Navigation Links
Scripps Research study overturns decade-old findings in neurobiology
Date:5/12/2010

s Research Associate Professor Loren "Larry" Parsonshad suggested that the endocannabinoid system (and by implication its receptors) were indeed active in this brain region.

The Scripps Research team decided to take a fresh look at the whole question, and set out to conduct a new physiological study specifically looking for signs of the missing CB1 receptors in the central amygdala.

"There wasn't much physiology done before this," said Roberto. "There were a lot of behavioral studies, but very few on physiology and, aside from the 2001 study, none on the physiology in the central amygdalathis brain region that is so important for drugs of abuse."

Back on Track

Using electrophysiological techniques in brain slices to test the response of brain cells from the rat central amygdala, the scientists indeed found compelling evidence that CB1 receptors were active there.

The cells responded to a substance (agonist) mimicking the action of endocannabinoids in the brain. Up to a point, the more of the agonist the scientists applied, the bigger the effect. An inhibitor (antagonist) reversed this response.

"We saw a big and consistent physiological effect," said Roberto. "It was beautiful. The receptor had to be there or otherwise it wouldn't have worked."

With this major milestone achieved, the researchers extended their investigation to their primary area of interestthe brain's response to alcohol. Alcohol abuse can lead to devastating consequences for individuals and families. It is also associated with direct and indirect public health costs estimated to be in the hundreds of billions of dollars yearly in the United States alone.

To learn more about the effect of alcohol on the biology of the brain, the scientists focused on the transmission of one particular neurotransmitter called gamma amino butyric acid (GABA). GABA is the main inhibitory neurotransmitter in the brain, and neurons in every b
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists shed light on potential treatment for Gauchers disease
2. Scripps Research team provides groundbreaking new understanding of stem cells
3. New Scripps Research and GNF study helps explain how we can sense temperatures
4. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
5. New nano-tool synthesized at Scripps Research Institute
6. Scripps Research scientists solve mystery of fragile stem cells
7. Scripps research team reveals how an old drug could have a new use for treating river blindness
8. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
9. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
10. Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
11. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... be cheerful, happy-go-lucky characters, so you might expect that ... , In fact some dogs are distinctly more pessimistic ... , "This research is exciting because it measures ... non-invasively. It offers researchers and dog owners an insight ... said Dr Melissa Starling, from the Faculty of Veterinary ...
(Date:9/18/2014)... are too stressed they are often grouchy, grumpy, nasty, ... (BMI) at EPFL have just highlighted a fundamental synaptic ... the loss of social skills and cognitive impairment. When ... molecule in the brain. This was revealed by a ... Carmen Sandi,s team went to look for answers in ...
(Date:9/17/2014)... and affordable health care to reproductive technologies, the ... the ability of people to identify key issues, ... respectfully, and find the most defensible ways forward. ... support these societal conversations?, The Hastings Center and ... Issues have teamed up to publish a series ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... America (ESA) is proud to announce the winners ... travel grants, which will help entomology students attend ... this November are funded by USDA-NIFA,s Agriculture ... and Nematodes. The grants were created to provide ...
... predicted that tree species will respond to global warming ... a new study of 65 different species in 31 ... Nearly 80 percent of the species aren,t yet ... staying in place -- but speeding up their life ...
... Children,s Hospital Medical Center has developed an antibody that ... hospitalized patients who receive central lines. Margaret Hostetter, ... her team developed the antibody, which prevents Candida ... formation of biofilm in a rat model of catheter-associated ...
Cached Biology News:Entomological Society of America names winners of 2013 student travel grants 2Entomological Society of America names winners of 2013 student travel grants 3Entomological Society of America names winners of 2013 student travel grants 4Entomological Society of America names winners of 2013 student travel grants 5Entomological Society of America names winners of 2013 student travel grants 6Entomological Society of America names winners of 2013 student travel grants 7Entomological Society of America names winners of 2013 student travel grants 8Climate change may speed up forests' life cycles 2
(Date:9/19/2014)...  InterMune, Inc. (Nasdaq: ITMN ) today ... to settle the litigation in the Delaware Court of ... dated as of August 22, 2014, among Roche Holdings, ... term of the Memorandum of Understanding, the Company agreed ... attached exhibit reflecting the amendment to the Company,s Schedule ...
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
(Date:9/19/2014)... Barnhardt Manufacturing Company has earned the ... Cotton . The USDA Certified Biobased Product Label verifies ... or exceeds levels set by USDA. Biobased products are ... significant part of agricultural, forestry, or marine ingredients. ... be immediately identified as a USDA certified BioPreferred ...
(Date:9/18/2014)... Bipartisan passage this week by the ... stimulate development and commercialization of new technologies and promote ... of SPIE, the international society for optics and ... Innovation (RAMI) Act, now moves to the full Senate ... are optimistic that it will win passage there as ...
Breaking Biology Technology:InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3
...  inVentiv Health, Inc., offering best-in-class clinical, commercial and ... it has completed the acquisition of Kforce Clinical ... solutions to pharmaceutical, biotech and medical device companies, ... The transaction closed on March 30, 2012.  ...
... 3, 2012 Health Diagnostic Laboratory, Inc. (HDL, Inc.), ... of Scott Blackwell. Recently named Vice President of Corporate ... values of an advanced laboratory that is growing on ... http://photos.prnewswire.com/prnh/20120403/PH81634 )  "Scott comes to our ...
... N.J., April 3, 2012 Hamamatsu Corporation announces ... distributed through third-party dealers, will now be available ... the company is responsible for the sales, marketing, ... product line for new customers throughout North America. ...
Cached Biology Technology:inVentiv Health Completes Acquisition of Kforce Clinical Research 2inVentiv Health Completes Acquisition of Kforce Clinical Research 3inVentiv Health Completes Acquisition of Kforce Clinical Research 4Health Diagnostic Laboratory Names Scott Blackwell Vice President of Corporate Culture 2Hamamatsu Corporation Announces Exclusive Distribution of Its NanoZoomer Whole-Slide Scanners 2
... binding specificity and signaling of the members ... be modified by alternative splicing--which has important ... you can perform a classical expression profiling ... different alternatively spliced forms of the gene ...
Mouse monoclonal antibody raised against a partial recombinant ST3GAL2. NCBI Entrez Gene ID = ST3GAL2...
... Extraction Kit is manufactured for DNA purification ... byexposure to UV light. The Purification of ... used for DNA-cloning work. The conventional method ... exposure of UV light damages DNA and ...
CleanBox DNA workstation with two 254nm UV lambs & 12-hr timer, 90cm (36-inch)width, single door, 115V (w/crating)...
Biology Products: