Navigation Links
Scripps Research scientists identify key interaction in hepatitis C virus
Date:12/28/2010

JUPITER, FL, December 28, 2010 Scientists from the Florida campus of The Scripps Research Institute have identified a molecular interaction between a structural hepatitis C virus protein (HCV) and a protein critical to viral replication. This new finding strongly suggests a novel method of inhibiting the production of the virus and a potential new therapeutic target for hepatitis C drug development.

The study was published in the January 2010 issue (Volume 92, Part 1) of the Journal of General Virology.

These new data underline the essential role of the viral protein known as "core" as a primary organizer of the infectious HCV particle assembly and support a new molecular understanding of the formation of the viral particle itself.

"While our finding that the HCV core interacts with the non-structural helicase protein was not totally unexpected, this had not really been confirmed until this study," said Scripps Florida Professor Donny Strosberg, who led the study. "But the most exciting part is that small molecule inhibitors of dimerization [the joining of two identical subunits] of core actually inhibit interaction between core and helicase, thus possibly preventing production of an infectious viral particle."

A Viral Plague

Hepatitis C virus infects between 130 and 170 million people worldwide and is the cause of an epidemic of liver cirrhosis and cancer. Because current HCV treatments are only partially effective, a number of alternative molecular mechanisms are actively being pursued as possible drug targets.

One of the critical problems of finding inhibitors for the hepatitis C virus is that it mutates at such prodigious rates. An RNA virus such as hepatitis C can mutate at a rate estimated as high as one million times that of DNA viruses such as the herpes virus.

With this in mind, Strosberg has been examining the core protein, the most conserved protein among all HCV genotype
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/8/2015)...  Infinisource, a leading provider of SaaS-based Human Capital ... leading supplier of biometric identification and security solutions, ... advanced biometrically-enabled time clock, the companies announced today. ... setting a bold, new standard for the collection ... and mid-size employer. When connected to the iSolved ...
(Date:4/2/2015)... According to preliminary estimates Fingerprint ... higher than 125 MSEK. This exceeds the guidance provided ... revenues for Q1 2015 would be in line with ... 2014. The operating result for the first quarter is ... report will as previously communicated be published on May ...
(Date:3/31/2015)... 2015  Elephant Talk Communications Corp. (NYSE MKT: ETAK) ... Software Defined Network Architecture (ET Software DNA® 2.0) platforms ... approximately $20.4 million for the year ended December 31, ... the year ended December 31, 2013. ... completed its multi-year transition away from its legacy landline ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Revises Revenues for Q1 2015 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6
... Measuring Energetics and Behaviour Using Accelerometry in Cane Toads ... Bufo marinus were introduced to Australia as a ... and damage new habitats they enter. Predictive models that can ... ground distribution could help to maximise control efficiency but to ...
... Cell biologist Daniel Gottschling, Ph.D., a member of the ... has been elected to membership in the American Academy ... nation,s oldest and most prestigious honorary societies and independent ... the molecular underpinnings of life clues that he ...
... NY, April 21, 2010 In recognition of Earth Day,s ... ) will provide complimentary online access to its journals ... Journal of Record; Environmental Justice; and Ecopsychology ... information about sustainability initiatives, the relationship between mankind and ...
Cached Biology News:Cane toad accelerometry and more 2Cane toad accelerometry and more 3Cane toad accelerometry and more 4Cane toad accelerometry and more 5Cane toad accelerometry and more 6Cell biologist Daniel Gottschling elected to American Academy of Arts & Sciences 2Expert commentary on Earth Day's 40th anniversary 2
(Date:5/5/2015)... May 5, 2015  Blueprint Medicines (NASDAQ: ... initial public offering of 9,367,708 shares of common ... per share, including shares of common stock issued ... their option to purchase additional shares. The gross ... Medicines were approximately $168.6 million, before underwriting discounts and ...
(Date:5/5/2015)... , May 5, 2015 Roka Bioscience, Inc. ... providing advanced testing solutions for the detection of foodborne pathogens, ... at the Bank of America Merrill Lynch 2015 Health Care ... be held at Encore at the Wynn, Las ... of the presentation will be available through the investor relations ...
(Date:5/5/2015)... Poway, CA (PRWEB) May 05, 2015 ... Pall Life Science Animal Health, Jeffrey Schaffer, DVM, ... , “With over 15 years of experience in ... be a great addition to our veterinarian lead ... Commercial Officer, explains. “Dr. Schaffer will be responsible ...
(Date:5/5/2015)... DUBLIN , May 05, 2015 /PRNewswire/ ... ) has announced the addition of the ... report to their offering. Macromolecules ... acids undergo separation or are broken into ... biotechnological products. This separation requires various advanced ...
Breaking Biology Technology:Blueprint Medicines Announces Closing of Initial Public Offering 2Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2
... Biosciences,Incorporated (Nasdaq: KOSN ) today announced that ... as Chief Executive Officer, effectively immediately.,Ms. Kim joined ... and Chief,Business Officer, and was appointed President in ... of the Board, commented: "We,believe that Helen possesses ...
... and,the president of one of the area,s major ... Committee as winners of the region,s third,bioscience award ... Region Bioscience Awards are:, -- Best New ... CEO, CSA,Medical, Inc. Askew,s very young Baltimore-based company ...
... Study Successfully Hit Primary End Point of ... Toward Superiority over the Market Leader, ... (NASDAQ: ANPI , TSX: ANP), a ... today that the clinical data from its ...
Cached Biology Technology:Kosan's Board of Directors Appoints Helen S. Kim as Chief Executive Officer 2Kosan's Board of Directors Appoints Helen S. Kim as Chief Executive Officer 3Kosan's Board of Directors Appoints Helen S. Kim as Chief Executive Officer 4Three CEOs and University President Named Winners of Greater Baltimore Committee's 2008 Baltimore Region Bioscience Awards 2960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 2960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 3960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 4960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 5960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 6960-Patient Study Demonstrates Zero Blood Stream Infection In Patients Treated With Angiotech's Novel 5-FU Central Venous Catheter 7
RABBIT ANTI ISOCITRATE DEHYDROGENASE...
Recombinant Equine TNF-alpha/TNFSF1A, CF...
Recombinant Feline IL-2, CF...
... Fernandez and G. Butcher (1998). • The ... much research in the immunology area. There ... MHC proteins and in their function as ... faced with the prospect of tackling biochemical ...
Biology Products: