Navigation Links
Scripps Research scientists uncover possible cocaine addiction trigger
Date:8/15/2010

ated to consume cocaine, pointing to the protective effects of miR-212 against cocaine addiction.

"The new findings are a significant advance from this previous study," Kenny said, "because they clearly demonstrate why microRNA-212 is not always fully protective because MeCP2 regulates by how much miR-212 levels will increase in response to cocaine. This suggests that our initial findings may be central to explaining the complex process of addiction, and understanding how miR-212 signaling is regulated will be important. This study adds another level of detail to the blueprint."

A major goal of drug abuse research is to understand why certain individuals make the switch from casual to compulsive drug use and develop into addicts. Periods of easy access to the drug, along with repeated overconsumption, can quickly trigger the emergence of addiction-like abnormalities in animal models.

In the new study, the scientists first looked at the expression of MeCP2 in the brain after exposure to cocaine. They found that expression was increased in those animals given extended access to the drug.

"At that point," Kenny said, "we wanted to know if this increase was behaviorally significant did it influence the motivation to take the drug?"

Using a virus to disrupt expression of MeCP2, the scientists found that rats consumed less and less cocaine. Intriguingly, levels of miR-212 were also far higher in those animals. Because increases in miR-212 suppress attraction to cocaine, the disruption of MeCP2, in essence, put miR-212 in charge and reduced vulnerability to the drug.

"We concluded that MeCP2 may play an important role in addiction by regulating the magnitude by which miR-212 expression is increased in response to cocaine," said Kenny. "In other words, MeCP2 seems to control just how much you can protect yourself against the addictive properties of cocaine."

Intriguingly, that was not the end of the story
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research study opens the door to new class of drugs for epileptic seizures
2. Scripps research study shows infectious prions can arise spontaneously in normal brain tissue
3. Scripps Research scientists find new way to attack cancerous cells
4. Scripps research scientists determine structure of immune molecule that counteracts HIV strains
5. Scripps Research scientists break barrier to creating potential therapeutic molecules
6. Team led by Scripps Research scientists discovers bodys own molecular protection against arthritis
7. American Society for Microbiology to honor Scripps, Claude ZoBell
8. Scripps Research study overturns decade-old findings in neurobiology
9. Scripps research scientists shed light on potential treatment for Gauchers disease
10. Scripps Research team provides groundbreaking new understanding of stem cells
11. New Scripps Research and GNF study helps explain how we can sense temperatures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... protective tentacles of host anemones, but new research shows ... across the open ocean. Although the process of long-distance ... the first time that the high level exchange of ... Steve Simpson, Senior Lecturer in Marine Biology and Global ... the Australian Research Council Centre of Excellence for Coral ...
(Date:9/17/2014)... UCLA atmospheric scientists were instrumental in the creation of ... tool to classify the fire threat potential of the ... a spark into an inferno. The index was introduced ... with UCLA and San Diego Gas and Electric. , ... to "extreme" that will be used to help fire ...
(Date:9/17/2014)... and his doctoral student have designed a device based ... from fog and dew., The device could provide water ... the globe., Cheng Luo, professor in the Mechanical & ... the same College of Engineering department, published "Bioinspired Plate-Based ... (American Chemical Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Shorebird's beak inspires UT Arlington research on water collection 2
... of private health insurance and its consequent lack of ... with uterine cancer and may partly explain the mortality ... data presented at the Third AACR Conference on The ... twice as likely to die within four years compared ...
... The convergence in the coming year of three cyclical conditions ... challenges for states that depend on water from the Colorado ... I were concocting a recipe for a perfect drought, this ... and director of UCLA,s Institute of the Environment and Sustainability. ...
... Oct. 1 For the past three decades, saturated fat has ... a result dietary advice persists in recommending reduced consumption of this ... only a very limited impact on CVD risk -- causing many ... A series of research articles published in the October issue of ...
Cached Biology News:Lack of private health insurance impacted cancer survival 2Ocean conditions likely to reduce Colorado River flows during this winter's drought 2Ocean conditions likely to reduce Colorado River flows during this winter's drought 3Ocean conditions likely to reduce Colorado River flows during this winter's drought 4Think saturated fat contributes to heart disease? Think again 2Think saturated fat contributes to heart disease? Think again 3
(Date:9/18/2014)... -- Research and Markets has announced the ... 2014" report to their offering. ... professional and in-depth study on the current state of ... provides a basic overview of the industry including definitions, ... market analysis is provided for the international markets including ...
(Date:9/18/2014)... , Sept. 18, 2014  U.S. biotech company ... an exclusive license for technology developed by the ... expression in plants, including for applications in production of ... The technology was developed under the direction of ... Kultevat and former president of the Danforth Plant Science ...
(Date:9/18/2014)... , Sept. 18, 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ... previously announced concurrent but separate underwritten offerings of 10,000,000 ... the public of $2.00 per share, for expected gross ... Series A Convertible Preferred Stock at a price to ... proceeds of $20 million. Each share of Series A ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 OMICS ... the globe to participate in the ‘Open Access ... articles to OMICS Group Pharma Journals ... one of the fastest emerging Sciences, accelerating with ... healthcare services across the globe. The industry is ...
Breaking Biology Technology:Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3
... to Remain as Advisor to Company, FRAZER, Pa., ... its Executive Vice President, General Counsel &,Secretary, John E. ... effective March 31. Mr. Osborn has agreed to remain ... policy matters., "John has been an invaluable member ...
... Inc. (Nasdaq:,EVVV) will release its 2007 fourth quarter and ... market trading hours., The company will host a ... CT (8:30 a.m. ET). ev3 management will review its ... outlook, followed,by a question and answer session., The ...
... Spanish . , ANN ARBOR, Mich.---A new ... to operate a portable GPS locator, a cell phone, ... involving the University of Michigan shows. , A report ... issue of the journal Science. Authors include researchers from ...
Cached Biology Technology:Cephalon General Counsel John E. Osborn to Resign Position 2Cephalon General Counsel John E. Osborn to Resign Position 3ev3 Inc. to Report 2007 Fourth Quarter and Full-Year Financial Results and Host Conference Call on February 22, 2008 2Knee brace generates electricity from walking 2
... Pierce offers maleimide activated carrier proteins ... conjugates. Imject Maleimide Activated Carrier Proteins ... been preactivated with a heterobifunctional cross-linker ... stable, sulfhydryl-reactive carrier protein. Thus ...
...
... A perfect complement to high-speed analytical techniques, the AutoTrace SPE is a ... automates the cartridge conditioning, sample loading and elution steps for large volumes aqueous ... ... ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: