Navigation Links
Scripps Research scientists find new way to attack cancerous cells
Date:6/7/2010

LA JOLLA, CA June 7, 2010 Scripps Research Institute scientists have discovered a new way to target and destroy a type of cancerous cell. The findings may lead to the development of new therapies to treat lymphomas, leukemias, and related cancers.

The study, which appears in the June 10, 2010 edition of the journal Blood, showed in animal models the new technique was successful in drastically reducing B cell lymphoma, a cancer of immune molecules called B cells.

"[The method] worked immediately," said Scripps Research Professor James Paulson, who led the research. "We are very interested in moving this technology forward to see if it would be applicable to treatment of humans and to investigate other applications for this kind of targeting."

A Sweet Spot

In his research program at Scripps Research, Paulson has studied glycoproteins, which are proteins decorated with sugars, for many years. While these molecules have traditionally proven challenging to understand, limiting their pharmaceutical applications, Paulson has pioneered new techniques to study and manipulate these enigmatic molecules.

In the new research, Paulson and his colleagues applied some of the lab's insights to a problem with great medical relevancefinding a new way to target and destroy cancer cells.

Specifically, in the new study the team set out to attack B cell lymphoma (which includes Hodgkin lymphoma and non-Hodgkin lymphoma), a type of cancer diagnosed most frequently in older individuals and those with compromised immune systems. Each year approximately 70,000 people are diagnosed with B cell lymphomas in the United States alone, according to the American Cancer Society. While the drug rituximab is often effective at treating the disease, each year 22,000 patients still die from B cell malignancies.

Normally, B cells provide an important immune function circulating throughout the bloodstream to help in the a
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps scientists discover fluorescence in key marine creature
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
4. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
5. Scripps expedition provides new baseline for coral reef conservation
6. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
7. Fishing throws targeted species off balance, Scripps study shows
8. Scripps Oceanography Research pegs ID of red tide killer
9. Scripps Research Institute awarded patent for remarkable chemical technology
10. Scripps research scientists reveal key structure from ebola virus
11. Scripps study sets high economic value on threatened Mexican mangroves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , January 22, 2015 , ... year  The European Patent Office to present a video ... British nominations to be featured: Christofer Toumazou and ... former finalists and winners of the Award   Starting ...
(Date:1/22/2015)... , Jan. 22, 2015   EyeLock, Inc. , a ... has appointed Steve Gerber to the new role ... be responsible for leading development of mobile platforms and wearable ... of success and innovation in the semiconductor industry to his ...
(Date:12/24/2014)...  Since its launch in December 2014, the 1U™ ... of trying to remember their usernames and passwords through replacing ... smartphones. To assist people who have struggled to remember usernames ... 1U and focuses on redefining identity, announced today that it ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... San Diego State University researchers will lead a study ... The Guizhou snub-nosed monkey, often called the golden monkey. ... the National Science Foundation, student researchers from SDSU,s departments ... month to the Fanjingshan National Nature Reserve, home to ...
... efficient cars, buildings and domestic appliances to address climate change ... Research at the University of East Anglia. A report ... as much effort is being spent on developing energy supply technologies ... improving the efficiency with which energy is used. The ...
... Oct. 25, 2012 /PRNewswire-iReach/ -- New research shows that ... Maine have demonstrated improvements in health behaviors that persisted ... and rising health care costs continue to challenge employers, ... to reduce health risks and improve health behaviors. ...
Cached Biology News:SDSU researchers to study China's national treasure 2Efforts to mitigate climate change must target energy efficiency 2Efforts to mitigate climate change must target energy efficiency 3New Study Shows That Improvements in Employee Health Behaviors Persist Over Two Years 2
(Date:1/22/2015)... MA (PRWEB) January 22, 2015 zFlo ... is pleased to announce an exciting product from a new ... motion analysis solutions over the past 15 years, with offerings ... Most recently, their 3D IMU system (inertial measurement unit), iSen, ...
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... GenoSpace , a precision medicine software company that has developed ... of genomic, imaging and other biomedical data in research and ... , CEO of Aspera, an IBM Company, to its board ... "We are pleased to welcome Michelle ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3
... /PRNewswire/ - Respironics, Inc. (Nasdaq:,RESP) today announced that ... Apollo Light Systems, Inc., a 20-year-old, privately held ... for melatonin suppression and,circadian rhythm sleep disorders. Operating ... in American Fork, Utah and has annual revenues ...
... NKTR ) announced that Howard W. Robin, president ... upcoming BIO,InvestorForum at The Palace Hotel in San Francisco, ... Time. The presentation and Q&A session will be ... on the Investor Relations, Events,Calendar section of the Nektar ...
... from the Palace Hotel in San Francisco on Wednesday, October ... ... SAN DIEGO, Oct. 2 Favrille, Inc. (Nasdaq:,FVRL), a biopharmaceutical ... that Tamara,Seymour, Chief Financial Officer, will present at the Biotechnology,Industry Organization ...
Cached Biology Technology:Respironics Acquires Apollo Light Systems, Inc., Expands into Circadian Rhythm Device-Based Therapy Market 2Respironics Acquires Apollo Light Systems, Inc., Expands into Circadian Rhythm Device-Based Therapy Market 3
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
... ES1301 mutS are mismatch repair minus strains ... prevents repair of the newly synthesized unmethylated ... and making them helpful in such systems ... Mutagenesis Systems. Both ES1301 and BMH 71-18 ...
propidium iodide *1.0 mg/mL solution in water*...
Applications: (+) Immunocytochemistry and immunohistochemistry...
Biology Products: