Navigation Links
Scripps Research scientist awarded $500,000 grant to study Parkinson's disease
Date:10/26/2011

JUPITER, FL, October 26, 2010 The Scripps Research Institute has been awarded a $500,000 grant by the Michael J. Fox Foundation to study a pair of genetic mutations that could lead to a new and potentially vital therapeutic target for Parkinson's disease, a progressive and fatal neurodegenerative disorder.

Philip LoGrasso, PhD, a professor in molecular therapeutics and senior director for drug discovery at Scripps Florida, is the principal investigator for the project.

The study will focus on two genes, the leucine-rich repeat kinase 2 (LRRK2) and the serum glucocorticoid-regulated kinase 1 (SGK1). Genetic testing of several thousand Parkinson's patients has shown that the risk of Parkinson's disease associated with mutations in the LRRK2 gene are substantially reduced by mutations in the SGK1 genes, bringing the risk back in line with that of the general population.

"As a kinase, LRRK2 is the kind of molecule that drugmakers have a great deal of experience targeting. And as a significant genetic contributor to Parkinson's disease, it provides important therapeutic avenues for understanding the biological mechanisms and clinical aspects of PD," said Todd Sherer, PhD, CEO of The Michael J. Fox Foundation. "Dr. LoGrasso's expertise in kinases and his well known work in developing novel treatments for Parkinson's disease will be a particularly valuable addition to the promising research already being carried out with funding from the Foundation."

SGK1 was discovered by 23andMe, Inc., a leading personal genetics company. The company currently has 125,000 genotyped customers, and nearly 90 percent have opted-in to participate in the company's Institutional Review Board-approved research. 23andMe has amassed the single largest Parkinson's research cohort in the world, which now comprises approximately 6,000 participants and includes one of the largest cohorts of individuals carrying the pathogenic mutations in the LRRK2 gene.
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... (HPV-023; NCT00518336) shows the sustained efficacy, immunogenicity ... (HPV) vaccine Cervarix. Women vaccinated with the ... than nine years, and vaccine efficacy (VE) ... the longest follow-up report for a licensed ... the full paper. , HPV and ...
(Date:7/31/2014)... news release is available in German . ... can take up gases similar to a sponge that ... suited for storing hydrogen or greenhouse gases. However, loading ... Karlsruhe Institute of Technology (KIT) now report in ... cor-rosion of the MOF surface. This can be prevented ...
(Date:7/31/2014)... photovoltaic effect in 1839, humankind has sought to further ... own purposes. In a new research report published in ... Journal , scientists may have uncovered a new ... on a naturally occurring combination of lipids that have ... time and across speciessuggests that this specific natural combination ...
Breaking Biology News(10 mins):Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3Free pores for molecule transport 2Scientists shine bright new light on how living things capture energy from the sun 2
... UCSD scientists have gained a better understanding of how ... make them healthy and resistant to vascular diseases. , ... size of a credit card to gain a better ... line arteries can make them healthy and resistant to ...
... announced that its researchers in collaboration with the Delaware ... most comprehensive analysis to date of the small RNA ... Small RNA Component of the Transcriptome," was published in ... Science. Solexa's assay can be used to elucidate small ...
... researchers have developed a customized gene chip to rapidly ... clues to prognosis in cases of neuroblastoma, a common ... genome, the microarray focuses on suspect regions of chromosomes ... a role in the cancer. , The investigators, from ...
Cached Biology News:Researchers learn how blood vessel cells cope with their pressure-packed job 2Researchers learn how blood vessel cells cope with their pressure-packed job 3Solexa and collaborating scientists illuminate the small RNA component of the transcriptome 2Customized gene chip provides rapid detection of genetic changes in children's cancer 2Customized gene chip provides rapid detection of genetic changes in children's cancer 3
(Date:7/31/2014)... for a number of breakthroughs, which altered the course ... paper, which laid the foundation of computer science, providing ... next played a pivotal role in the Second World ... codes, enabling the Allies to defeat the Nazis in ... turned his attention to artificial intelligence and proposed a ...
(Date:7/31/2014)... COLORADO SPRINGS, Colo. , July 31, 2014 ... Seed Grant awardee today with $25,000 to fund ... the Foundation,s inception in 2011, the gift was ... 11 th Annual Meeting in ... physicians who specialize in neurointerventional approaches to neurovascular ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 North Shore Towers, ... City, partnered with GI Energy, one of the nation’s leading ... $13 million upgrade of its 43-year-old CHP system. The original ... in an effort to extend the life of the plant, ... and associated electrical and heat recovery equipment, while maintaining continuous ...
(Date:7/31/2014)... 31, 2014 Senomyx , Inc. ... using proprietary taste science technologies to discover, develop, ... beverage, and ingredient supply industries, today reported financial ... ended the second quarter with $33.6 million in ... "During the past quarter Senomyx achieved another important ...
Breaking Biology Technology:A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3North Shore Towers Partners with GI Energy to Install Turnkey Natural Gas-Fired Combined Heat and Power Plant 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16
... , Introduction , ... pH-sensitive cyanine dye that is non-fluorescent at pH 7.4 and maximally ... internalization of cell surface receptors via acidic endosomal vesicles upon agonist ... the assay, the receptor can be epitope-tagged and an antibody recognizing ...
... , ... • fluorescent Western blotting • multiplex detection • dynamic range, ... The Ettan™ DIGE Imager is fully compatible with the ECL ... range as the Typhoon™ scanner. Similar results are also obtained with ...
... , , , ... toxicology • image analysis • IN Cell Analyzer, ... induction is a key characteristic of genotoxic compounds and analysis of ... chromosome segregation (aneugens) is an important component of toxicology screening of ...
Cached Biology Technology:The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR 2The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR 3The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR 4The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR 5The use of CypHer5 for receptor internalization studies in both a range of GPCRs and a non-GPCR 6Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 2Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 3Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 4Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 5Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 6Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 7Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager 8Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module 2Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module 3Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module 4Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module 5
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
Immulon 1 B 1x12 Strip, flat bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
The 891 45° Fixed Angle Rotor is designed to provide aerosol containment and can be removed from a centrifuge (seal entact) and opened under an environmental hood....
Biology Products: