Navigation Links
Scripps Research scientists crack mystery of protein's dual function
Date:12/13/2009

LA JOLLA, CADecember 10, 2009Researchers at The Scripps Research Institute have solved a 10-year-old mystery of how a single protein from an ancient family of enzymes can have two completely distinct roles in the body. In addition to providing guidance for understanding other molecules in the family, the research supplies a theoretical underpinning for the protein's possible use for combating diseases including cancer and macular degeneration.

The research was published in the December 13, 2009 advance, online issue of the high-impact journal Nature Structural and Molecular Biology.

The scientists, led by Scripps Research Associate Professor Xiang-Lei Yang, focused on a molecule called human tryptophanyl-tRNA synthetase (TrpRS), finding that it contains a "functional switch" that enables it to perform two different functions. In one of its forms, the molecule acts to facilitate protein synthesis. In the second form, the same molecule works to inhibit the formation of new blood vesselsan effect that, if successfully harnessed, could be medically useful.

"I'm very excited about these findings," said Yang. "This piece of work provides a very deep mechanistic understanding. It has really shown that the activity of this tRNA synthetase is of biological significance and that it's a good example of the many, many different functions that have been found with the tRNA synthetase family."

One Enzyme, Two Functions

For some time, scientists have known that the aminoacyl tRNA synthetase family is composed of 20 ancient enzymes that attach the correct amino acid to a tRNA as the first step in the synthesis of proteins.

The mystery of the protein family's dual functionality, however, was born about a decade ago, with the publication of a 1999 paper in the journal Science by Paul Schimmel, who is Ernest and Jean Hahn Professor of Molecular Biology and Chemistry and a member of The Skaggs Institute for Chemi
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research team uncovers chemical basis for extra quality control in protein production
2. Scripps research scientists find new link between insulin and core body temperature
3. Scripps-led study shows ocean health plays vital role in coral reef recovery
4. Scripps Research scientists observe human neurodegenerative disorder in fruit flies
5. Scripps studies offer new picture of Lake Tahoes earthquake potential
6. Scripps scientists help decode mysterious green glow of the sea
7. Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy
8. Scripps research scientists watch as individual alpha-synuclein proteins change shape
9. Scripps research team identifies key molecules that inhibit viral production
10. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
11. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... April 17, 2014The development of stem cell therapies to ... to characterize stem cell populations based on cell surface ... a new marker that is highly expressed in a ... blood, which they describe in an article in ... Ann Liebert, Inc., publishers. The article is available free ...
(Date:4/17/2014)... A new modeling study suggests that fish consumption ... infant exposure to long-lived contaminants like persistent organic ... a team of researchers including University of Toronto ... Wania, looks at how different levels of environmental ... behavior of chemicals in the body influenced exposure ...
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... the only one of its kind in the world ... make-up of its closest endangered relatives. University of Manchester ... Leaf frogs to interbreed, producing the unique frog a ... mouth swab showed that the two parent frogs were actually ...
... have identified a single mutated gene that causes Hajdu-Cheney ... loss and osteoporosis (fragile bones). The study, published in ... possible causes of osteoporosis and highlights the gene as ... , There are only 50 reported cases of Hajdu-Cheney ...
... system developed in part by DOE,s Oak Ridge National ... the threats of insects, disease and wildfire. Led ... high-performance computing to incorporate remote sensing data from NASA ... identify abnormal vegetation patterns and the timing of seasonal ...
Cached Biology News:Unique frog helps amphibian conservation efforts 2Gene responsible for severe osteoporosis disorder discovered 2
(Date:1/15/2014)... (PRWEB) January 15, 2014 This webinar ... nonclinical and clinical safety assessment in biosimilars. , Regulatory ... for biosimilar drug development, however the complex nature of ... quality, safety and efficacy extremely challenging. Based on the ...
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Australia, Dec. 17 Phosphagenics,Limited ("Phosphagenics") (ASX: POH, ... its Phase 1 clinical trial that showed its,delivery ... skin without causing disruption or irritation of any ... be the first company to,commercialize a sustained release ...
... MOUNTAINSIDE, N.J., Dec. 17 National Stem,Cell Holding, ... company,information, financial information, quotations and press releases are,posted ... Sheets., OTCIQ is a secure, web-based portal ... to facilitate communication with the,marketplace, promote transparency, mitigate ...
... Will Enhance Quality and Speed Image Transfer at Lower ... Cost While Ensuring 21 CFR Part 11 Compliance, ... network, today announced it has been selected by,Southwest Oncology Group ... groups in the United States, to provide a,secure, 21 CFR ...
Cached Biology Technology:Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 2Phosphagenics Announces Successful Phase 1 Transdermal Oxycodone Clinical Trial Results 3National Stem Cell Holding, Inc. Posts Company and Financial Information on the OTCIQ and Has Retained New CFO and Counsel to File Registration Statement With SEC 2AG Mednet to Provide Image Network for Southwest Oncology Group 2
Rabbit polyclonal to Oct2, prediluted ( Abpromise for all tested applications). entrezGeneID: 5452 SwissProtID: P09086...
Oct 2 Immunogen: Full length human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Biology Products: