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Scripps Research scientists uncover possible cocaine addiction trigger
Date:8/15/2010

. In addition to MeCP2 blunting miR-212 expression, the scientists also found that the opposite was also true that miR-212 could in turn decrease levels of MeCP2. This suggests that both are locked together in a regulatory loop. Importantly, the two had opposite effects on the expression of a particular growth factor in the brain called BDNF that regulates just how rewarding cocaine is.

While the new study fills in an important piece of the puzzle, the Kenny lab is hard at work to further increase our understanding of addiction.

"We still don't know what exactly influences the activity levels of MeCP2 on miR-212 expression," Kenny said. "Now we plan to explore what drives it whether it's environmentally driven, and if genetic and epigenetic influences are important."


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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