Navigation Links
Scripps Research scientist wins $1.9 million grant to study malaria
Date:6/9/2011

A scientist from The Scripps Research Institute has won a four-year, $1.9 million grant from the National Institutes of Health to better understand the parasite that causes malaria, laying the groundwork to develop better drugs to combat the widespread and deadly disease.

"Many antimalarial drugs alleviate symptoms, but do not necessarily result in a complete cure because some malaria parasites are able to persist asymptomatically in the liver for months or years," said Scripps Research Professor Elizabeth Winzeler, who is principal investigator for the new grant. "We hope to find new targets that are critical to the liver stages as well as the blood stages with the long-term aim of designing better drugs."

A Complicated Lifecycle

Malaria is a nasty and often fatal disease, affecting about 250 million people every year in Africa, Asia, and the Americas, according to the World Health Organization (WHO). Each year, more than 1 million people die of malaria, mostly children under the age of five. While significant strides had been made in curtailing the disease, for the last two decades malaria, has again been on the rise due to the emergence of drug-resistant parasites.

The parasite Plasmodium, which causes malaria, has a complicated lifecycle in two hostsmosquitoes and humans (or other vertebrate). When a malaria-infected mosquito feeds on a person, the parasite enters the human body. Within 30 minutes, the parasite has infected liver cells, where it remains anywhere from eight days to several months without causing noticeable symptoms.

When this period is over, however, the parasite (now in a different form) leaves the liver and enters red blood cells, where it grows and multiplies. When the infected red blood cells eventually burst, the parasite and Plasmodium toxins are released into the bloodstream, and the person feels sick. Symptoms include fever, chills, headache, and other flulike symptoms; in severe
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps Research scientists find way to block stress-related cell death
2. Scripps Research scientists find key mechanism in transition to alcohol dependence
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Scripps Research scientists identify mechanism of long-term memory
5. Scripps Research scientists uncover new DNA role in modifying gene function
6. Scripps Research scientists find dual switch regulates fat formation
7. Common chaperone protein found to work in surprising way, say Scripps Research scientists
8. Dr. Daniel Von Hoff presented with top genomics award from Scripps
9. Scripps Research team discovers new details about medically important protein family
10. Scripps Research scientists develop new test for pluripotent stem cells
11. Scripps Research scientists create cell assembly line
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014  Since its launch in ... of people to eliminate the pain of trying to remember ... their own biometrics fused to their smartphones. To assist people ... Labs , the company that created 1U and focuses on ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
(Date:12/19/2014)... Dec. 18, 2014 Research and Markets ( ... "iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire ... http://photos.prnewswire.com/prnh/20130307/600769 Following ... the fingerprint reading feature with the iPhone 5S. It ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3The Global Watermarking and Fingerprinting Markets 2iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2
... by a particular enzyme to modify bacterial chromosome chemistry, ... new kind of drug that could stop virulent bacterial ... in the May 6 issue of the journal Cell. ... enzyme called Dam (DNA adenine methyltransferase) plays a role ...
... early to snake attacks but not to rain , At ... still in their eggs are about to make a life-or-death ... leaf overhanging the water, has been spied by a bright ... few eggs from the clutch. , With that bite, the ...
... leading cause of blindness in older adults, yet researchers ... factors that cause this incurable disease. , But new ... a genetic link between rhesus monkeys with macular degeneration ... of the disease, when severe vision loss could still ...
Cached Biology News:Scientists take aim at virulent bacteria by decoding machinery of key control enzyme 2A whole lot of shaking goin' on triggers early hatching in red-eyed tree frogs 2A whole lot of shaking goin' on triggers early hatching in red-eyed tree frogs 3Genetic links could unlock clues to leading cause of blindness 2Genetic links could unlock clues to leading cause of blindness 3
(Date:1/22/2015)... 22, 2015  Transwestern | RBJ today announces the firm brokered ... for Shire a leading biopharmaceutical company, at Two Ledgemont Center ... Robert Richards , president, and Brian Cohen , ... entire five-floor building at 95 Hayden Ave. Photo ...
(Date:1/22/2015)... 2015 Protocol Networks brings independent technology ... of brand-neutral, independent consultants, Protocol Networks has recently announced ... over the years, his company has attracted several clients ... Plainfield, as well as others. With the success of ...
(Date:1/22/2015)... Boston, MA (PRWEB) January 22, 2015 ... systems, is pleased to announce an exciting product from a ... of motion analysis solutions over the past 15 years, with ... industries. Most recently, their 3D IMU system (inertial measurement unit), ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Selexis SA, ... mammalian Research Cell Banks (RCBs) used for drug discovery ... Cell Banks will include Next-Generation Sequencing (NGS) ... architecture de-risks biologic manufacturing by ensuring the integrity of ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 23D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... ago, we took a look at the PricewaterhouseCoopers quarterly report on ... 2003. As part of this analysis, we look at VC activity ... Midwest region. , ,This week, lets take a look at ... are any trends over time. Ready? Here we go! , ...
... and information being sent to you? Do you still manually jump from ... latest news or competitive information? Now its easier than ever to have ... RSS , often referred to as really simple syndication, is like TiVo ... from the sources you select, when you want it, in the format ...
... Bower, Co-Director of the Internet Scout Project Madison, ... Project will use a recent $2.6 million grant to ... educators access to the National Science Digital Library. , ,NSDL ... with to create a huge digital library of STEM ...
Cached Biology Technology:Though VC investing is down, reloading on new funds is rising 2Though VC investing is down, reloading on new funds is rising 3Organize the web, simply 2Scout Project plans online library portal with $2.6 million grant 2
GRADIENT MAKER, 30 ML, 1 EA. Category: Protein Vertical Instruments....
... G. Butcher (1998). • The major histocompatibility ... in the immunology area. There is great ... and in their function as antigen-presenting molecules. ... the prospect of tackling biochemical and genetic ...
DALT GRADIENT MAKER,230V, 1 EA. Category: 2D DALT Systems....
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: