to capillary ... techniques. At a 3% concentration, Micro ABgarose ...
Biology Products: