Navigation Links
Scripps Research scientists uncover new role for gene in maintaining steady weight
Date:11/23/2011

JUPITER, FL, November 23, 2011 Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes.

The study, which was published in the November 25, 2011 print edition of The Journal of Biological Chemistry, focused on the melanocortin-3 receptor (MC3R), which normally responds to signals of nutrient intake.

"What we discovered was quite a surprise," said Scripps Research Associate Professor Andrew Butler, who led the study. "We thought that the actions of the receptor expressed in the brain would be critical for metabolic homeostasis. However, what we found is that actions of the receptor expressed outside the brain appear to be equally important."

The existence of drug targets in areas outside of the central nervous system (the body's "periphery") might help in the effort to develop drugs that influence metabolism without major side effects, Butler said.

The findings were made possible by the team's development of a new transgenic animal model, where expression of the MC3R gene can be selectively "switched on" in different cell types.

In the study, the suppression of MC3R expression in the brain and peripheral tissues had a marked impact on metabolic homeostasis (equilibrium). Interestingly, mice expressing the MC3R gene in the brain only displayed an obese phenotype (physical appearance) similar to those where all types of expression was suppressed, indicating that actions of this receptor in the brain are not sufficient to protect against weight gain. The finding that loss of MC3R activity in the periphery impairs metabolic homeostasis is
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research team finds a weak spot on deadly ebolavirus
2. Scripps research scientists develop brand new class of small molecules through innovative chemistry
3. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
4. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
5. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
6. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
7. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
8. 2 Scripps Research scientists win prestigious NIH Innovator Awards
9. Scripps Research team overcomes major obstacle for stem cell therapies and research
10. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
11. Scripps Research scientists establish new class of anti-diabetic compound
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists uncover new role for gene in maintaining steady weight
(Date:12/10/2014)... California , December 9, 2014 ... with ITN,s BCARD Platform   ... cloud-based enterprise meeting scheduling solutions for business-to-business (B2B) ... the world leader in mobile near-field communication (NFC), ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
(Date:12/3/2014)... IRVINE, Calif. , Dec. 2, 2014 /PRNewswire/ ... of globally deployed, innovative test solutions for military, ... the newest version of its successful TS-900 ... the performance and features of high-end systems to ... with outstanding value compared to traditional ATE. ...
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for ... the onset of stroke remains unclear. As reported in the ... a study by Dr. Xiaoyong Sai and colleagues from Chinese ... a 5 year period from the Chinese PLA General Hospital, ...
... Global average temperatures will rise at least 4C by 2100 ... emissions are not reduced according to new research published in ... to carbon dioxide than most previous estimates. , The research ... climate sensitivity, the role of cloud formation and whether this ...
... poplar trees in Zwijnaarde, Belgium, shows that the wood of ... a more efficient way. These sugars can serve as the ... The results of the field trial have been published ... field trial of French colleagues of the INRA institute in ...
Cached Biology News:Cloud mystery solved: Global temperatures to rise at least 4°C by 2100 2Field trial with lignin modified poplars shows potential for bio-based economy 2
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
(Date:12/22/2014)... Dec. 22, 2014 GenomeDx Biosciences today announced ... Cancer Classifier, a genomic test for prostate cancer, was ... men managed by radical prostatectomy without adjuvant therapy. Although ... relatively uncommon, using tumor genomics to identify these men ... is an important advance. The study has been ...
(Date:12/22/2014)... December 22, 2014 ITRA Global, one ... occupiers of commercial real estate, has further expanded its ... in Perth and Brisbane, Western Australia, reports Mylinda Vick, ... , ITRA Global / ACORPP (Australian Corporate Property ... consultancy company providing property services to a wide range ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
Breaking Biology Technology:Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... 28 Memory,Pharmaceuticals Corp. (Nasdaq: MEMY ) today ... Qualifications Panel that the listing of the,Company,s common stock ... NASDAQ Capital Market effective with the opening of trading ... trade under the ticker,"MEMY.", The Panel has also ...
... gene-expression system at the ... conference, booth ... pioneer in,the development of cost-effective, easy-to-use gene-expression analysis,systems, announced that ... a professor in the Department of,Biochemistry and Molecular Biology at ...
... global clinical,research organization, announced that it is a ... in the "Best Contract Research Organization",category. The winners ... awards,ceremony on December 10, at the London Hilton ... Chiltern made the shortlist for this esteemed,award," commented ...
Cached Biology Technology:Memory Pharmaceuticals Provides Update on NASDAQ Listing Status 2Memory Pharmaceuticals Provides Update on NASDAQ Listing Status 3James L. Wittliff, Ph.D., FACB, to Present 'Predicting Breast Cancer Outcome with Gene Expression Signatures on the Ziplex(R) System' at the Association for Molecular Pathology Conference, October 30 2James L. Wittliff, Ph.D., FACB, to Present 'Predicting Breast Cancer Outcome with Gene Expression Signatures on the Ziplex(R) System' at the Association for Molecular Pathology Conference, October 30 3Chiltern Is a Nominee on the SCRIP CRO of the Year Award Shortlist 2
... ultimate in utility and flexibility press-to-seal silicone ... needs of the researcher. They are available ... as sheet material that can be easily ... are autoclavable and non-cytotoxic and can be ...
Argon Calibration Source...
SHEEP ANTI ESCHERICHIA COLI...
Recombinant Rat Leptin, CF...
Biology Products: