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Scripps Research scientists find 'dual switch' regulates fat formation
Date:4/8/2011

s put under selling restrictions in the United States and withdrawn form the market in Europe due to increased risk of cardiovascular events. It is thought that the side effects of thiazolidinediones are due to activation of PPARγ in tissues other than fat.

To test whether TLE3 might provide an alternative target for diabetes drugs, Saez and Tontonoz engineered mice that produce higher-than-normal amounts of human TLE3 in adipose tissue and then fed the mice a high-fat diet. Normally this type of diet produces resistance to insulin and changes in glucose regulation, both risk factors for diabetes. But the engineered mice were more insulin-sensitive and had better glucose metabolism than regular mice fed the high-fat diet.

"These are the same results you would get if you stimulate PPARγ," said Saez. "So in theory you could enhance TLE3 activity to improve adipose tissue function and ameliorate the symptoms of diabetes."


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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