Navigation Links
Scripps Research study overturns decade-old findings in neurobiology
Date:5/12/2010

rain region use GABA to fine-tune signaling throughout the nervous system. Previous studies by the Scripps Research scientists indicated that GABA plays a critical role in alcohol dependence and other addictions.

"We knew ethanol in these neurons increase GABA transmission, and that cannabinoids decrease GABA transmission," said Roberto. "So the question was what happens if we activate the cannabinoid system and we put ethanol on it."

When the scientists first applied the CB1 agonist on cells from the central amygdala, it decreased GABA transmission; when the scientists proceeded to put ethanol on top, the effect of ethanol was abolished. When the team reversed the order of application, GABA transmission first went up with the application of ethanol, then down with the application of the CB1 agonist.

"Alcohol and CB1 agonists have opposing effects on GABA," summarized Schweitzer. "Our feeling is that since the CB1 system is so widely expressed, there's a big role there in dampening the effect of alcohol."

While the team's research points to the endocannibinoid system as a potential target in the development of drugs to treat alcoholism, Schweitzer notes there are still many questions to be answered: Do CB1 agonists work the same way in brains that have become addicted to alcohol? What is the mechanism for this action? Can the effects of CB1 on alcohol metabolism be separated from its many other effects on mood, appetite, and memory?

Schweitzer also cautions against equating CB1 agonists and cannabis in interpreting the study's results. "This study does not have to do with marijuana, but the endocannabinoid system," he said. "On this level of analysis, the two don't have much in common."


'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists shed light on potential treatment for Gauchers disease
2. Scripps Research team provides groundbreaking new understanding of stem cells
3. New Scripps Research and GNF study helps explain how we can sense temperatures
4. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
5. New nano-tool synthesized at Scripps Research Institute
6. Scripps Research scientists solve mystery of fragile stem cells
7. Scripps research team reveals how an old drug could have a new use for treating river blindness
8. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
9. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
10. Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
11. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
... but many dinosaurs apparently had genomes no larger than that ... bone cell and genome size among living species and then ... 31 species of extinct dinosaurs and birds, whose bone cells ... researchers, at Harvard University and the University of Reading, were ...
... such as Unreal Tournament, can actually improve your vision. ... people who played action video games for a few hours ... about 20 percent in their ability to identify letters presented ... regular ophthalmology clinics. , In essence, playing video game ...
... Pennsylvania School of Medicine & School of Engineering and ... drugs to tumors. By using a cylindrical-shaped carrier they ... to an animal model of lung cancer ten times ... have implications for drug delivery as well as for ...
Cached Biology News:Despite their heft, many dinosaurs had surprisingly tiny genomes 2Action video games sharpen vision 20 percent 2Penn researchers show how nanocylinders deliver medicine better than nanospheres 2
(Date:11/26/2014)... -- Theravalues Corporation annuncia con orgoglio il lancio di ... Hi Europe 2014 (dal 2 al 4 dicembre, ... curcumina con la maggiore biodisponibilità di sempre, con una ... dalle norme europee. La curcumina è un ... Curcuma longa ) che è stata associata con attività ...
(Date:11/24/2014)... , Nov. 24, 2014  Last week, Representatives ... Butterfield (D-NC) took a bold bipartisan step ... introducing the OPEN Act. Original co-sponsors of the ... The Act will incentivize drug makers and innovators ... diseases and pediatric cancers, which opens the door ...
(Date:11/24/2014)... November 23, 2014 One of the most ... optics and photonics is now available to high school and ... cost. SPIE, the international society for optics and photonics ... complete SPIE Digital Library available to high schools ... “Light-based technologies are integral to all areas of life in ...
(Date:11/24/2014)... Nov. 24, 2014  Spherix Incorporated (Nasdaq: ... to the fostering and monetization of intellectual property, ... Telecommunications Ltd.,  Case No. 3:13-cv-03494-M and  Spherix v. ... both in the United States District Court for ... . On November 21, 2014 ...
Breaking Biology Technology:La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2Markman Hearing Held as Scheduled in VTech and Uniden Cases 2
... PolyOne Corporation,(NYSE: POL ), a premier ... today that it has entered into an exclusive,license ... owned by Battelle., The global market for ... all production consumed in vinyl-based formulations.,Specialty plasticizers currently ...
... 107% over Second Quarter 2007, EMERYVILLE, Calif., Aug. ... reported its financial results,for the three and six months ... million, or $0.08 per diluted share, for the second ... million, or $0.22 per diluted share, in the,same period ...
... /PRNewswire-FirstCall/ - Atrium Innovations Inc.,(TSX: ATB), a recognized ... endorsed products for the health and,nutrition industries, today ... Pierre Fitzgibbon, will present a company overview,at the ... on,Tuesday, August 12, 2008 at 11 am (eastern ...
Cached Biology Technology:PolyOne Corporation Announces an Exclusive License Agreement with Battelle for Bio-Plasticizer Technology 2Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 2Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 3Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 4Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 5Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 6Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 7Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 8Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 9Onyx Pharmaceuticals Reports Second Quarter and Six-Month 2008 Financial Results 10
Request Info...
... kit contains the basic components required for ... natural and recombinant canine Monocyte Chemotactic Protein ... serum.1 Each kit contains sufficient materials to ... provided that the following conditions are met:2 ...
Rat monoclonal [HEK/1/85a] to CCR5 ( Abpromise for all tested applications). entrezGeneID: 1234 SwissProtID: P51681...
... MaV203 Competent Yeast Cells are designed ... (Figure 1). S. cerevisiae strain MaV203 contains ... genes for use with GAL4-based two-hybrid systems. ... mutations for selection of ProQuest bait and ...
Biology Products: