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Scripps Research scientist uncovers switch controlling protein production
Date:12/22/2010

ons between different parts of the ribosomes, so if the structure of the RNA isn't correct, these conversations can't happen. And that means more mistakes, and that's not good because it can lead to any number of disease states."

For now, Karbstein said she's interested in looking at small molecules that perturb the switch, and finding out if this affects the quality of the ribosomes produced.

"Certain kinds of antibiotics work by making the ribosomes produce more mistakes it's not a huge increase but it's enough to make these cells die," she said. "Maybe we can find molecules that similarly lead to the production of 'worse' ribosomes."


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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

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