Navigation Links
Scripps Research scientists redefine the role of plasma cells in the immune system
Date:11/30/2010

La Jolla, CA November 29, 2010 - For Immediate Release A team of scientists from The Scripps Research Institute have uncovered a previously unknown regulatory mechanism in the body's response to eliminate pathogens, such as bacteria and viruses. The findings challenge a long-held dogma in the field of immunology and have potential implications for far-ranging topics from how vaccines should be administered to the origin of autoimmunity.

The results of the study, led by Scripps Research Professor Michael McHeyzer-Williams, were published in the December issue of the journal Nature Immunology (Volume 11, Number 12).

The new study focuses on plasma cells, which are a component of the immune system known for producing large quantities of antibodies targeted disease-fighting proteins. The new study, however, shows plasma cells also act in a negative feedback loop, the end result of which affects the function of other higher-ranking immune cells called follicular helper T cells (TFH).

"These plasma cells are not only capable of secreting highly specialized antibodies, but they are also involved in the regulation of the process that generates the mature immune response," said Nadge Pelletier, a research associate in the McHeyzer-Williams lab and first author of the new paper.

Previous to this work, scientists thought of plasma cells as simple soldiers in the fight against the body's foreign invaders and lacking in the ability to direct the course of future battles.

Protecting Our Body from Foreign Invaders

The immune system is our body's military, and like a real military it detects and eliminates invaders, pathogens such as bacteria or viruses that are responsible for illness. The immune system must also recognize the body's own "self" cells (civilians) so they are not mistaken for invaders. The immune system has an innate (non-specific) component and an adaptive (specific) component. The adapti
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Judy and J. John Goodman give $50,000 gift to Scripps Florida
2. New Scripps Florida scientist awarded pair of unconventional grants
3. Scripps Research scientists identify new mechanism regulating daily biological rhythms
4. Scripps Research team watches formation of cells protein factories for first time
5. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
6. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
7. Scripps Research study challenges conventional theory of modern drug design
8. Scripps Research scientists develop novel test that identifies river blindness
9. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
10. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
11. Scripps scientists develop test providing new pathway for identifying obesity, diabetes drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... the first cause of dementia and affects some 400,000 ... yet been found. One of the reasons for this ... which cause alterations in nerve transmissions and the loss ... Researchers from the Institute of Neuroscience at the Universitat ... in memory consolidation and were able to develop a ...
(Date:4/23/2014)... April 23, 2014 A biomedical engineer at the ... innovative technology to make blood transfusions safer. His work ... National Institutes of Health (NIH). , Blood transfusions ... of modern medicine,s absolute necessities. Without them, for instance, ... transfusions are perfect, however. There,s strong evidence that transfusions ...
(Date:4/23/2014)... used to read quickly. It involves visual searching ... and/ or sentences. Similarly to humans, biological systems ... genetic information. Genes that need to be read ... encoding message, the easier it will be to ... de Cincia (IGC, Portugal) and Centre for Molecular ...
Breaking Biology News(10 mins):Loss of memory in Alzheimer's mice models reversed through gene therapy 2UH biomedical engineer works to make blood transfusions safer 2UH biomedical engineer works to make blood transfusions safer 3Cell division speed influences gene architecture 2
... CAMBRIDGE, Mass. The evolution of human speech was far ... link it to a specific gene, says Robert Berwick, professor ... ideas about language in a session at the annual meeting ... Sunday, Feb. 17. The session is called Mind of a ...
... considerations and fears about global warming have helped revive ... cleanly and can be produced from plants. But ... corn-based ethanol: the more corn is used in ethanol ... partly accounts for the recent run-up in world food ...
... and closely linked social and ecological systems along our ... Guerry says can be addressed by a new approach ... Guerry will discuss the use of ecosystem services, ... marine resources in her AAAS presentation Ecosystem Services Provided ...
Cached Biology News:MIT: No easy answers in evolution of human language 2MIT: No easy answers in evolution of human language 3MIT professor to discuss future of biofuels 2Can Dungeness crab and eelgrass help improve management of our marine resources? 2
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
(Date:1/15/2014)... Biotechnology Company, Limited ("TaiGen") today announced that they have ... pharmaceutical company, to develop and commercialize nemonoxacin (Taigexyn ® ... Turkey and other members of ... for the treatment of bacterial infections including those caused ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
Breaking Biology Technology:Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2
... N.J., Oct. 8 Managed Health Care,Associates, Inc. ... that it plans to open the 2008 MHA ... Secretary, Health and Human Services,(2001-2005), former four-term Governor ... Independent Chairman, Deloitte,Center for Health Solutions. Marking the ...
... announced today that it has entered into a ... producer of infant,formula products including the Similac(R) Advance(R) ... and ARA supplier for all of its,infant formula ... with,Abbott having the right to terminate the arrangement ...
... patients to benefit from rapid, long-lasting symptom control with ... ... fumarate -, NAPA, Calif., Oct. 8 Dey, L.P., ... the launch of Perforomist(TM),(formoterol fumarate) Inhalation Solution, which will be ...
Cached Biology Technology:MHA Announces: Tommy Thompson to be Keynote Speaker at The MHA 5th Annual Business Summit 2Martek Signs Multi-Year Worldwide Sole Source Supply Agreement with Abbott 2Mylan Inc. Subsidiary, Dey, L.P., Announces that Perforomist(TM) (Formoterol Fumarate) Inhalation Solution is Now Available for Maintenance Treatment of COPD 2Mylan Inc. Subsidiary, Dey, L.P., Announces that Perforomist(TM) (Formoterol Fumarate) Inhalation Solution is Now Available for Maintenance Treatment of COPD 3Mylan Inc. Subsidiary, Dey, L.P., Announces that Perforomist(TM) (Formoterol Fumarate) Inhalation Solution is Now Available for Maintenance Treatment of COPD 4Mylan Inc. Subsidiary, Dey, L.P., Announces that Perforomist(TM) (Formoterol Fumarate) Inhalation Solution is Now Available for Maintenance Treatment of COPD 5Mylan Inc. Subsidiary, Dey, L.P., Announces that Perforomist(TM) (Formoterol Fumarate) Inhalation Solution is Now Available for Maintenance Treatment of COPD 6
AC input: 50-60 Hz230 V...
AC input: 50-60 Hz 115-120 V...
... reagent is formulated specifically for Alkaline Phosphatase ... levels of activity for both the enzyme ... final dilution. This product has been ... the customer a longer shelf life, resistance ...
... is a valuable tool for removing SDS ... of SDS in biological samples imparts a ... complex, inhibits enzymatic activity during digestion, and ... contaminant in mass spectrometry analyses. We ...
Biology Products: