Navigation Links
Scripps Research scientists identify new mechanism regulating daily biological rhythms
Date:11/11/2010

JUPITER, FL, November 9, 2010 For Immediate Release Scientists from the Florida campus of The Scripps Research Institute have identified for the first time a novel mechanism that regulates circadian rhythm, the master clock that controls the body's natural 24-hour physiological cycle. These new findings could provide a new target not only for jet lag, shift work, and sleep disturbances, but also for disorders that result from circadian rhythm disruption, including diabetes and obesity as well as some types of cancer.

The study is published in the November 12, 2010 edition (Volume 285, Number 45) of the Journal of Biological Chemistry.

"It's well known that the nuclear receptors RORα and REV-ERBα regulate expression of the gene BMAL1, which is vital to virtually every aspect of human physiology and a core component of the circadian clock," said Tom Burris, a professor in the Department of Molecular Therapeutics at Scripps Florida who led the study. "BMAL1 functions as an obligate heterodimer (only working as a dimer with a partner) with either CLOCK or NPAS2 so it was unclear how RORa and REV-ERBa could control this complex. In this study, we show that both partners are targets. As we understand more about the relationship between these receptors and their gene targets, we can consider the possibility of modulating the body's core clock, especially as we continue to develop synthetic ligands targeting these two nuclear receptors."

Circadian rhythms are conserved across a wide variety of organisms, from Drosophila (fruit flies) to humans. In mammals, these rhythms respond to light signals and are controlled by the "master clock" in the brain. In the periphery, semi-autonomous clocks can respond to signals from the brain and from other cues including nutrient status. Disorders linked to dysfunctional circadian rhythms can be severe and potentially deadly, Burris said.

"When you're dealing with circad
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team watches formation of cells protein factories for first time
2. Landenberger Foundation awards grant to Scripps Florida scientist to study HIV
3. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
4. Scripps Research study challenges conventional theory of modern drug design
5. Scripps Research scientists develop novel test that identifies river blindness
6. Scripps researchers, UCSD chemists to create center devoted to chemistrys influence on climate
7. Scripps Research scientists win $65 million in new grants to reveal form and function of proteins
8. Scripps scientists develop test providing new pathway for identifying obesity, diabetes drugs
9. Scripps research team wins $5.1 million to develop DNA sequencing technology
10. Team led by Scripps Research scientist identifies new gene for memory
11. Seafood stewardship questionable: UBC-Scripps experts
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... YORK , April 14, 2015  HYPR ... IDentity Online (FIDO ® ) Alliance tm , ... specifications. FIDO members commit to share technology and ... methods that are interoperable, more secure and private, ... enable biometric identity verification that protects sensitive user ...
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
(Date:4/8/2015)... , April 8, 2015  Infinisource, a leading ... services, and Morpho, a leading supplier of biometric ... produce the market,s most advanced biometrically-enabled time clock, ... NXG time clock is setting a bold, new ... data for the small and mid-size employer. When ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... Researchers from Murdoch Childrens Research Institute and the University ... test for peanut allergy. It is hoped the ... standard approaches and minimise over-diagnosis of peanut allergy in ... challenge is the standard for diagnosing peanut allergy, and ...
... MD (March 20, 2012)Since the explosion on the BP Deepwater ... 20, 2010, scientists have been working to understand the impact ... crude oil gushed into the water at a rate of ... on July 15, 2010. A new study confirms that oil ...
... by overly gregarious yet anxious behavior is rooted in abnormal ... center of the brain, say scientists at the National Institutes ... to pinpoint the suspect brain area in people with Williams ... Matching the scans to scores on a personality rating scale ...
Cached Biology News:Test to improve peanut allergy diagnosis 2Study confirms oil from Deepwater Horizon disaster entered food chain in the Gulf of Mexico 2Friendly to a fault, yet tense: Personality traits traced in brain 2Friendly to a fault, yet tense: Personality traits traced in brain 3
(Date:5/26/2015)... 26. mája 2015 Kevin Xu ... rodiny prezidentom Barackovi Obamovi a Billovi Clintonovi za ... stratou Dr. Rongxiang Xu , otca Kevina. ... Dr. Xu bol pionier, inovátor, humanitárny ... odhodlanie v oblasti vedy a príkladné vedenie svojej ...
(Date:5/26/2015)... -- Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ... on the development of oral drug delivery systems, announced ... the company,s Phase IIb trial of ORMD-0801, its oral ... (FDA). The submission was made under the company,s existing ... IIb study of ORMD-0801 for type 2 diabetics is ...
(Date:5/26/2015)... NEW YORK , May 26, 2015 ... NVGN ), announced today that it will present at the ... New York City at the Grand Hyatt ... Kelly , Novogen Chairman and CEO, is scheduled to begin at ... To access the webcast, go to http://wsw.com/webcast/marcum3/nvgn . ...
(Date:5/25/2015)... a science-driven healthcare company seeking to solve some of ... that Dame Marjorie Scardino , Chairman of the ... appointed to PureTech,s Board of Directors in the role ... Joi Ito , MIT Media Lab,s Director, has ... PureTech,s outgoing Chairman and co-founder, former Executive Vice President ...
Breaking Biology Technology:Dr. Rongxiang Xu, O legende 2Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 2Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 3Novogen to Present at the 2015 Marcum Microcap Conference 2Novogen to Present at the 2015 Marcum Microcap Conference 3Novogen to Present at the 2015 Marcum Microcap Conference 4PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 2PureTech Adds Dame Marjorie Scardino to Board of Directors, Names Joi Ito as Chairman of the Board and Expands Management Team 3
... 11 Trubion Pharmaceuticals,Inc. (Nasdaq: TRBN ), today ... Office (EPO) has revoked Genentech and Biogen Idec,s,European Patent ... the use of an anti-CD20 antibody for the treatment ... an opposition,proceeding brought by Trubion and several other parties., ...
... Indications and Products Offset Patent Expirations, SAN ... drug,treatment of major neuropathic pain (NP) conditions is ... Pain, a report released today by,WWMR, Inc. Growth ... largely by the,successful launch of Lyrica (pregabalin) for ...
... by US ... Department of Labor, SAN FRANCISCO, ... for the life sciences industry,announced today the incorporation of useful career ... Web site created,by the San Diego Workforce Partnership. The new content ...
Cached Biology Technology:Trubion Pharmaceuticals Wins Patent Opposition - Genentech / Biogen Idec European Patent Revoked 2Trubion Pharmaceuticals Wins Patent Opposition - Genentech / Biogen Idec European Patent Revoked 3US Neuropathic Pain Market Value Doubles to $5 Billion by 2018 2US Neuropathic Pain Market Value Doubles to $5 Billion by 2018 3BioSpace Launches Life Science Career Content and Resources from the Biotech Work Portal 2BioSpace Launches Life Science Career Content and Resources from the Biotech Work Portal 3
... The TUNEL-based assay kit provides complete ... cells for convenient detection of DNA ... sections. The incorporation of BrdU in ... biotinylated or digoxigenylated methods. Results can ...
... LAS-3000 imaging system combines new CCD ... interface, providing significantly improved system sensitivity ... The system is especially dedicated to ... system for Western blotting applications.,Fuiji's LAS-3000 ...
... The Fujifilm Life Science LAS-3000mini is ... dedicated to chemiluminescence applications, and the ... applications., Fuiji 's LAS-3000 provides significantly ... digitization. , Glowell calibration standards validate ...
... assay kit provides complete components including positive ... of DNA fragmentation in cultured cells and ... labeling of apoptotic cells. Internucleosomal ... in mammalian cells. MBLs ApoDIRECT In Situ ...
Biology Products: