Navigation Links
Scripps Research scientists show prions mutate and adapt to host environment
Date:12/17/2010

e faster an evolutionary advantage and become the dominant strain. This new population also contains variants, one of which may be selected over others when transferred to a different host.

"The result is that prions, although devoid of genetic material, behave similarly to viruses and other pathogens, in that they can mutate and undergo evolutionary selection," Weissmann said. "They do it by changing their fold, while viruses incur changes in their nucleic acid sequence."

Diverse Yet Related

The new study suggests that prion populations constitute a "quasi-species" similar in nature to RNA viruses and retroviruses, such as flu viruses and HIV.

The idea of a quasi-species was first conceived by Manfred Eigen, a German biophysicist who won the Nobel Prize in Chemistry in 1967. Basically, a quasi-species is a complex, self-perpetuating population of diverse and related entities that act as a whole. It was Weissmann, however, who in 1978 provided the first confirmation of the theory through the study of a particular bacteriophage a virus that infects bacteria while he was director of the Institut fr Molekularbiologie in Zrich, Switzerland.

But that's where the comparison ends, Weissmann said.

"The fact that they behave like viruses doesn't mean they're anything like a virus," he said. "A bicycle is like a car in that it gets you from one place to the other, but they're not the same. The end effect is the same, however. Prions and viruses are both able to change their structure to survive."


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps scientists see the light in bizarre bioluminescent snail
2. Scripps Research scientists redefine the role of plasma cells in the immune system
3. Judy and J. John Goodman give $50,000 gift to Scripps Florida
4. New Scripps Florida scientist awarded pair of unconventional grants
5. Scripps Research scientists identify new mechanism regulating daily biological rhythms
6. Scripps Research team watches formation of cells protein factories for first time
7. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
8. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
9. Scripps Research study challenges conventional theory of modern drug design
10. Scripps Research scientists develop novel test that identifies river blindness
11. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... EAST LANSING, Mich. – As bodies decompose, their ... Deciphering the clues they provide could mean the ... murder. , Michigan State University is using a ... to help Detroit death-scene investigators examine these changing ... such as geographical location of death, gender, race, ...
(Date:10/29/2014)... Virtually all organisms in the living world compete ... differ strongly in how much they invest into ... and eager to get access to high-quality resources, ... prudent use of the lower-quality resources that are ... competitiveness in animal and human societies seems to ...
(Date:10/28/2014)... news release is available in German . ... close relatives, the chimpanzees, acquire sufficient food when times ... National Park in Côte d,Ivoire researchers of the Max ... a clear example of how great apes can acquire ... show that chimpanzees make their sleeping nests more en ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Evolution of competitiveness 2Evolution of competitiveness 3The early chimp gets the fig 2The early chimp gets the fig 3
... 2007Professor Gilles Gauthier of Universit Lavals Centre dtudes nordiques ... up the ArticWOLVES project as part of International Polar ... the research project aims to better understand the impact ... polar ecosystems. Dating back to the 1960s, Centre ...
... 24, 2007) New research published in the October ... Surgeons suggests that pregnant women suspected of having appendicitis ... the appendix) that can result in early delivery or ... the need to require more accurate diagnosis to avoid ...
... The vast majority of patients who had ... did not need mitral valve surgery three years ... improved function of the left ventricle (commonly known ... week at the Cardiovascular Research Foundations (CRF) nineteenth ...
Cached Biology News:$2.8 million for research into the impact of climate change on tundra wildlife 2Pregnant women at risk for unnecessary operations due to misdiagnosis of appendicitis 2New data shows benefits of MitraClip for patients with mitral regurgitation 2New data shows benefits of MitraClip for patients with mitral regurgitation 3
(Date:10/25/2014)... October 23, 2014 ViaDerma, ... pharmaceutical company devoted to bringing new products to ... 2015. , ViaDerma has developed an innovative, patent-pending ... rapid mass transfer of pharmaceutical active ingredients to ... provide immediate localized therapy. The transdermal delivery method ...
(Date:10/25/2014)... Va. (PRWEB) October 24, 2014 ... the nation’s leading nonprofit authority on the ... healthcare information exchange, announces its appointment of four ... Workgroup. The workgroup leaders include:, , ... ,     Erik Pupo, Specialist Leader, Deloitte Consulting ...
(Date:10/25/2014)... A new way to produce engineered skin not ... grafting technologies, it also speeds up the healing process, ... the October issue of STEM CELLS Translational Medicine, could ... result from severe burns and chronic wounds. , A ... These wounds heal by contraction, with epithelization (the process ...
(Date:10/25/2014)... Oct. 24, 2014  RegeneRx Biopharmaceuticals, Inc. (OTCBB: RGRX) ("the ... the Fourth International Symposium on Thymosins in Health and ... "When thymosin beta 4 (TB4) linked with ... peritoneal cavity in a rodent model of stroke, it ... brain parenchyma (the functional tissue of the brain).   The ...
Breaking Biology Technology:ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2
... more convenient security to residences and private offices with their state-of-the-art ... businesses, hospitals, schools and the military is now accessible to the ... ... same innovative biometric technology used to enhance Hollywood films like Mission ...
... 27 MichBio, the association for,Michigan,s biosciences industry, ... to its program on day one of its ... Rock Financial ShowPlace Novi, MI. The,event will provide ... bioscience technologies and emerging companies to an audience ...
... Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced today the company,s,participation and ... investor conferences in September., Conference: NewsMakers ... Millennium Broadway Hotel & Conference Center ... West 44th Street, New York Presentation Date: Thursday, September ...
Cached Biology Technology:BIOLOCK(TM) USA Launches Affordable Fingerprint door Locks for Homes and Offices 2Start-Up and Emerging Biotech Companies Will Tell Their Stories at Biosciences Showcase Planned for MichBio Expo 2Alexza Pharmaceuticals Announces Upcoming Webcasts and Conference Participation 2Alexza Pharmaceuticals Announces Upcoming Webcasts and Conference Participation 3
...
... formation of phosphodiester bonds in the presence ... hydroxyl and 5' phosphate termini. The unique ... can be performed in 5 minutes (1). ... this enzyme. A T4 DNA Ligase ...
Porcine Aortic Endothelial Cells (PAOEC) (>500,000 cells)...
Bovine Endometrium Epithelial Cells (BEnEpC) (>500,000 cells)...
Biology Products: