Navigation Links
Scripps Research study overturns decade-old findings in neurobiology
Date:5/12/2010

LA JOLLA, CA May 12, 2010 In findings that should finally put to rest a decade of controversy in the field of neurobiology, a team at The Scripps Research Institute has found decisive evidence that a specific neurotransmitter systemthe endocannabinoid systemis active in a brain region known to play a key role in the processing of memory, emotional reactions, and addiction formation. The new study also shows that this system can dampen the effects of alcohol, suggesting an avenue for the development of drugs to combat alcohol addiction.

The research was published in the journal Neuropsychopharmacology on May 12.

"This study will change a lot in the field," said Scripps Research Associate Professor Marisa Roberto, who was first author of the paper. "I'm confident it will have a big impact."

"This is very new," said Paul Schweitzer, associate professor of the neurobiology of addiction at Scripps Research and corresponding author of the paper. "It is the first time a study has shown a direct cellular interaction between endocannabinoids and alcohol in the brain."

The Missing Link?

The new research overturns the conclusions of a paper published by a European group in the Journal of Neuroscience in 2001. This paper claimed that endocannabinoid receptors, in particular the most common type called CB1, did not exist in the brain region called the central amygdala.

"Yet CB1 receptors are very abundant," said Schweitzer. "They are almost everywhere in the brain and there are lots of them. The endocannabinoid system acts on appetite, mood, memoryand addiction. Addiction is why we started to study it in the central amygdala."

The Scripps Research scientists began to suspect that the 2001 study, whose conclusions had been widely accepted in the field, might have missed the CB1 receptors in the brain's central amygdala. Indirect evidence from a number of subsequent studiesincluding one by Scripp
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research scientists shed light on potential treatment for Gauchers disease
2. Scripps Research team provides groundbreaking new understanding of stem cells
3. New Scripps Research and GNF study helps explain how we can sense temperatures
4. Scripps Research scientists reveal how genetic mutations may cause type 1 diabetes
5. New nano-tool synthesized at Scripps Research Institute
6. Scripps Research scientists solve mystery of fragile stem cells
7. Scripps research team reveals how an old drug could have a new use for treating river blindness
8. Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
9. Scripps Research scientists create new way to screen libraries of 10 million or more compounds
10. Scripps Research team wins global race to achieve landmark synthesis of perplexing natural product
11. Scripps Florida scientists show lifeless prions capable of evolutionary change and adaptation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... news release is available in German . ... to pay the protection money demanded of him, he can ... seldom required, however, as fear of the consequences is enough ... observed in parasitic birds, which lay their eggs in other ... out, the brood parasites take their revenge by destroying the ...
(Date:4/17/2014)... deforestation and fragmentation of forests in the Amazon ... forests, contributing to rapid and widespread forest loss ... researchers., The findings show that forests in the ... droughts coupled with forest fires lead to large-scale ... Jennifer Balch, assistant professor of geography, Penn State. ...
(Date:4/17/2014)... many serious conditions such as heart disease, epilepsy and ... therapies. Unfortunately, there is still much scientists do not ... and unexpected insight into the structure of sodium channels ... - which are responsible for ,fine-tuning, the activity of ... recent edition of the Journal of Biological Chemistry ...
Breaking Biology News(10 mins):Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Structure of sodium channels different than previously believed 2
... Tibetan sacred mountain Khawa Karpo, a verdant, snow-capped high ... world,s most exceptional areas of plant and animal diversity ... endangered snow leopard. Monsoon rains, precipitous topography dissected by ... have influenced this region, valued not only for its ...
... 12, 2012 Wake Forest Baptist Medical Center ... academic and clinical research and discoveries into marketable products ... Wake Forest Innovations, is being led by Chief Innovation ... is also President of the Piedmont Triad Research ...
... in Northern California and Oregon may be linked to a ... by scientists from the University of California, Davis. Their findings, ... could lead to a better understanding of how viruses can ... March 2010 by scientists at the UC Davis School of ...
Cached Biology News:New book details the biological and cultural diversity of Khawa Karpo, sacred mountain of Tibet 2New book details the biological and cultural diversity of Khawa Karpo, sacred mountain of Tibet 3Wake Forest Baptist Medical Center Launches Wake Forest Innovations 2Wake Forest Baptist Medical Center Launches Wake Forest Innovations 3Emerging virus in raccoons may provide cancer clues 2Emerging virus in raccoons may provide cancer clues 3
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, ... exclusive agreement with R-Pharm, a leading Russian pharmaceutical company, ... the Russian Federation , ... Independent States (CIS). Nemonoxacin is a novel antibiotic for the ...
(Date:1/14/2014)... 14, 2014 Carahsoft and CDS Federal ... 23, 2014 at 2pm EST (11am PST), “Natural Language ... focuses on how technology can turn raw, heterogeneous data ... government agencies. The online webinar will last approximately one ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2
... 2011 ReportsnReports   ... & Recovery Solutions, Electric Vehicle, Telemedicine, NFC PoS Terminal, ... store Technoavio / Infiniti Research has ... geographies. Priced differently based on the market and geography ...
... a new way to develop straight carbon nanofibers on a ... in novel biomedical research tools, solar cells, water repellent coatings ... relies on ions to ensure the nanofibers are straight, rather ... the first time, that I know of, where someone has ...
... Elsevier, a world-leading provider of scientific, technical ... National University of Singapore (NUS), a leading global ... SgCodeJam24. This "Hackathon", a 24-hour programming competition, encourages ... advance the search and discovery process of scientific ...
Cached Biology Technology:ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 2ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 3ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 4ReportsnReports - Global Hospital Information Systems, Mobile Health Applications, Electric Vehicle Market Research Reports 5Ions control shape of nanofibers grown on clear substrate 2Ions control shape of nanofibers grown on clear substrate 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 2Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 3Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 4Elsevier and the National University of Singapore Announce Winners of 24-Hour Hackathon 5
... RapidStak is a fast and ... Its high capacity and reliable ... confident walk away time than typical ... of set-up make for a seamless ...
The Wellwash 4 Mk 2 microplate washer combines flexibility, simplicity and ease of use. This reliable microplate washer meets the exacting standards of today's ELISA assay requirements....
Recombinant Rhesus Monkey IFN Alpha Activity: 2.9 x 10 8 u/mg...
... dispensers save space and organize gloves, ... garb. They are the perfect benchtop ... in labs, processing and manufacturing. Clear ... the particles they attract. Many other ...
Biology Products: