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Scripps Research scientists show prions mutate and adapt to host environment
Date:12/17/2010

JUPITER, FL, December 16, 2010 Scientists from the Florida campus of The Scripps Research Institute have shown that prions, bits of infectious protein that can cause fatal neurodegenerative disease such as bovine spongiform encephalopathy (BSE) or "mad cow disease," have the ability to adapt to survive in a new host environment.

In this regard, although they lack DNA and RNA, they behave much like viruses, producing distinct self-perpetuating structural mutations that provide a clear evolutionary advantage.

The study was published this week in the online Early Edition the journal Proceedings of the National Academy of Sciences.

"We found that when a particular prion strain is transferred from brain cells to a different cell line, its properties gradually change, giving rise to a variant strain that is better adapted to this new cellular environment," said Charles Weissmann, M.D., Ph.D., the head of Scripps Florida's Department of Infectology, who led the study. "If those same prions are subsequently transferred to another cell line, they change again, adapting to these new host cells. And if returned to the brain, the prions gradually regain their original properties. We found physical evidence that, at least in one case, the fold of the prion changed when its properties changed."

Darwinian Evolution Without DNA

These new findings come approximately one year after Weissmann and colleagues published a study in the January 1, 2010 edition of the journal Science that showed that prions were capable of Darwinian evolution.

That earlier study also showed that prions can develop large numbers of mutations and that these mutations can bring about such evolutionary adaptations as drug resistance, a phenomenon previously known to occur only in bacteria and viruses. This study also suggested that the normal prion protein which occurs naturally in mammalian cells may prove to be a more effective thera
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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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