Navigation Links
Scripps Research scientists crack mystery of protein's dual function
Date:12/13/2009

cal Biology at Scripps Research, in collaboration with a member of his lab at that time, Keisuke Wakasugi.

In the 1999 paper, Wakasugi and Schimmel showed that a member of the human aminoacyl-tRNA synthetase family, tyrosyl-tRNA synthetase (TyrRS), did more than adding the amino acid tyrosine to a protein chain during protein synthesis. In addition, a fragment of the protein could function to attract immune cells and to stimulate the growth of blood vessels.

The findings were met with astonishment and some skepticism in the scientific community.

Soon afterward, however, the Schimmel lab showed that another member of the family, TrpRS, also had a dual function. In addition to its role adding the amino acid tryptophan to a protein chain during protein synthesis, a fragment of TrpRS could inhibit new blood vessel formation.

Since that time, there has been considerable therapeutic interest in TyrRS, TrpRS, and other members of the aminoacyl-tRNA synthetase family. As a pro-angiogenic factor, the TyrRS fragment could be useful in diseases where growth of blood vessels is desirable, such as in some forms of heart disease or peripheral artery disease. Likewise, the TrpRS fragment's anti-angiogenic effects could help patients reduce undesirable blood vessel growth in diseases such as cancer and a great many eye diseases that lead to catastrophic vision loss.

In fact, fragments of TrpRS were used as part of a study led by Scripps Research Professor Martin Friedlander that successfully halted the progression in animal models of highly vascular brain tumor and neovascular eye disease (PNAS 2007 104:967-972).

Despite the interest in tRNA synthetases, however, no one has been able to figure out exactly how they perform their different rolesuntil now.

Mystery Mechanism Revealed

In the current study, the research team used a combination of techniques including structural modeling analysis, mutagenesi
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team uncovers chemical basis for extra quality control in protein production
2. Scripps research scientists find new link between insulin and core body temperature
3. Scripps-led study shows ocean health plays vital role in coral reef recovery
4. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
5. Scripps studies offer new picture of Lake Tahoes earthquake potential
6. Scripps scientists help decode mysterious green glow of the sea
7. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
8. Scripps research scientists watch as individual alpha-synuclein proteins change shape
9. Scripps research team identifies key molecules that inhibit viral production
10. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
11. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... , Mar. 26, 2015 Research and Markets ... the "Global Gesture Recognition Market in Automotive Sector ... analysts forecast the Global Gesture Recognition market in Automotive ... the period 2013-2018. Gesture recognition is the ... different gestures of an individual. Gesture recognition technology can ...
(Date:3/24/2015)... NexID Biometrics LLC, whose spoof-mitigation technology boosts protection ... beginning of shipments of version 2.0 of its industry ... in Potsdam, N.Y. , is making ... here today at the Walter E. Washington Convention Center. ... boosts the accuracy rate range to 96.5 to 99.5 ...
(Date:3/23/2015)... LOS ANGELES , March 23, 2015  In ... in Federal fraud case conviction losses. This figure accounts ... fraud, which, according to The Nilson Report, exceeds $11 ... an investigative tool after a crime has occurred. Investor ... Agent and polygraph expert Joe Paolella partnered ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... severely disrupt neurotransmission and inhibit delivery of key proteins ... Laboratory (MBL) researchers have found. The particles are ... known to accumulate and form plaques in the brain ... haven,t aggregated into plaquesthese are increasingly being seen as ...
... there are many scientific works dealing solely with the ... to an infection," says Klaus Schughart, head of the ... researchers have now discovered that an excessive immune response ... in mice. This overreaction has genetic roots. The findings ...
... waters, the researchers found evidence of estrogenic compounds leaching ... more, these chemicals are potent in vivo and result ... Zealand mud snail. These findings, which show for the ... packaging materials act as functional estrogens, are published in ...
Cached Biology News:Tiny but toxic: MBL researchers discover a mechanism of neurodegeneration in Alzheimer's disease 2The host makes all the difference 2Hormone-mimics in plastic water bottles -- just the tip of the iceberg? 2
(Date:4/21/2015)... April 21, 2015 The North American chromatography systems ... from 2014 to 2019. Based on geography, this market has ... and Mexico . The U.S. accounted for ... . The major factors driving the growth of chromatography systems ... industries are the prime users of chromatography techniques. ...
(Date:4/21/2015)... 21, 2015 Research and Markets ... the "Complete 2015-16 Induced Pluripotent Stem Cell ... Stem cell research and experimentation have ... as stem cells have the unique ability to ... nature allows them to differentiate into a wide ...
(Date:4/21/2015)... Contract Research Organization XenoTech, LLC , ... a new 41,500 ft2 facility. The planned move will ... 16825 W. 116th St. in Lenexa, KS. The new ... laboratory space, will remain in the Kansas City metro area, ... than twenty years ago. Remaining in the Kansas City ...
(Date:4/21/2015)... 2015  Scientists from the J. Craig Venter ... a paper today outlining new synthetic biology methods ... The researchers, led by first author Bogumil ... Weyman , Ph.D., conclude that these new and ... genetics and thus facilitate advances in engineering these ...
Breaking Biology Technology:North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 2XenoTech Plans Expansion to New Global Headquarters after Impressive Revenue Growth in 2014 3Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 2Scientists at the J. Craig Venter Institute Publish Paper Outlining Efficient Synthetic Biology Methods to Genetically Engineer Microalgae 3
... stimulates activity in the brain. Even the mere possibility of ... the brain called the striatum. A team of Japanese researchers ... Cortex , published by Elsevier, the results of a study ... monetary task and found high-risk/high-gain options to cause higher levels ...
... , HAIKOU CITY, China, ... Amex: CPHI ), which develops,manufactures, and markets specialty pharmaceutical ... Brean Murray, Carret & Co. 2009 China,Growth Conference, to be ... York. Management is scheduled to present at 4:20 pm ...
... , ... a new market research report is available in ... Global Market Intelligence Report , ... key discipline operating on the forefront of the ...
Cached Biology Technology:Monetary gain and high-risk tactics stimulate activity in the brain 2China Pharma Holdings, Inc. to Present at Brean Murray China Growth Conference 2Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 2Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 3Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 4Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 5Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 6Reportlinker Adds Bioinformatics - A Global Market Intelligence Report 7
Agar, 5 lb. Bacteriological.Moisture: < 10%, ash: < 6.5%. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
, Premium quality synthesis and purification , You provide the sequence, we'll do the rest , Rigorous quality control , Your choice of purification method, amount and format , Available annealed...
... Clone/PAD: ZMD.414. Immunogen: Synthetic peptide derived ... and rat mTOR (Mammalian target of rapamycin ... the human mTOR protein. On Western ... ~235 kDa. Reactivity: Human (positive control: ...
...
Biology Products: