Navigation Links
Scripps Research scientists discover a brain cell malfunction in schizophrenia
Date:12/28/2011

eractions. "While many people thought this was lost, we were able to show that indeed these interactions are preserved in post-mortem brain, allowing us to carry out these studies," said Thomas.

Compared to healthy brains, the brain samples from subjects with schizophrenia showed lower levels of acetylation in certain histone portions that would block gene expression. Another critical finding was that in younger subjects with schizophrenia, the problem was much more pronounced.

Need for New Treatment Options

Just what causes the acetylation defects among schizophrenic subjectswhat keeps certain pages of the DNA guide closedisn't clear, but from a medical perspective it doesn't matter. If researchers can reliably show that acetylation is a cause of the problem, they can look for ways to open the closed guide pages and hopefully cure or improve the condition in patients.

Thomas sees great potential. Based on the more pronounced results in younger brains, she believes that treatment with histone deacetylase inhibitors might well prove helpful in reversing or preventing the progression of the condition, especially in younger patients. Current drugs for schizophrenia tend to treat only certain symptoms, such as hallucinations and delusions, and the drugs have major side effects including movement problems, weight gain, and diabetes. If deacetylase inhibitors effectively treat a root cause of the disease and prove sufficiently non-toxic, they might improve additional symptoms and provide a major expansion of treatment options.

Interestingly, some of the cognitive deficits that plague elderly people look quite similar biologically to schizophrenia, and the two conditions share at least some brain abnormalities. So deacetylase inhibitors might also work as a treatment for age-related problems, and might even prove an effective preventive measure for people at high risk of cognitive decline based on family history or othe
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
2. Scripps Research scientists uncover new role for gene in maintaining steady weight
3. Scripps Research team finds a weak spot on deadly ebolavirus
4. Scripps research scientists develop brand new class of small molecules through innovative chemistry
5. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
6. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
7. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
8. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
9. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
10. 2 Scripps Research scientists win prestigious NIH Innovator Awards
11. Scripps Research team overcomes major obstacle for stem cell therapies and research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research scientists discover a brain cell malfunction in schizophrenia
(Date:5/5/2015)... May 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, reminds investors and media ... Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held ... The three-day conference is organized into a ... in is themed Global Fraud: Where is the Trust ...
(Date:4/20/2015)... 20, 2015 Huntington Memorial Hospital is the ... a new miniaturized, wireless monitoring sensor to manage heart ... and only FDA-approved heart failure monitoring device that has ... by physicians to manage heart failure. The ... in the pulmonary artery (PA) during a non-surgical procedure ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... breast cancer cells, according to a study published in ... just as small, or even smaller, than many blood ... healthy and sick cells, which make them interesting carriers ... In the present study, researchers from Karolinska Institutet have ...
... Nov. 7, 2013  KaloBios Pharmaceuticals, Inc. (Nasdaq: ... Phase 1 trial of KB004, an anti-EphA3 monoclonal antibody ... the 55 th American Society of Hematology (ASH) ... KB004 is a multi-center, dose-escalation study evaluating KB004 in ...
... GLENCOE, Ill. (November 7, 2013) Chicago Botanic Garden ... grant from the National Science Foundation to study the ... need to reproduce and survive. The floral scent may ... important role in the evolution and diversification of plant ...
Cached Biology News:Nanoparticles can overcome drug resistance in breast cancer cells 2KaloBios to Present KB004 Interim Phase 1 Clinical Data in Hematologic Malignancies at ASH 2KaloBios to Present KB004 Interim Phase 1 Clinical Data in Hematologic Malignancies at ASH 3KaloBios to Present KB004 Interim Phase 1 Clinical Data in Hematologic Malignancies at ASH 4KaloBios to Present KB004 Interim Phase 1 Clinical Data in Hematologic Malignancies at ASH 5NSF awards Chicago Botanic Garden $1.54 million Dimensions in Biodiversity grant 2NSF awards Chicago Botanic Garden $1.54 million Dimensions in Biodiversity grant 3NSF awards Chicago Botanic Garden $1.54 million Dimensions in Biodiversity grant 4NSF awards Chicago Botanic Garden $1.54 million Dimensions in Biodiversity grant 5
(Date:5/21/2015)... 2015 Tunnell Consulting, Inc. ... as senior statistician and Principal, a position to which ... the management and analysis of complex and large data ... , “We’re delighted to have Julia join the Tunnell ... said Dr. Philippe Cini, Group Vice President and leader ...
(Date:5/20/2015)... MECHANICSBURG, Pa. , May 20, 2015 /PRNewswire/ ... announced that the Federal Trade Commission granted early ... (HSR) Antitrust Improvements Act of 1976, as amended, ... by MJ Acquisition Corporation, a joint venture that ... XII, L.P. As previously announced, MJ ...
(Date:5/20/2015)... 20, 2015  Haemonetics Corporation (NYSE: HAE ) ... CEO, will present at The Jefferies 2015 Global Healthcare ... June 1 st , 2015 at 8:30am Eastern time.  ... presentation live via webcast at: http://wsw.com/webcast/jeff88/hae ... HAE ) is a global healthcare company dedicated to ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 ... transporter assay services for Drug-Drug Interactions (DDI), Metabolism ... Pharma, a world leader in assessing impact of ... Systems Pharmacology supported by biosimulation, announced today that ... agreement allows both companies to expand their product ...
Breaking Biology Technology:Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 3
... Forest Service Forest Products Laboratory (FPL) have joined with ... in an effort to reduce the economic costs and ... and government offices while simultaneously improving the ... 500,000 tons of bleached kraft paper, which includes the ...
... -- Astronomers from the University of Wisconsin-Madison and ... Thursday will release the first astronomical images obtained by ... telescope now equivalent to the largest optical telescope in ... the consortium that built the telescope on a remote ...
... without saying: Life often doesn't turn out as planned. ... manager in the pharmaceutical industry, really did intend to ... fulfilling career. After nearly 30 years of experience in ... and small in Connecticut, Colorado and California, Van Campen ...
Cached Biology Technology:Reducing brightness to make a better paper 2Reducing brightness to make a better paper 3Van Campen reviving UW's drug-development related education 2Van Campen reviving UW's drug-development related education 3Van Campen reviving UW's drug-development related education 4Van Campen reviving UW's drug-development related education 5Van Campen reviving UW's drug-development related education 6
This antibody is specific for human J-chain as defined by ELISA assay using purified human immunoglobulin fragments as solid phase target antigen....
Tissue-Stat ( Tissue Adherent for Mounting Formalin-Fixed and Frozen Tissue Sections.)...
Clarin Mounting Medium (Permanent environmentally safe mounting medium for general histology & cytology use)...
IHC Zinc Fixative - , 1000 ml Consult technical datasheet for details....
Biology Products: