Navigation Links
Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
Date:7/19/2012

JUPITER, FL, July 19, 2012 A new study by scientists on the Florida campus of The Scripps Research Institute shows, in cell culture, a natural compound can virtually eliminate human immunodeficiency virus (HIV) in infected cells. The compound defines a novel class of HIV anti-viral drugs endowed with the capacity to repress viral replication in acutely and chronically infected cells.

The HIV/AIDS pandemic continues to affect 34 million individuals worldwide, including more than 3 million children, according to the World Health Organization. Current treatment involves the use of several antiretroviral drugs, termed Highly Active Antiretroviral Therapy (HAART), which can extend the life expectancy of HIV-positive individuals and decrease viral load without, however, eradicating the virus.

"We know that there are reservoirs of HIV that aren't being eliminated by current treatment and that keep replenishing the infection," said Susana Valente, a Scripps Research biologist who led the study. "Viral production from these cellular reservoirs that harbor an integrated viral genome is not affected by current antiretroviral drugs, which only stop novel rounds of infection. The compound in the current study virtually eliminates all viral replication from already-infected cells where HIV hides."

The new study, published in the July 20, 2012 issue of the journal Cell Host and Microbe, focused on a medically promising compound known as Cortistatin A. This natural product was isolated in 2006 from a marine sponge, Corticium simplex, discovered more than 100 years ago. In 2008, Scripps Research chemist Phil Baran and his team won the global race to synthesize the compound, presenting an efficient and economical method.

In the new study, Valente and her colleagues collaborated with the Baran lab, using a synthetic version of the compound, didehydro-Cortistatin A, to study the compound's effect on two strains of HIV. The strains
'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research Institute wins $77 million to develop AIDS vaccine center
2. Scripps Florida scientists identify critical quality control for cell growth
3. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
4. Scripps Research Institute announces five-year research collaboration with Bristol-Myers Squibb
5. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
6. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
7. Plastic trash altering ocean habitats, Scripps study shows
8. Scripps Florida scientists identify neurotranmitters that lead to forgetting
9. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
10. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
11. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists show potent new compound virtually eliminates HIV in cell culture
(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... a part of the National Institutes of Health ... million to fund three new Institutional Development Awards ... concentrating on one general area of research ... research infrastructure. The IDeA program is designed to ...
... altering the Earths chemistry. Many of societys most pressing ... from human activities that disrupt natural chemical cycles. Moving ... reversing actions that have such a huge impact on ... of the Institute of Ecosystem Studies, Dr. William H. ...
... -- Three researchers at the Albert Einstein College of ... Research Foundation (BCRF). Drs. Thomas Rohan, Susan Horwitz and ... its ongoing effort to support the advancement of breast ... is its mission, which is to achieve prevention and ...
Cached Biology News:NIH grants $33 M in institutional development awards to 3 states 2Biogeochemistry -- A window into the Earth's ecological health 2Einstein researchers receive grants totaling $700,000 for innovative breast cancer research 2
(Date:12/13/2014)... Taiwan (PRWEB) December 12, 2014 Trend ... indicators in overall global economic growth, Eugene Arthurs, CEO ... photonics , said in a featured talk at OPTIC ... December at the National Chung Hsing University in Taichung. ... being integrated into future energy supplies and soon to ...
(Date:12/13/2014)... New York, New York (PRWEB) December 13, 2014 ... expansion of its global network and Cold Chain capabilities, ... new Control Tower in Paris, France, to serve Life ... brand new facility equipped with a controlled-ambient warehouse, will ... in-transit storage for vaccines and investigational drugs, patient-clinical specimens, ...
(Date:12/13/2014)... ROCHESTER, N.Y. , Dec. 12, 2014 ... engaged in the discovery and development of ... neurodegenerative diseases, today announced publication of a ... microglia, and inhibits remyelination in neurodegenerative disease" ... journal Neurobiology of Disease*.  The publication highlights ...
(Date:12/12/2014)... Graphite Metallizing Corporation, the manufacturer of ... process equipment, has appointed Kirk Staller as Sales Engineering ... Staller holds a B.S. degree from Purdue University and ... place, much of it with a manufacturer of centrifugal ... office. , “We are pleased to have ...
Breaking Biology Technology:Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Quick Opens Office in France to Serve Life Science Community In France and Neighboring French-Speaking Countries 2Vaccinex announces publication of preclinical studies with an anti-SEMA4D antibody in animal models of neuroinflammatory and demyelinating disease 2Kirk Staller Joins Graphite Metallizing Corporation 2
... , No more siRNA design and testing , ... 1 day , , ... , Simplify Your Gene , ... use of small interfering RNAs (siRNAs) to induce targeted gene , ...
... Ambion scientists have engineered a mutant form of ... full-length cDNA. This engineered reverse transcriptase, , <A ... href="http://www.ambion.com/catalog/CatNum.php?2048">ArrayScript , (patent pending), ... than wild type RTs, and rivals even the newest engineered RTs on , ...
... offers a complete Gene Expression Profiling Service* for Affymetrix , ... Service offering, , no project is too ... consultation with Ambion's team of experienced array and informatics ... long history of providing innovative, , high ...
Cached Biology Technology:Avoid siRNA Design Altogether! 2Avoid siRNA Design Altogether! 3ArrayScript RT: Maximize Yields of Full-length cDNA 2ArrayScript RT: Maximize Yields of Full-length cDNA 3Ambion Offers Gene Expression Profiling Service 2Ambion Offers Gene Expression Profiling Service 3
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z71,448-8) or contact ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: