Navigation Links
Scripps Research scientists reveal key mechanism governing nicotine addiction
Date:1/30/2011

JUPITER, FL January 25, 2011 Embargoed by the journal Nature until January 30, 1 PM Eastern time Scientists from the Florida campus of The Scripps Research Institute have identified a pathway in the brain that regulates an individual's vulnerability to the addictive properties of nicotine. The findings suggest a new target for anti-smoking therapies.

The study appeared January 30, 2011, in an advance, online issue of the journal Nature.

In the study, the scientists examined the effects of a part of a receptor (a protein molecule to which specific signaling molecules attach) that responds to nicotine in the brain. The scientists found that animal models with a genetic mutation inhibiting this receptor subunit consumed far more nicotine than normal. This effect could be reversed by boosting the subunit's expression.

"We believe that these new data establish a new framework for understanding the motivational drives in nicotine consumption and also the brain pathways that regulate vulnerability to tobacco addiction," said Scripps Research Associate Professor Paul Kenny, who led the study. "These findings also point to a promising target for the development of potential anti-smoking therapies."

Specifically, the new study focused on the nicotinic receptor subunit α5, in a discrete pathway of the brain called the habenulo-interpeduncular tract. The new findings suggest that nicotine activates nicotinic receptors containing this subunit in the habenula, triggering a response that acts to dampen the urge to consume more of the drug.

"It was unexpected that the habenula, and brain structures into which it projects, play such a profound role in controlling the desire to consume nicotine," said Christie Fowler, the first author of the study and research associate in the Kenny laboratory. "The habenula appears to be activated by nicotine when consumption of the drug has reached an adverse level. But if the pathw
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team creates new synthetic compound with HIV-fighting promise
2. Scripps Research and Vanderbilt to launch joint institute
3. Scripps Research chemist devises new method to quantify protein changes
4. Scripps Research scientists identify key interaction in hepatitis C virus
5. Scripps Research scientist uncovers switch controlling protein production
6. Scripps Research scientists show prions mutate and adapt to host environment
7. Scripps scientists see the light in bizarre bioluminescent snail
8. Scripps Research scientists redefine the role of plasma cells in the immune system
9. Judy and J. John Goodman give $50,000 gift to Scripps Florida
10. New Scripps Florida scientist awarded pair of unconventional grants
11. Scripps Research scientists identify new mechanism regulating daily biological rhythms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)... Passwords have proven futile for securing ... U.S. Office of Personnel Management breach. Biometric authentication ... but developers and end-users are concerned about how ... Biometrics-as-a-Service provider HYPR Corp. announced today the general ... party integration. A video overview ...
(Date:7/13/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... focused on the growing mobile commerce market, announced ... for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND SYSTEM. ... secure method to make payments.  With this patent, ... with its groundbreaking voice-direct payment patent application, with ...
(Date:7/9/2015)... Calif. , July 9, 2015  Unchained ... today announcing its acquisition of Avid Nano. Avid ... light scattering (DLS) systems.    Also ... smallest, fastest and easiest to use protein sizing ... that measures a protein,s hydrodynamic size, size distribution, ...
Breaking Biology News(10 mins):HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2
... has found that the red squirrel population along the ... outbreak of squirrelpox in 2008. Researchers from the ... been monitoring the red squirrel population at the Seaforth ... 85% fall in the red squirrel population. Squirrel ...
... STOCKHOLM , November 26, 2013 ... et en extérieur dans plus de 30 pays ... en Suède, vient de lancer Trax, un traceur GPS ... appareil intelligent et son application permettent aux utilisateurs de ...
... Barbara, Calif.) Sepsis, the body,s response to severe ... and HIV/AIDS combined. On average, 30 percent of those ... by Jamey Marth, director of UC Santa Barbara,s Center ... Institute, reports a new method to increase survival in ...
Cached Biology News:Red Squirrels showing resistance to squirrelpox 2Suivez vos enfants et vos animaux domestiques grâce à TRAX, le nouveau traceur GPS intelligent 2Suivez vos enfants et vos animaux domestiques grâce à TRAX, le nouveau traceur GPS intelligent 3UCSB biomedical scientist discovers a new method to increase survival in sepsis 2UCSB biomedical scientist discovers a new method to increase survival in sepsis 3
(Date:7/30/2015)... ... July 30, 2015 , ... The 2015 Market Research Report on the ... state of the global Propanol market with a focus on the Chinese situation. Major ... Mitsui Chemicals, Oxea, ISU Chemical, Sanofi, Royal Dutch Shell, LG Chem and Zhejiang Xinhua ...
(Date:7/30/2015)... SAN DIEGO, July 30, 2015   Senomyx , ... proprietary taste science technologies to discover, develop, and commercialize ... supply industries, today reported financial results for the second ... half of 2015, we remain on track to achieve ... and Chief Executive Officer of the Company. "Since our ...
(Date:7/30/2015)... Pa. , July 30, 2015  Discovery ... that it has received the second $1.0M tranche ... Innovation Research (SBIR) grant valued at up to ... company,s aerosolized KL4 surfactant as a potential medical ... injury.  Discovery Labs was awarded an initial $1.0 ...
(Date:7/29/2015)... July 30, 2015 Sanofi, ... publie ses résultats pour le premier semestre 2015. ... les résultats. Visionner l,interview vidéo et ... Au sommaire de l,interview :  ... Moteurs de croissance - Diabète ...
Breaking Biology Technology:Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3
... Cell Therapeutics, Inc. ("the Company") (Nasdaq and MTA: CTIC) ... up results from the Company,s pivotal phase III PIX301 ... recent Marketing Authorization Application (the "MAA") currently under review ... end-of-study results showed continued improvement in the trial,s primary ...
... 2010 Gentiva Health Services, Inc. (Nasdaq: ... and hospice services, announced today that it has scheduled a ... 10:00 a.m. ET to provide an update on its 2011 ... of December 16 before pre-market trading. The December ...
... 3, 2010 Nu Skin (NYSE: NUS ... physical vitality is improved through nutritional strategies that influence ... the First World Congress on Targeting Mitochondria: Strategies, Innovation ... Nu Skin,s innovative ageLOC science we have successfully identified ...
Cached Biology Technology:New Pixantrone Data Presented at Meetings at American Society of Hematology Conference 2New Pixantrone Data Presented at Meetings at American Society of Hematology Conference 3New Pixantrone Data Presented at Meetings at American Society of Hematology Conference 4New Pixantrone Data Presented at Meetings at American Society of Hematology Conference 5New Pixantrone Data Presented at Meetings at American Society of Hematology Conference 6Gentiva® Health Services Schedules 2011 Outlook Conference Call and Webcast for Thursday, December 16, 2010 2Gentiva® Health Services Schedules 2011 Outlook Conference Call and Webcast for Thursday, December 16, 2010 3Nu Skin Scientists Present ageLOC Research at International Conference on Mitochondria 2Nu Skin Scientists Present ageLOC Research at International Conference on Mitochondria 3
S-100 alpha/beta chain (8B10)...
... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ... mm, No. of sidearm 4 ...
... 15(S)-15-methyl PGF2α is a ... It is a potent uterine ... be administered intramuscularly to induce ... reduces serum progesterone concentrations when ...
TGase3 (S-20)...
Biology Products: