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Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
Date:9/30/2010

school, and member of the Skaggs Institute, and Daniel R. Salomon, M.D., associate professor and Medical Director of the Scripps Center for Organ and Cell Transplantation
  • $16.8 million to a center led by Raymond Stevens, Ph.D., professor in the Departments of Molecular Biology and Chemistry, together with Scripps Research investigators Assistant Professor Vadim Cherezov, Associate Professor Peter Kuhn, Professor Hugh Rosen, and Professor Kurt Wthrich
  • $5 million to the Scripps Research portion of a collaboration led by Geoffrey Chang, Ph.D., associate professor and member of the Skaggs Institute, in conjunction with Doug Rees, Howard Hughes Medical Institute investigator and Professor at the California Institute of Technology, and Michael Stowell, associate professor at the University of Colorado. The total for this grant is $11.5 million.

    Large-Scale Structure Determination

    Building on a decade of success and the solution of more than 1,000 structures, Wilson will continue to lead one of four, long-standing, large-scale PSI centers.

    The consortiumcalled the Joint Center for Structural Genomics (JCSG) and comprising scientists at the University of California, San Diego; Genomics Institute of the Novartis Research Foundation (GNF); Sanford-Burnham Medical Research Institute; and Stanford Synchrotron Radiation Lightsource (SSRL), Stanford Universitywill continue to operate its pipeline for high-throughput structure determination. Structures that the group plans to tackle over the next five years include challenging targets, such as eukaryotic proteins, as well as protein-protein, protein-RNA, protein-DNA, and other complexes.

    One theme of the center's research will be the human "microbiome," the totality of microbes in a defined environment, such as the human digestive tract.

    "Interactions of bacteria with the human body are profound and have a significant impact on maintenance of general human h
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  • Contact: Mika Ono
    mikaono@scripps.edu
    858-784-2052
    Scripps Research Institute
    Source:Eurekalert

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