Navigation Links
Scripps Research scientists reveal key mechanism governing nicotine addiction
Date:1/30/2011

ay isn't functioning properly, you simply take more. Our data may explain recent human data showing that individuals with genetic variation in the α5 nicotinic receptor subunit are far more vulnerable to the addictive properties of nicotine, and far more likely to develop smoking-associated diseases such as lung cancer and chronic obstructive pulmonary disease."

A Previously Unknown Pathway Inhibits Motivation

Tobacco smoking is one of the leading causes of death worldwide, with more than five million people dying each year as a result of it, according to statistics cited in the study. Smoking is considered the cause of more than 90 percent of lung cancer deaths. Scientists have established that a tendency towards smoking can be inherited more than 60 percent of the risk of becoming addicted to nicotine can be laid at the door of genetic factors.

Nicotine is the major addictive component of tobacco smoke, and nicotine acts in the brain by stimulating proteins called nicotinic acetylcholine receptors (nAChRs). These nAChRs are made up of different types of subunits, one of which is the α5 subunitthe focus of the new study.

In their experiments, the Scripps Research scientists set out to determine the role of nAChRs-containing α5 subunits (α5* nAChRs) in regulating nicotine consumption.

First, the team assessed the addictive properties of nicotine in genetically altered mice lacking α5* nAChRs. The results showed that when these "knockout" mice were given access to high doses of nicotine, they consumed much larger quantities than normal mice. Next, to determine if the subunit was responsible for the sudden shift in appetite for nicotine, the scientists used a virus that "rescued" the expression of α5* nAChRs only in the medial habenula and areas of the brain into which it projects. The results showed the nicotine consumption patterns of the knockout mice returned to a normal range. <
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team creates new synthetic compound with HIV-fighting promise
2. Scripps Research and Vanderbilt to launch joint institute
3. Scripps Research chemist devises new method to quantify protein changes
4. Scripps Research scientists identify key interaction in hepatitis C virus
5. Scripps Research scientist uncovers switch controlling protein production
6. Scripps Research scientists show prions mutate and adapt to host environment
7. Scripps scientists see the light in bizarre bioluminescent snail
8. Scripps Research scientists redefine the role of plasma cells in the immune system
9. Judy and J. John Goodman give $50,000 gift to Scripps Florida
10. New Scripps Florida scientist awarded pair of unconventional grants
11. Scripps Research scientists identify new mechanism regulating daily biological rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 IriTech, a ... a member of the Texas Instruments Design Network, announced ... has demonstrated its IriShield USB MK2120U device during ... facility for pension distribution. The iris ... to be marketed in India ...
(Date:3/12/2015)... March 12, 2015 WHEN:Tuesday, March 17, 2015 ... http://bit.ly/1G7Os0L . SPEAKERS: , Frost & Sullivan ... http://photos.prnewswire.com/prnh/20150311/181111 Biometric companies must ... in several different markets and industries. This is ... an uptrend. Join Frost & ...
(Date:3/10/2015)... NEW YORK , March 10, 2015  Continuing ... and the Unexpected, Hammacher Schlemmer introduces The Eye ... user,s identity before granting access to secure websites or ... trusted to verify travelers at international borders, the device ... 240 distinctive pattern points of the iris, converting them ...
Breaking Biology News(10 mins):Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 2Biometrics Key to Future Growth in Healthcare, Retail and Financial Markets 3Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... working to create "protocells" primitive synthetic cells consisting ... compartment have accomplished an important step towards their ... Science , the investigators describe a solution to ... potential incompatibility between a chemical requirement of RNA copying ...
... a team of UC San Diego biophysicists has discovered ... to multiply in the presence of antibiotics, a growing ... United States. , Two months ago, the Centers for ... that antibiotic-resistant bacteria last year caused more than two ...
... have developed a series of techniques to create a ... the alcohols and amines used in the drug and ... safer and more economical and environmentally friendly than traditional ... extensive supply of iron the fifth most abundant ...
Cached Biology News:Researchers find a missing component in effort to create primitive, synthetic cells 2Researchers find a missing component in effort to create primitive, synthetic cells 3Quantitative approaches provide new perspective on development of antibiotic resistance 2Quantitative approaches provide new perspective on development of antibiotic resistance 3Iron-based process promises greener, cheaper and safer drug and perfume production 2
(Date:4/1/2015)... , April 1, 2015 ... company developing novel biological drugs to treat cancer, ... to announce the appointment of Christina Coughlin ... be responsible for providing medical and regulatory leadership ... Company. Dr. Coughlin has extensive experience ...
(Date:3/31/2015)... KY (PRWEB) March 31, 2015 ... 50 schools for online bachelor’s of criminal justice ... to connecting people to inspiring ideas and high ... an e-mail to the University. We are confident ... University.” , This is the site’s first ...
(Date:3/31/2015)... 2015  Bayer HealthCare (Bayer) has expanded its ... of Technology (MIT) and Harvard University to include ... this new part of the alliance is to ... new cardiovascular therapies. "We are excited ... to the area of cardiovascular genomics to discover ...
(Date:3/31/2015)... , March 31, 2015  University of ... Rogers will deliver the plenary session address on ... International Microwave Symposium (IMS) , kicking off a week ... growth at the intersection of RF and microwave technologies ... Assemblies of Radios, Sensors and Circuits for the Skin," ...
Breaking Biology Technology:Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 2Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 3Immunocore Appoints Dr. Christina Coughlin as Chief Medical Officer 4EKU Ranked in Top 50 Among Online Criminal Justice Degrees 2Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 2Bayer HealthCare Expands Collaboration with Broad Institute of MIT and Harvard to Develop Therapies for Cardiovascular Disease 3Health and Engineering Converge at the 2015 International Microwave Symposium 2Health and Engineering Converge at the 2015 International Microwave Symposium 3
... MILWAUKEE--- GE Healthcare , a $10 billion provider ... information technology, announced today that it has received ... healthcare industry authority, KLAS Enterprises for the second ... called Centricity(R) Pharmacy Information System, was recognized in ...
... OASYS , a leading developer of K-12 software ... Behind management, recently announced their online, ASP software ... (IEPs) and monitors the progress of children with ... in 16 Wisconsin school districts during 2003, provides ...
... Third Wave Technologies Inc , a maker of molecular ... 2D6 analysis panel, which provides clinical trial laboratories with ... for the important 2D6 gene. , ,The panel is ... the ability to configure custom assay panels. The panel ...
Cached Biology Technology:Third Wave Releases Gene Test 2