Navigation Links
Scripps Research scientists create vaccine against heroin high
Date:7/20/2011

such as cocaine, methamphetamine, and nicotine. Human clinical trials are under way for the cocaine and nicotine vaccines.

Attempts by other researchers over the past four decades to create a clinically viable heroin vaccine, however, have fallen short, in part due to the fact that heroin is an elusive target metabolized into multiple substances each producing psychoactive effects.

An Innovative Approach

To overcome this problem, in the new study the Scripps Research team used a "dynamic" approach, targeting not only heroin itself, but also the chemical it quickly degrades into, 6-acetylmorphine (6AM), and morphine.

"Heroin is lipophilic and is rapidly degraded to 6AM," said G. Neil Stowe, a research associate in Janda's laboratory who is first author of the new study. "Both readily cross the blood-brain barrier and gain access to the opioid receptors in the brain."

The researchers linked a heroin-like hapten (a small molecule that elicits an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with Alum, an adjuvant (vaccine additive), to create a vaccine "cocktail." This mixture slowly degraded in the body, exposing the immune system to different psychoactive metabolites of heroin such as 6AM and morphine.

"Critically, the vaccine produces antibodies to a constantly changing drug target," said Stowe. "Such an approach has never before been engaged with drug-of-abuse vaccines."

To compare the results of a non-dynamic approach, the team also prepared a vaccine simply targeting morphine, a substance related to heroin. Both vaccines were then injected into rats and the effects were examined in Koob's laboratory.

Promising Results

The results showed that the rats rapidly generated robust polyclonal antibodies in response to the dynamic heroin vaccine.

In addition, the study found that addicted rats were less likely to "self-admini
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists solve mystery of nerve disease genes
2. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
3. Scripps study finds plastic in 9 percent of garbage patch fishes
4. Scripps Research Institute Scientist Knighted by Italian Republic
5. Scripps Research team sheds new light on how blood clots form
6. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
7. Scripps Research scientist wins $1.9 million grant to study malaria
8. Scripps Research scientists find way to block stress-related cell death
9. Scripps Research scientists find key mechanism in transition to alcohol dependence
10. Scripps Research scientists create new genetic model of premature aging diseases
11. Scripps Research scientists identify mechanism of long-term memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015 Genisphere announced ... to help further develop Genisphere,s therapeutics capabilities and portfolio. ... having spent much of the last 25 years in ... Bioscience, and Johnson & Johnson. Tom started his career ... Biotech Corporate Finance. He graduated from Dartmouth College with ...
(Date:6/26/2015)... 26, 2015 ATL Technology, LLC, a top provider ... in single use solutions, headquartered in Springville, Utah ... California corporation with locations in ... Jose, Costa Rica ). This acquisition will ... with ATL Technology,s existing facility in Costa ...
(Date:6/25/2015)... 2015  Imagine a tool specifically designed to help ... life. That,s exactly what USANA,s True Health Assessment ... portable health program provides a personalized approached to measuring ... your lifestyle and nutrition. At the ... night, USANA,s THA was honored with the Industry Innovation ...
Breaking Biology News(10 mins):Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2
... that could reduce the use of fertiliser in sugarcane production ... around the world and sugarcane accounts for about 80% of ... considerably above inflation over the last 30 years. This is ... is partly driven by increased global demand, and linked to ...
... University of Minnesota researchers have discovered a first-of-its-kind ... activity. The compounds present a new target for ... Complete findings are printed in today,s issue ... The compounds, known as ribonucleoside analogs 8-azaadenosine, formycin ...
... has been written and said about "platinum" open access as ... However, comparatively little has been seen of its practical implementation. ... in Zoology Deutsche Entomologische Zeitschrift and ... the future by joining the journal publishing platform of Pensoft ...
Cached Biology News:Bacteria to aid sutainable sugarcane production 2New anti-HIV drug target identified by University of Minnesota researchers 22 of the oldest German journals in Zoology go for 'platinum' open access 2
(Date:7/30/2015)...  Discovery Laboratories, Inc. (Nasdaq: DSCO ) ... $1.0M tranche under a previously awarded Phase II ... up to $3.0 million to support continued development ... potential medical countermeasure to mitigate acute and chronic/late-phase ... initial $1.0 million under this grant in October ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... for advanced fluid applications and designed for continuous operation up to 1500 bar. ... sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L homogenizer ...
(Date:7/29/2015)... PARIS , July 30, 2015 ... de la santé, publie ses résultats pour le ... Brandicourt commente les résultats. Visionner ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Au sommaire ... - Moteurs de croissance ...
(Date:7/29/2015)... , July 29, 2015 US-Australian drug ... ) today confirmed it is committed to progressing its ... soon as practicable and to ensure the Company delivers ... Executive Officer, Iain Ross , said the Company ... the lead pre-clinical programs, discovery programs and academic partnerships ...
Breaking Biology Technology:Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 2Discovery Labs Receives $1.0 million under an SBIR Grant in Continuing Support of the Development of Aerosolized KL4 Surfactant to Address Radiation-Induced Lung Injury 3GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10
... - A British court has ruled in favor of an ... Corps, Ltd. , a company the Beatles established in the 1960s ... Apple Computer, Inc. is entitled to use the apple ... Apple Corps. The dispute, which centered on a 1991 agreement, offers ...
... company that sells a wireless protection system for boats ... "off-highway" mapping software for use by hikers, campers and ... of milking system that is healthier for cows, which, ... ideas cry out "Wisconsin" to you, welcome to the ...
... Wis. - The University of Wisconsin-Milwaukee ... generated in an internal seed-funding competition. , ,The competition, ... to economic development, was conducted as part of UWM's ... provides $14 million in seed money to the winning ...
Cached Biology Technology:Apple Computer may use Apple logo on iTunes 2Business plan contest finalists reflect state's economic character 2Business plan contest finalists reflect state's economic character 3UWM announces winners of RGI awards 2
Plasmid expressing Zeocin resistance gene....
...
Hygromycin resistance gene (hph), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
... FRT-PGK-gb2-neo-FRT template is designed to allow ... The FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin ... (gb2) for expression of kanamycin resistance in ... (PGK) for expression of neomycin resistance in ...
Biology Products: