Navigation Links
Scripps Research scientists expand knowledge of cell process involved in many diseases
Date:8/16/2011

JUPITER, FL, August 16, 2001 As part of a joint research effort with the University of Michigan, scientists from the Florida campus of The Scripps Research Institute have for the first time defined the structure of one of the cell's most basic engines, which is required for cell growth, as it assembles from its components.

The study reveals a series of redundant mechanisms that assure production of these critical structures while avoiding any missteps that could lead to their destruction or to the production of incorrect cellular building blocks. These findings throw new light on a process that is integrally involved in a number of disease states, including cancer and Alzheimer's disease.

The study, published on August 11, 2011, in the advance online edition of the prestigious journal Science, reveals the structure of an assembly intermediate of the small ribosomal subunit.

Ribosomes, which are large macromolecular machines required for cell growth in all organisms, catalyze the production of proteins in all cells. They read the genetic code carried by messenger RNA, and then catalyze or translate that code into proteins within cells, assembling them from amino acids.

Understanding the process of ribosome assemblywhich involves almost 200 essential proteins known as "assembly factors" in addition to the four RNA molecules and 78 ribosomal proteins that are part of the mature ribosomeis a potentially fruitful area of research because of the importance of ribosome assembly for cell growth. The link between defects in ribosome assembly and cancer clearly points to this pathway as a new target for anti-cancer drugs.

In the current study, the scientists used cryo-electron microscopy (where samples are studied at temperatures of � C) to image the 40S ribosome structure.

"This is the best-defined ribosomal assembly intermediate we have ever had with true structural information on the location
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research scientists create vaccine against heroin high
2. Scripps Research scientists solve mystery of nerve disease genes
3. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
4. Scripps study finds plastic in 9 percent of garbage patch fishes
5. Scripps Research Institute Scientist Knighted by Italian Republic
6. Scripps Research team sheds new light on how blood clots form
7. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
8. Scripps Research scientist wins $1.9 million grant to study malaria
9. Scripps Research scientists find way to block stress-related cell death
10. Scripps Research scientists find key mechanism in transition to alcohol dependence
11. Scripps Research scientists create new genetic model of premature aging diseases
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists expand knowledge of cell process involved in many diseases
(Date:4/14/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces that its ... New York Design Awards under the category  ,Product Design ... Design Awards are part of a global multi-disciplinary awards ... from the marketplace, industry and judging panel. Winners will ...
(Date:4/8/2015)... CHARLOTTE, N.C. , April 8, 2015 /PRNewswire/ ... technology solutions and services, and Morpho, a leading ... in partnership to produce the market,s most advanced ... Infinisource,s iSolved NXG time clock is setting ... attendance and labor data for the small and ...
(Date:4/2/2015)... , April 2, 2015 Fingerprint ... fingerprint sensor FPC1025 from the distributor World Peace Industrial ... during Q2 2015 although the major part of the ... will be used by smartphone manufacturers in ... is included in the communicated revenue guidance of + ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... throwing unwanted fish overboard from commercial boats could put one ... say researchers at the University of Leeds. , New research ... which gannets rely on unwanted fish and offal thrown from ... "The North Sea has undergone massive environmental changes over the ...
... Scientists at the Lombardi Comprehensive Cancer Center at Georgetown University ... to tease apart in the most comprehensive way ever ... cells in cancer development and treatment. This protein determines which ... and how she will fare during her treatment. The researchers, ...
... NEW YORK, March 22, 2010 The Juvenile ... for diabetes research worldwide, said today that it will ... Organization, and The Hebrew University of Jerusalem on drugs ... type 1 diabetes. The program, under the ...
Cached Biology News:Fishing discard ban could damage sea bird success, scientists warn 2Lombardi receives $7.5 million grant for Breast Cancer Center for Cancer Systems Biology 2Lombardi receives $7.5 million grant for Breast Cancer Center for Cancer Systems Biology 3JDRF, Pfizer, Hadassah Medical and the Hebrew University announce collaboration 2
(Date:4/24/2015)... San Diego, CA (PRWEB) April 24, 2015 ... San Diego and other San Diego area universities, including ... April 28 to judges from prominent local, national and ... seed funding in the 5th Annual Social Innovation ... finalists have proposed unique social venture ideas addressing a ...
(Date:4/24/2015)... , April 24, 2015 /PRNewswire/ - BioAmber Inc. ... Bayer MaterialScience as the supplier of bio-succinic acid ... bio-based polyurethanes for textile applications that Bayer MaterialScience ... has launched IMPRANIL ® eco, a series ... that reaches as high as 65%.  IMPRANIL ® ...
(Date:4/24/2015)... , April 24 , 2015 PAREXEL ... biopharmaceutical services provider, today announced that Partnerships in Clinical ... Product Management, the 2015 Clinical Innovator of the Year.  ... development team for the Company,s Perceptive MyTrials ® ... award Thursday night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... Mount Dora, Florida (PRWEB) April 23, 2015 ... announced that it intends to conduct a groundbreaking ... can begin to be reversed in as little ... researchers—using the science of metabolic and nutritional medicine—will ... conditions that cripple and destroy our aging brain. ...
Breaking Biology Technology:5th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 2Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 3Bayer MaterialScience Names BioAmber As Its Supplier For New Product Line - Bio-succinic acid forms backbone of innovative new bio-based polyurethanes for textiles 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3
... standard to eradicate (100% kill) in seconds ... including MRSA and ... C. ... its Ygiene(TM) Hospital Grade antimicrobial against,antibiotic-resistant microorganisms and spore forms of ...
... With First Diagnostic Test Based on Company,s, microRNA Technology, Developed by Columbia University Medical Center, ... Approved for Clinical use Acquires CLIA-certified lab to Expedite ... microRNA-based Tests, Expands Pipeline ... ...
... VNUS(R) Medical,Technologies, Inc. (Nasdaq: VNUS ) ... year 2008 guidance. The Company has recorded adjustments,to ... sheet accounts,to record additional expenses related to stock-based ... since the adoption of Statement,of Financial Accounting Standard ...
Cached Biology Technology:BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 2BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 3BioNeutral's Ygiene(TM) New Hospital Grade Disinfectant Will Save Lives and Billions of Dollars Annually at Health Care Facilities Around the World 4Rosetta Genomics Reports Second Quarter 2008 Financial Results 2Rosetta Genomics Reports Second Quarter 2008 Financial Results 3Rosetta Genomics Reports Second Quarter 2008 Financial Results 4Rosetta Genomics Reports Second Quarter 2008 Financial Results 5Rosetta Genomics Reports Second Quarter 2008 Financial Results 6Rosetta Genomics Reports Second Quarter 2008 Financial Results 7Rosetta Genomics Reports Second Quarter 2008 Financial Results 8Rosetta Genomics Reports Second Quarter 2008 Financial Results 9Rosetta Genomics Reports Second Quarter 2008 Financial Results 10Rosetta Genomics Reports Second Quarter 2008 Financial Results 11Rosetta Genomics Reports Second Quarter 2008 Financial Results 12VNUS Corrects Second Quarter 2008 Results and Revises Full Year 2008 Guidance 2VNUS Corrects Second Quarter 2008 Results and Revises Full Year 2008 Guidance 3VNUS Corrects Second Quarter 2008 Results and Revises Full Year 2008 Guidance 4
Evolutionarily conserved signaling intermediate in Toll pathway...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Anti-ADAM-12 (Meltrin Alpha); amino terminal region; rabbit host...
Biology Products: