Navigation Links
Scripps Research scientists uncover new role for gene in maintaining steady weight
Date:11/23/2011

JUPITER, FL, November 23, 2011 Against the backdrop of the growing epidemic of obesity in the United States, scientists from the Florida campus of The Scripps Research Institute have made an important new discovery regarding a specific gene that plays an important role in keeping a steady balance between our food intake and energy expenditure. The study may help scientists better understand the keys to fighting obesity and related disorders such as diabetes.

The study, which was published in the November 25, 2011 print edition of The Journal of Biological Chemistry, focused on the melanocortin-3 receptor (MC3R), which normally responds to signals of nutrient intake.

"What we discovered was quite a surprise," said Scripps Research Associate Professor Andrew Butler, who led the study. "We thought that the actions of the receptor expressed in the brain would be critical for metabolic homeostasis. However, what we found is that actions of the receptor expressed outside the brain appear to be equally important."

The existence of drug targets in areas outside of the central nervous system (the body's "periphery") might help in the effort to develop drugs that influence metabolism without major side effects, Butler said.

The findings were made possible by the team's development of a new transgenic animal model, where expression of the MC3R gene can be selectively "switched on" in different cell types.

In the study, the suppression of MC3R expression in the brain and peripheral tissues had a marked impact on metabolic homeostasis (equilibrium). Interestingly, mice expressing the MC3R gene in the brain only displayed an obese phenotype (physical appearance) similar to those where all types of expression was suppressed, indicating that actions of this receptor in the brain are not sufficient to protect against weight gain. The finding that loss of MC3R activity in the periphery impairs metabolic homeostasis is
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research team finds a weak spot on deadly ebolavirus
2. Scripps research scientists develop brand new class of small molecules through innovative chemistry
3. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
4. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
5. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
6. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
7. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
8. 2 Scripps Research scientists win prestigious NIH Innovator Awards
9. Scripps Research team overcomes major obstacle for stem cell therapies and research
10. Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
11. Scripps Research scientists establish new class of anti-diabetic compound
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists uncover new role for gene in maintaining steady weight
(Date:7/10/2014)... , June 27, 2014  The American Academy ... Institute of Standards and Technology (NIST) and the ... academic research and forensic science expert members to ... is an element of the NIST,s Organization of ... among the first appointments made to the new ...
(Date:7/10/2014)... 2014 Smart technology emphasis grows in ... improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... Apple Inc. (NASDAQ: AAPL ), Visa Inc. (NYSE: ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on ... second series of 30 second spots on CNBC for its ...
(Date:7/10/2014)... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the growing ... was interviewed on July 1 st on the Downtown ... Mr. Pereira discusses the company,s next generation smart wallet with ... Wocket™ aims to replace a traditional wallet with a new ... tells Gino he has never heard of the Wocket and ...
Breaking Biology News(10 mins):Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 2Ten Members of the American Academy of Forensic Sciences Appointed to Forensic Science Standards Board (FSSB) 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4
... CAMBRIDGE, Mass., July 12, 2011 GNS Healthcare, ... Institute (NCI) to accelerate lung cancer research with a ... in huge data sets assembled from imaging, genetics, pathology, ... patients will respond to a given treatment. ...
... 07/07/11, Clearwater Beach, FL. New research findings ... Society for the Study of Ingestive Behavior (SSIB), the foremost ... behavior, finds that ghrelin, a natural gut hormone that stimulates ... cues to alter dopamine levels within the striatum, a critical ...
... China BGI (previously known as the Beijing Genomics Institute), ... it was among the research organizations comprising the Potato Genome ... of the tuber crop potato, published as an Advance Online ... This study marks an important milestone in Potato ( Solanum ...
Cached Biology News:GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 2GNS Healthcare Collaborates with NCI in New Approach to Lung Cancer; Supercomputer Analysis to Aid in Matching Targeted Drugs to Patients 3BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research 2BGI contributes whole genome sequencing and bioinformatics expertise to potato genome research 3
(Date:7/10/2014)... July 10, 2014  Franciscan St. Anthony ... capnography for respiratory monitoring outside the operating ... leaders in embracing state-of-the-art patient safety technology. ... are breathing and can alert medical caregivers ... the amount of carbon dioxide the patient ...
(Date:7/10/2014)... DALLAS , July 10, 2014  Kainos Capital, ... consumer brands, today announced that it has acquired the ... stake in the business. Terms of the transaction were ... loss and meal replacement business that markets ready-to-drink shakes, ... North America and in the ...
(Date:7/10/2014)... , July 10, 2014 Research ... addition of the "International Photonic Integrated Circuit ... Forecasts to 2019" report to their offering. ... The concept of photonic integration traces its ... century. The promise of photonic integration went unexplored ...
(Date:7/10/2014)... April 15, 2014 -- According to the International ... nuclear security comes from terrorists acquiring sufficient quantities ... construct a crude nuclear explosive device. The IAEA ... trafficking have involved gram-level quantities, which can be ... According to a new study appearing this week ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Kainos Capital Acquires Slim-Fast From Unilever 2International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Sensitive detection method may help impede illicit nuclear trafficking 2
... $50,000 planning grant from the Ewing Marion Kauffman ... plan for cross-campus entrepreneurship in a national competition among ... was selected by the Foundation to compete for further ... Entrepreneurial Initiative. , ,Provost Peter Spear and School ...
... complaints of poor service from Wisconsin customers two years ago ... ,Paul La Schiazza, president of SBC's Wisconsin division said that ... was not a small local company, but a large corporation ... SBC Communications Inc. announced that SBC Ameritech of Wisconsin would ...
... offer an integrated PAC (picture achieving and communications) and ... of hospitals and imaging centers. , ,"The acquisition ... our evolution as a healthcare software and services company ... market," said Rich Linden, Merge eFilm president and CEO. ...
Cached Biology Technology:UW-Madison Receives Grant to Develop Entrepreneurship Proposal 2SBC is Here to Stay 2Merge eFilm to buy Ohio firm in $14M Deal 2Merge eFilm to buy Ohio firm in $14M Deal 3
... PolarScreen Progesterone Receptor (PR) Competitor Assay ... screening novel progesterone receptor binding compounds ... assay utilizes a fusion of glutathione ... of human progesterone receptor [PR-LBD(GST)] and ...
... acid analysis standard is a ... salts; molecular weights range from ... is provided for use with ... the organic acid analysis kit ...
... Imaging Systems group announces the availability ... Imaging Systems, featuring high resolution cooled ... luminescence, radiographic and chromogenic imaging capability. ... and 10x optical zoom lens provides ...
... The RapidVUE is a particle shape and ... has been designed with the utmost simplicity in ... sample delivery module and an optical bench. The ... allows for easy upgrade for different applications such ...
Biology Products: