Navigation Links
Scripps Research scientists solve mystery of nerve disease genes
Date:7/4/2011

inherit only one faulty copy of the GARS gene from one parent to get the disease.

The GARS gene holds the instructions for producing an enzyme called glycyl-tRNA synthase (GlyRS), which is vital to the process by which amino acids, the building blocks of proteins, are attached to one another during protein synthesis. So far, scientists have found 11 different kinds of mutations in the GARS gene that cause CMT type 2D. Some of the mutations affect the protein-building function of the GlyRS enzyme, but others don't, suggesting that a change in enzyme activity is not what causes CMT.

Thus, scientists have been trying to find a common feature shared by all GlyRS mutants that might explain the disease mechanism.

Structures in Solution

To find this common feature, Yang and colleagues turned to the three-dimensional structure of GlyRS. In 2007, they published the X-ray crystal structure of the wild-type protein and one of the mutants, but the structures were not all that different from each other (PNAS 104:11239-44, 2007).

"When we compared the wild type with the mutant, we did not find dramatic conformational change," said Weiwei He, a Scripps Research graduate student who joined Yang's lab and took on the project around the time of the 2007 paper's publication. "We thought maybe it was because of the crystal packing."

X-ray crystallography requires obtaining high amounts of a protein and packing the protein molecules into crystals that are bombarded with X-rays to determine the positions of all the atoms. This preparation, Yang and He reasoned, may mask any subtle conformation changes in a protein. "That is why we thought to look at the structure in solution, under more physiological conditions," said He.

In collaboration with Hui-Min Zhang, a postdoctoral fellow in the laboratory of Alan Marshall at the National High Magnetic Field Laboratory at Florida State University, Yang and He used a method to
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
2. Scripps study finds plastic in 9 percent of garbage patch fishes
3. Scripps Research Institute Scientist Knighted by Italian Republic
4. Scripps Research team sheds new light on how blood clots form
5. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
6. Scripps Research scientist wins $1.9 million grant to study malaria
7. Scripps Research scientists find way to block stress-related cell death
8. Scripps Research scientists find key mechanism in transition to alcohol dependence
9. Scripps Research scientists create new genetic model of premature aging diseases
10. Scripps Research scientists identify mechanism of long-term memory
11. Scripps Research scientists uncover new DNA role in modifying gene function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Dec. 18, 2014   LaunchKey , the first ... post-password and Internet of Things era, today announced the ... venture round was led by Metamorphic Ventures with participation ... Partners, VegasTechFund, and others.  LaunchKey has raised $4 million ... expand its team and bring LaunchKey to market in ...
(Date:12/17/2014)... DUBLIN , Dec. 16, 2014 Research ... announced the addition of the "Global Chemical ... http://photos.prnewswire.com/prnh/20130307/600769 ... is the increasing demand for medical sensors in ... patient data for quick and correct diagnosis during ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... our way out of ageing," says Nancy Ross, a McGill geography ... maybe some hearing loss, maybe lose some mobility ageing is ... lead author of a new study about how socio-economic and educational ... a lifetime. "My research looks at how poverty ...
... type of gorilla will receive a helping hand from Newman,s ... $150,000 grant to help save the Grauer,s gorilla in the ... The grant will help equip and support park rangers (or ... National Park, a World Heritage site that is now threatened ...
... This press release is available in German . ... diseases: the minute soot particles from the exhaust gas of ... In order to nevertheless keep the harmful effects to one,s ... for diesel soot have been lowered drastically step by step, ...
Cached Biology News:Lifelong gap in health between rich and poor set by age 20 2Wildlife Conservation Society receives $150,000 grant from Newman's Own Foundation to save gorillas 2Pan-European research project for clean air 2Pan-European research project for clean air 3
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 iLab ... announced the appointment of Siri Bryant as the new ... new Director of Core Implementations. These two new leadership ... outstanding customer service by ensuring that iLab continues to ... “In the last four years, iLab has been deployed ...
(Date:12/19/2014)... BURLINGTON, Mass. , Dec. 18, 2014  Decision ... dental biomaterial market will grow moderately through ... implant procedures and growing awareness of dental biomaterials all ... underdeveloped markets such as China ... incomes will bring dental procedures within reach for a ...
(Date:12/17/2014)... (PRWEB) December 16, 2014 The ... since 2013, which is why IBISWorld updated its original ... continues to benefit from an intensified focus on environmental ... for new emission standards for power plants and a ... According to IBISWorld Industry Analyst Sarah Kahn, “a range ...
(Date:12/17/2014)... N.J. (PRWEB) December 17, 2014 ... (Euronext: IPN; ADR: IPSEY), today announced ... (referred to as Somatuline®) was approved by the ... treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in adult ... advanced or metastatic disease to improve progression-free survival ...
Breaking Biology Technology:iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 2Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 3Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 4Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 5Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 6Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 7Ipsen Announces the FDA Approval of Somatuline® Depot® (lanreotide) Injection for the Treatment of Gastroenteropancreatic Neuroendocrine Tumors 8
... Now in ... leaders from around the globe to discuss pain management, preclinical and clinical development of new ... Minneapolis, MN ... Summit , set to take place on October 4th-5th, 2010 in Philadelphia, has been announced., ...
... CAMBRIDGE, England , May 25, 2010 Executives ... announced today,an extension of the agreement under which O2h provides multi-FTE -synthetic,chemistry ... , , ... Head of Chemistry said, "We are happy to have signed,this new contract ...
... EXTON, Pa. , May 25 Fibrocell Science, ... the development of autologous cell therapies for aesthetic, medical and ... with Irish Voice newspaper and ... and Chief Financial Officer Declan Daly as a ...
Cached Biology Technology:Scientific and Business Leaders to Discuss Challenges Facing Developers of Pain Therapeutics at Arrowhead's 4th Annual Pain Therapeutics Summit 2Heptares Therapeutics Extends Multi-FTE Chemistry Collaboration With Oxygen Healthcare (O2h) 2Heptares Therapeutics Extends Multi-FTE Chemistry Collaboration With Oxygen Healthcare (O2h) 3The Irish Government and the Irish Voice Recognize Fibrocell Science, Inc.'s Declan Daly as 'Irish Life Science 50' Member 2
Immunogen: Synthetic peptide: N(171) H G F L S A D Q QL I K(183) Storage: -20 C, Avoid Freeze/Thaw Cycles...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
HIV-1 TAT (vN-21)...
Request Info...
Biology Products: