Navigation Links
Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug
Date:2/3/2010

LA JOLLA, CA February 3, 2010 For Immediate Release A team of scientists at The Scripps Research Institute has identified two compounds that act on novel binding sites for an enzyme used by the human immunodeficiency virus (HIV), the virus that causes AIDS. The discovery lays the foundation for the development of a new class of anti-HIV drugs to enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus.

The research will appear as the cover story of the March issue of the journal Chemical Biology & Drug Design.

The anti-HIV compounds identified in the new study bind to HIV proteasean enzyme essential to the lifecycle of the virus. Drugs that block this viral enzyme are called "protease inhibitors" and currently make up an important part of the successful AIDS drug cocktail known as highly active anti-retroviral therapy (HAART).

Compared with the nine U.S. Food and Drug Administration (FDA)-approved drugs that target HIV protease, however, the two new compounds, which are small chemical units or "fragments," bind with two novel parts of the molecule. This could make future drugs incorporating the fragments' novel structural elements a useful complement to existing treatments.

"The study's results open the door to a whole new approach to drug design against HIV protease," said Scripps Research Associate Professor C. David Stout, senior author of the study. "The fragments bound at not one, but two, different crevices in protease outside the active site. This is an important proof-of-concept that the protease molecule has two non-active site binding pockets ('allosteric sites') which can now be exploited as a powerful new strategy to combat drug-resistance in HIV."

Research Associate Alex L. Perryman, first author of the paper and member of Professor Arthur Olson's laboratory at Scripps Research, added, "The experiments validate my hypothe
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Scripps scientists discover fluorescence in key marine creature
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
4. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
5. Scripps expedition provides new baseline for coral reef conservation
6. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
7. Fishing throws targeted species off balance, Scripps study shows
8. Scripps Oceanography Research pegs ID of red tide killer
9. Scripps Research Institute awarded patent for remarkable chemical technology
10. Scripps research scientists reveal key structure from ebola virus
11. Scripps study sets high economic value on threatened Mexican mangroves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 23, 2014 Research and Markets  has ... Forecast and Opportunities, 2019" report to their offering. ... for enhancing security and protection in private as well ... The country,s government is focusing on using biometric systems ... other national IDs that are of crucial importance to ...
(Date:9/23/2014)... Florida , September 23, 2014 ... innovative companies in tech sector position for significant investor attention ... & services.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... BABA ), Mobileye N.V. (NYSE: MBLY ), ... Ltd. (NASDAQ: RWLK) NXT-ID, Inc. (NASDAQ: ...
(Date:9/23/2014)... including humans, have parasitic DNA fragments called "jumping genes" ... in the process. And that phenomenon can result in ... University of Rochester now report that the "jumping genes" ... a multi-function protein stops keeping them in check in ... a study published today in Nature Communications , ...
Breaking Biology News(10 mins):India Biometrics Market Forecast and Opportunities, 2019 2India Biometrics Market Forecast and Opportunities, 2019 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 2Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 3Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 4Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 5Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 6Latest Blockbuster IPOs and Up Listings for Global Tech Stocks Attracting Major Attention as Traders Focus on Key Economic Data Due this Week 7A multi-function protein is key to stopping genomic parasites from 'jumping' 2
... study from the University of Rochester finds that there is ... it language capabilities above and beyond those of any other ... brain, each designed to accomplish different primitive tasks, in order ... of grammar used in forming a given sentence, the brain ...
... have developed a way to enhance how brain tumors appear ... for surgeons to identify and remove. Scientists at Ohio ... may one day be injected into the blood of patients ... In the journal Nanotechnology, researchers reported that ...
... An international research consortium including scientists from The ... (UTHealth) has identified a new genetic link to ... thorough understanding of the genetic nature of the ... Systemic scleroderma is a profoundly disabling autoimmune disease ...
Cached Biology News:Sign language study shows multiple brain regions wired for language 2Sign language study shows multiple brain regions wired for language 3Tiny particles may help surgeons by marking brain tumors 2Study reveals new genetic link to scleroderma 2Study reveals new genetic link to scleroderma 3
(Date:9/23/2014)... About Bioactive Material Bioactive ... are increasingly becoming popular due to their ability ... having a negative impact on the human health. ... tissue repair materials in surgical procedures. Bioactive materials ... glass-ceramics, and composites. The major end-users of bioactive ...
(Date:9/23/2014)... 23, 2014 Kamal Rashid , ... Education and Training Center (BETC) and research professor of ... BioTalk 2014 , an international two-day event focused on ... by Global Summits, the event will bring together leaders ... cells to develop and produce human therapeutics. “The growth ...
(Date:9/23/2014)... 2014 This is a professional ... the Phenolic Resin industry in Global and China.The ... including definitions, applications and industry chain structure. Global ... provided with a focus on history, developments, trends ... between the international and Chinese situation is also ...
(Date:9/23/2014)... Erlab , the expert in ... and Burdinola, supplier of laboratory furniture solutions, announce a ... hood. , By integrating Erlab’s GreenFumeHood ... now offer an innovative solution utilizing the patented technology ... best-in-class detection technology, and communication for security and monitoring ...
Breaking Biology Technology:Global Bioactive Material Market 2014-2018 2Worcester Polytechnic Institute's Biomanufacturing Expertise to be Featured in Berlin 2Worcester Polytechnic Institute's Biomanufacturing Expertise to be Featured in Berlin 3Phenolic Resin Industry (International, China) Development Policy and Plan Now Available at ReportsnReports.com 2Erlab Partners with Burdinola to Deliver an Innovative Filtered Fume Hood 2
... India, September 9 , ... Consulting Solutions for Health Care , ... the launch of its first business vertical-focused learning,solutions for ... initiative with the appointment of Candida Chandorkar as Vice,President ...
... WILMINGTON, N.C., Sept. 9 Jim Robison has been named ... several new Sanford Rose Associates executive search offices opening in ... Environmental Systems and CFO of House of Raeford Farms. With ... growing agribusiness, food processing, and distribution companies, Robison is a ...
... ... designed to find the genetic cause of Chiari-like Malformation and syringomyelia in dogs. Chiari-like malformation ... out of the skull and crowds the spinal cord, putting pressure on both the brain ... ...
Cached Biology Technology:Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 2Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 3Tata Interactive Systems Initiates Vertical-Focused Learning Solutions for Health Care, Pharmaceutical, and Biotechnology 4Sanford Rose Associates Opens Wilmington, N.C. Office 2DNA Genotek's Oragene●ANIMAL DNA Collection Kit Plays Key Role in Determining the Genetic Cause of Chiari Malformation in Dogs 2DNA Genotek's Oragene●ANIMAL DNA Collection Kit Plays Key Role in Determining the Genetic Cause of Chiari Malformation in Dogs 3
... BR4i refrigerated multifunction centrifuges are equally capable of ... low sound level with a large range of ... rotor exchange system without tools ensures that the ... Instant rotor exchange (5 sec.) ...
... ,Each upright model provides fast pull-down, rapid ... for refrigerated blood. The BBR25 and BBR55 ... complete blood storage monitoring. Models BBR6, BBR11, ... HemaPro 101 alarm/monitor. All of these models ...
Sterile, individually wrapped, 4mm Cuvettes...
... form of Tobacco Etch Virus (TEV) protease ... significantly more stable than native TEV protease, ... recognizes a seven amino acid (Glu-Asn-Leu-Tyr-Phe-Gln-Gly, cleaving ... for removing affinity tags from fusion proteins ...
Biology Products: