Navigation Links
Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling
Date:9/6/2011

JUPITER, FL, September 6, 2011 In a joint study, scientists from the California and Florida campuses of The Scripps Research Institute have shown that changes in a protein's structure can change its signaling function and they have pinpointed the precise regions where those changes take place.

The new findings could help provide a much clearer picture of potential drugs that would be both effective and highly specific in their biological actions.

The study, led by Patrick Griffin of Scripps Florida and Raymond Stevens of Scripps California, was published in a recent edition of the journal Structure.

The new study focuses on the β2-adrenergic receptor, a member of the G protein-coupled receptor family. G protein-coupled receptors convert extracellular stimuli into intracellular signals through various pathways. Approximately one third of currently marketed drugs (including for diabetes and heart disease) target these receptors.

Scientists have known that when specific regions of the receptor are activated by neurotransmitters or hormones, the structural arrangement (conformation) of the receptor is changed along with its function.

"While it's accepted that these receptors adopt multiple conformations and that each conformation triggers a specific type of signaling, the molecular mechanism behind that flexibility has been something of a black box," said Griffin, who is chair of the Scripps Research Department of Molecular Therapeutics and director of the Scripps Florida Translational Research Institute. "Our findings shed significant light to it."

The study describes in structural detail the various regions of the receptor that are involved in the changes brought about by selective ligands (ligands are molecules that bind to proteins to form an active complex), which, like a rheostat, run the gamut among activating the receptor, shutting it down, and reversing its function, as well as produ
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research scientists establish new class of anti-diabetic compound
2. Scripps Research scientists produce first stem cells from endangered species
3. Scripps Research scientists help pinpoint cause of stress-related DNA damage
4. Scripps Research scientists expand knowledge of cell process involved in many diseases
5. Scripps Research scientists create vaccine against heroin high
6. Scripps Research scientists solve mystery of nerve disease genes
7. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
8. Scripps study finds plastic in 9 percent of garbage patch fishes
9. Scripps Research Institute Scientist Knighted by Italian Republic
10. Scripps Research team sheds new light on how blood clots form
11. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists pinpoint shape-shifting mechanism critical to protein signaling 
(Date:4/24/2014)... snapping turtle is the largest river turtle in North ... living almost a century. Now researchers from Florida and ... not one species but three. , Examining museum ... divisions in this ancient reptile. , Once heavily hunted ... ingredient of Campbell,s Turtle Soup in the 1960s ...
(Date:4/24/2014)... a welcome mat to bacteria seeking to invade, and scientists ... this week in the Proceedings of the National Academy ... microbe and host that researchers can exploit to protect plants. ... Arabidopsis puts out a molecular signal that invites ... army were unknowingly passing by a castle, and the sentry ...
(Date:4/23/2014)... added "playwright" to their resumes in an effort to ... of ethical issues as genomic science transitions to bedside ... sequenced. , Until now the plays of Karen ... for, and by, their peers and others in the ... With Oxford University Press, publication of the book ...
Breaking Biology News(10 mins):Two new US turtle species described 2Two new US turtle species described 3How a plant beckons the bacteria that will do it harm 2How a plant beckons the bacteria that will do it harm 3Bioethicists use theatrical narratives to bridge the gap between society and science 2Bioethicists use theatrical narratives to bridge the gap between society and science 3
... Stephen Moose has developed a corn plant with enormous potential ... silage, Moose said, due to a greater number of leaves ... energy crop. The gene known as Glossy 15 was ... waxy coating that acts like a sun screen for the ...
... for its health benefits. But now scientists have ... produce medicines for several autoimmune and inflammatory diseases, ... open access journal BMC Biotechnology . ... research organizations have participated in the study as ...
... knows, children love sweet-tasting foods. Now, new research ... indicates that this heightened liking for sweetness has a ... rate. "The relationship between sweet preference and growth ... demands increase. Children are programmed to like sweet ...
Cached Biology News:Doubling a gene in corn results in giant biomass 2Tobacco makes medicine 2Liking sweets makes sense for kids 2
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... 14, 2014 Global Record Systems, ... information technology solutions for patients, physicians, the biopharmaceutical ... announced today the signing of a three-year Research ... Drug Administration (FDA). This initiative is designed ...
(Date:1/14/2014)... During the 1600’s through the 1800’s doctors contributed ... In this time period, doctors did not know that they ... the death of vulnerable patients. In the same way, medical ... be unwittingly transmitting herpes viruses to their patients. The CBCD ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Aug. 30, 2011 Farmers in North Carolina will ... a partnership by Perdue AgriBusiness and Winston-Salem-based Technology Crops ... the crop looks identical to canola, but the oil ... applications, especially industrial uses.  Grown in trials in North ...
... Aug. 30, 2011 Amnis Corporation, a manufacturer of advanced ... acquired by EMD Millipore, the Life Science division of Merck ... and closing is expected to take place in the fourth ... disclosed. Amnis generated sales of USD 14 ...
... SANTA CLARA, Calif., Aug. 30, 2011 ProteinSimple today introduced ... Simple Western.  The Simple Western is a complete reinvention of ... protein research.  For the first time in 30 years, researchers ... analysis. The Western Blot was invented in ...
Cached Biology Technology:Perdue AgriBusiness and TCI Collaborate to Bring Profitable New Crop to North Carolina 2Perdue AgriBusiness and TCI Collaborate to Bring Profitable New Crop to North Carolina 3Perdue AgriBusiness and TCI Collaborate to Bring Profitable New Crop to North Carolina 4Amnis Acquired by EMD Millipore - Expands Growth Potential 2Amnis Acquired by EMD Millipore - Expands Growth Potential 3ProteinSimple Reinvents the Western Blot 2
... Mouse C2C12 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
... Sample Buffer is a convenient, ... experimental samples and Perfect RNA ... needs no dilution and is ... gels. Simply mix equal volumes ...
... cells were cultured in DMEM and harvested at ... to keep the antigens in their native forms, ... are arrayed on a 12-well (5 mm) adhesive ... to enhance cellular attachment and to minimize background ...
... CopyControl™ vector can be induced prior to ... provide the stability of single-copy BACs with ... other cloning vectors. The kits provide the ... insert size screening system) necessary to create ...
Biology Products: