Navigation Links
Scripps Research scientists create vaccine against heroin high
Date:7/20/2011

such as cocaine, methamphetamine, and nicotine. Human clinical trials are under way for the cocaine and nicotine vaccines.

Attempts by other researchers over the past four decades to create a clinically viable heroin vaccine, however, have fallen short, in part due to the fact that heroin is an elusive target metabolized into multiple substances each producing psychoactive effects.

An Innovative Approach

To overcome this problem, in the new study the Scripps Research team used a "dynamic" approach, targeting not only heroin itself, but also the chemical it quickly degrades into, 6-acetylmorphine (6AM), and morphine.

"Heroin is lipophilic and is rapidly degraded to 6AM," said G. Neil Stowe, a research associate in Janda's laboratory who is first author of the new study. "Both readily cross the blood-brain barrier and gain access to the opioid receptors in the brain."

The researchers linked a heroin-like hapten (a small molecule that elicits an immune response) to a generic carrier protein called keyhole limpet hemocyanin or KLH, and mixed it with Alum, an adjuvant (vaccine additive), to create a vaccine "cocktail." This mixture slowly degraded in the body, exposing the immune system to different psychoactive metabolites of heroin such as 6AM and morphine.

"Critically, the vaccine produces antibodies to a constantly changing drug target," said Stowe. "Such an approach has never before been engaged with drug-of-abuse vaccines."

To compare the results of a non-dynamic approach, the team also prepared a vaccine simply targeting morphine, a substance related to heroin. Both vaccines were then injected into rats and the effects were examined in Koob's laboratory.

Promising Results

The results showed that the rats rapidly generated robust polyclonal antibodies in response to the dynamic heroin vaccine.

In addition, the study found that addicted rats were less likely to "self-admini
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists solve mystery of nerve disease genes
2. Scripps awarded $7.9 million NIH grant for research to find root cause of heart attack
3. Scripps study finds plastic in 9 percent of garbage patch fishes
4. Scripps Research Institute Scientist Knighted by Italian Republic
5. Scripps Research team sheds new light on how blood clots form
6. Scripps Research scientists awarded $2.2 million to develop treatment for multi-drug addiction
7. Scripps Research scientist wins $1.9 million grant to study malaria
8. Scripps Research scientists find way to block stress-related cell death
9. Scripps Research scientists find key mechanism in transition to alcohol dependence
10. Scripps Research scientists create new genetic model of premature aging diseases
11. Scripps Research scientists identify mechanism of long-term memory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/7/2015)... 7, 2015 Fingerprint Cards ... and FPC1035, FPC,s smallest touch fingerprint sensors to ... considered for integration on the backside of the ... increased possibilities to integrate touch fingerprint sensors in ... improves possibilities for module manufacturers to customize the ...
(Date:4/27/2015)... FORT LAUDERDALE, Fla. , Apr. 27, 2015 /PRNewswire/ ... provider of access control and security systems is pleased ... joined the company as a consultant and member of ... Bedore is widely known as a thought leader ... Socrates Distance Learning Technology Group, and has published studies ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. today ... (FIDO ® ) Alliance tm , an industry ... members commit to share technology and collaborate to ... are interoperable, more secure and private, and easier ... identity verification that protects sensitive user information and ...
Breaking Biology News(10 mins):FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... 9, 2012 A San Francisco State University biologist has ... to count bee populations and has found low numbers of ... theory that habitat loss is one of the primary reasons ... important pollinators. Now the researcher plans to add to ...
... July 10, 2012 Cylene Pharmaceuticals today announced that ... Mac) in Melbourne, Australia have established, for the first ... essential for cancer cell survival and that its inhibition ... in Cancer Cell , the findings show that ...
... Zurich, Switzerland. Research to be presented at the Annual ... Behavior (SSIB), the foremost society for research into all ... bypass surgery induces changes in the gut microbiota and ... treatment with prebiotics. Previous animal research demonstrated that ...
Cached Biology News:SF State researcher releases first results from nationwide bee count 2SF State researcher releases first results from nationwide bee count 3Cancer Cell article shows first evidence for targeting of Pol I as new approach to cancer therapy 2Gastric bypass surgery alters gut microbiota profile along the intestine 2
(Date:5/26/2015)... GERMANY (PRWEB) May 26, 2015 ... R. Grace & Co. (NYSE: GRA) announces that ... good manufacturing practice (GMP) certification from EXCiPACT™, an ... of pharmaceutical excipients. , All three ... of pharmaceutical grade excipient silica gels have now ...
(Date:5/26/2015)... BioSciences, Inc. (NASDAQ: SGMO ) announced today that ... update on the progress of Sangamo,s ZFP Therapeutic ® ... at 1:30pm ET on Monday, June 1, 2015, at the ... in New York, NY . ... via a link on the Sangamo BioSciences website in the ...
(Date:5/26/2015)... 2015 Global Stem Cells Group ... for the company’s first cellular and regenerative medicine symposium ... full day, hands-on stem cell training class Oct. 10. ... Gimenez, M.D., President of Therapeutic Confrontations (CONFTERA) in Barcelona. ... interest in regenerative medicine and recent advances in cellular ...
(Date:5/26/2015)... Pharmaco-Kinesis Corporation (PKC) announced today that its ... on the Beach in Santa Monica, CA ... Company,s innovative Metronomic Biofeedback Pump (MBP), a fully smart ... time to a target site of the human body ... in real-time.  ...
Breaking Biology Technology:CORRECTION: Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2Sangamo BioSciences Announces Presentation At The Jefferies 2015 Global Healthcare Conference 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 2Stem Cell Training, Inc. Announces First European Symposium on Cellular and Regenerative Medicine 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 2Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 4Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 5
... Pairing traditional quality,tools with innovations like ... reduce waste, meet customer expectations and stay,afloat ... Improvement Leaders,Produce Profits in Recessions, the 10th ... LLC,s GLOBAL BENCHMARKING COUNCIL,executives from leading companies ...
... Employers Across Life Sciences Industry -, ROCKLAND, Mass., ... KGaA, Darmstadt, Germany, announced today that it has been ... biotechnology and,pharmaceutical industries, ranking number 7 out of the ... honored that the scientific community has recognized EMD Serono,as ...
... Pa., Oct. 9 Environmental,Tectonics Corporation,s (Amex: ... announced the sale of three (3) additional BARA-MED(R) ... Comprehensive Healthcare Solutions, a growing company who ... throughout the,United States, has purchased a total of ...
Cached Biology Technology:Six Sigma and Social Media: Tools for Reducing Costs, Improving Processes 2EMD Serono Named as a Top Employer by Science Magazine 2Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 2Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 3Environmental Tectonics Corporation Announces a Multiple Sale of Hyperbaric Monoplace Chambers to Comprehensive Healthcare Solutions 4
... Large T antigen initiates replication ... replication in the presence of ... product can be used in ... Replication Kit cat. no. 8050. ...
NuParaffin Kit Application: Flow Cytometry Reactivity: Human...
Request Info...
...
Biology Products: