Navigation Links
Scripps Research scientists observe human neurodegenerative disorder in fruit flies
Date:6/24/2009

ponding single-stranded piece of messenger RNA. Then an enzyme called the ribosome uses the mRNA as a template to make a protein by reading out its genetic sequence and then translating it into a string of amino acids. That's where the tRNA synthetases are needed.

When building new proteins, ribosomes rely on a set of molecules called transfer RNAs (tRNAs) to supply them with the amino acids they need to construct the proteins. The tRNA synthetases are needed to attach amino acids to the tRNAs.

Sound complicated? It is. But the action of tRNA synthetases is also so essential that every creature on the planet has these molecules, which probably evolved very early on as life first emerged on Earth.

"These proteins are among the first to appear in the planet," says Schimmel, who led the current research effort. "All cells need them to grow, divide, and survive."

When mutations in tyrosyl-tRNA synthetase were linked to Charcot-Marie-Tooth disease a few years ago, scientists debated whether problems arose because the mutations interfered with tRNA synthetase's normal function, helping to express genes into proteins, or whether they arose because the mutations interfered with some other unknown function.

Schimmel had been studying this type of molecule for many years and had already discovered novel functions that had evolved over time in some tRNA synthetases, including this one. He reckoned that, if one could first show that a CMT-causing mutant synthetase was active for protein synthesis, then recreating the same disease in another organism (by putting the same mutations in the other organism's analogous gene) would demonstrate that a novel function was at play.

This is exactly what he and his scientific collaborators did. After showing that the disease was not caused by a defect in the synthetase's activity for protein synthesis, the researchers created the same mutations to the equivalent protein in the fruit fl
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps studies offer new picture of Lake Tahoes earthquake potential
2. Scripps scientists help decode mysterious green glow of the sea
3. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
4. Scripps research scientists watch as individual alpha-synuclein proteins change shape
5. Scripps research team identifies key molecules that inhibit viral production
6. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
7. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
8. Scripps scientists develop first examples of RNA that replicates itself indefinitely
9. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
10. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
11. Scripps research team defines new painkilling chemical pathway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Ongoing deforestation and fragmentation of forests in the ... remnant forests, contributing to rapid and widespread forest ... of researchers., The findings show that forests in ... severe droughts coupled with forest fires lead to ... said Jennifer Balch, assistant professor of geography, Penn ...
(Date:4/17/2014)... conditions such as heart disease, epilepsy and pain, making ... there is still much scientists do not know about ... insight into the structure of sodium channels and, specifically, ... are responsible for ,fine-tuning, the activity of the channel. ... of the Journal of Biological Chemistry . , ...
(Date:4/17/2014)... reporting in the Cell Press journal Current Biology ... with rather novel sex lives. The Brazilian insects, which ... Neotrogla , are the first example of an ... has been identified in several different animals, Neotrogla ... organ is also reversed," says Kazunori Yoshizawa from Hokkaido ...
Breaking Biology News(10 mins):Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Structure of sodium channels different than previously believed 2In sex-reversed cave insects, females have the penises 2
... research group of Dr. Frdric Charron, a researcher at the ... discovery which could help treat spinal cord injuries and neurodegenerative ... issue of the prestigious scientific journal Neuron . Patricia ... the IRCM, are listed as co-authors. The brain is ...
... of the most successful scientists within stem cell research, ... for biotech and pharmaceuticals, BIO 2009 in Atlanta, USA. ... Karolinska Institutet, SwedenBIO and Invest in Sweden Agency. ... one of the most exciting areas in science, and ...
... years ago, it was discovered that bacteria known as ... antibiotics have become the primary therapy used to combat the ... of the world population and is also a primary cause ... resistant to antibiotics. Now a study led by ...
Cached Biology News:Identification of a key molecular pathway required for brain neural circuit formation 2Glutamine supplements show promise in treating stomach ulcers 2Glutamine supplements show promise in treating stomach ulcers 3
(Date:1/15/2014)... , Jan. 15, 2014 TaiGen Biotechnology Company, ... exclusive agreement with R-Pharm, a leading Russian pharmaceutical company, ... the Russian Federation , ... Independent States (CIS). Nemonoxacin is a novel antibiotic for the ...
(Date:1/14/2014)... DC (PRWEB) January 14, 2014 Carahsoft ... for Thursday, January 23, 2014 at 2pm EST (11am ... Knowledge.” The topic focuses on how technology can turn ... critical decisions for government agencies. The online webinar will ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua is an ... products to serve the wound care market. , Free ... Alliqua was restructured with a seasoned management team and ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... resonance energy transfer (FRET) between GFP , fusions in lysates ... Varian , Cary Eclipse , ... Daren J. Fyfe, Ph.D* , ... Clayton campus Victoria 3800, Australia , ...
... Overview , ... of the separation and purification of a number of biological molecules. ... protein A, or a protein may be purified on the basis ... these purifications take place in a chromatographic column with a relatively ...
... Purpose , ... and quantified more effectively and efficiently using LC/MS/MS. These agricultural compounds ... Overview , ... worldwide are placing great importance on the identification and quantitation of ...
Cached Biology Technology: Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 2 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 3 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 4Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 2Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 3Identification of Insecticides and Herbicides by LC/MS/MS Using the API 2000 LC/MS/MS System 2
Non-Protein Peroxidase Stabilizer , 1 L...
... Lysate contains the cellular components necessary for ... elongation and termination factors) but has not ... is used primarily for the isolation of ... of endogenous globin mRNA. Untreated Lysate is ...
... All MagCellect Ferrofluid products ... conjunction with R&D Systems MagCellect ... capacities, this neodymium iron boron ... 12 x 75 mm test ...
... ScriptCap™ 2'-O-Methyltransferase converts Cap 0 (or Cap ... Cap 1 structure has been shown to ... to 50%. This improvement is seen in ... m7G Capping System as well as those ...
Biology Products: