Navigation Links
Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
Date:12/19/2007

dies, or "CovX-Bodies" as they were named by CovX, could also offer a general method for developing therapies against a range of diseases.

This technology represents the first time catalytic antibodies have been used in human therapy.

Building on Basic Science

Catalytic antibodiesXwhich Lerner pioneered simultaneously with Scripps Research Professor Peter Schultz, Ph.D., (then at the University of California, Berkeley) in the 1980sXare large proteins naturally produced by the immune system and found in the bloodstream.

Unlike ordinary antibodies, which recognize a wide range of foreign pathogens (such as bacteria and viruses) then alert the immune system to the presence of the invaders, catalytic antibodies recognize the transition state for chemical reactions. Catalytic antibodies can also catalyze chemical reactions, similar to enzymes.

These special properties of catalytic antibodies open the door to some interesting chemistry.

Take Barbas, Lerner, and then-postdoctoral fellow Jurgen Wagner's paper published in the December 15, 1995 (Vol. 270) issue of the journal Science, which laid the foundation for the CovX technology years later.

In the study, the scientists used a technique called reactive immunization, which enabled antibodies to catalyze reactions previously thought impossible. Specifically, the technique allowed scientists to use antibodies to catalyze carbon-carbon bond formation and to bind catalytic antibodies to antigens covalently. (In general, antibodies bind non-covalently with their substrates.)

"The key feature of the reactive immunization approach is that it allowed us to define in rather precise chemical detail the amino acids within the active site of the antibody that would perform the chemical reaction," said Barbas, adding that the antibodies the team developed with reactive immunization remain the most highly active catalysts ever made.

The paper
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. Scripps scientists discover fluorescence in key marine creature
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
4. Research shows skeleton to be endocrine organ
5. Newly created cancer stem cells could aid breast cancer research
6. Dominant cholesterol-metabolism ideas challenged by new research
7. Researchers identify proteins involved in new neurodegenerative syndrome
8. Texas researchers and educators head for Antarctica
9. MGH researchers describe new way to identify, evolve novel enzymes
10. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
11. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the addition ... report to their offering. This report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided for ...
(Date:3/17/2015)... March 17, 2015 Emotient, the leader ... today announced general availability of Emotient Analytics ... the analysis of facial expressions. The system analyzes ... content, products and services. It delivers audience response ... sentiment - as derived from facial evidence of ...
(Date:3/12/2015)... WINSTON-SALEM, N.C. , March 12, 2015 ... afternoon at Brenner Children,s Hospital, part of Wake Forest ... an outreach initiative for the 2015 ACC Men,s Basketball ... taking pictures with them and getting their autographs. ... Wake Forest Baptist. It is the only children,s hospital ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... poisonous ― but it might be used as an ... Tel Aviv University researcher claims. Prof. ... Sciences is investigating new ways for developing a novel ... of scorpions. These compounds have gone through millions of ...
... Bridget (Birgitta) of Sweden that has been kept in a ... study conducted at Uppsala University reveals that the two skulls, ... (Katarina), is not from maternally related individuals. Furthermore, dating show ... Bridget and Catherine lived. The findings are published in the ...
... will greatly benefit the U.S., say scientists in an ... of America (ESA), the nation,s largest organization of ecological ... and economic benefits of biofuel production, U.S. policies need ... ecosystems. In the report, scientists Virginia Dale, Keith ...
Cached Biology News:Pinch away the pain 2Pinch away the pain 3The putative skull of St. Bridget can be questioned 2Beyond the corn field: Balancing fuel, food and biodiversity 2
(Date:3/26/2015)... and CINCINNATI , March ... (LSE: SHP, NASDAQ: SHPG ) and Cincinnati ... broad research collaboration for rare diseases. The goal of ... therapies to treat rare diseases with high unmet ... with Cincinnati Children,s research expertise. As a nationally ...
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, ... at Align Technology, on “ Conducting Postmarket Registries - ... Global Conference and Exhibition on April 25th through April ... the poster presentation, Ale Gicqueau and Victor Chen will ... Registry, the requirements and resources to conduct the registry, ...
(Date:3/25/2015)... Optimal Research, LLC has been nominated as ... "Best Clinical Site or Trial Network". This ... selected as a nominee in this ViE award category ... distinction in 2014. The ViE awards were created to ... positive contributions of companies and individuals in the vaccine ...
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, ... which provides comprehensive capabilities for using the genome to create ... their publication of the largest studies of whole-genome data yet ... in Nature Genetics – are built ... variation, authored by a team of deCODE scientists led by ...
Breaking Biology Technology:Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 2Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 3Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 4Shire and Cincinnati Children's Establish Rare Disease Research Collaboration 5Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2
... BioSpace , the leading life sciences employment and news ... marking the 7th edition. (Logo: ... organizations across the northwestern United States and western Canada. ... printed campaign map that is promoted online ...
... 2011 Funds Will be Used ... System Designed to Drive the Widespread Adoption of ... Fight Against Infectious Disease Biocartis, a ... systems designed to drive the widespread adoption of ...
... InspireMD, Inc. (OTC BB: NSPR) ("Inspire" or the "Company"), ... commercialization of its proprietary stent platform technology, today announced ... the Company,s board of directors and the former Chairman, ... Chairman of InspireMD,s Board of Directors, effective immediately. InspireMD ...
Cached Biology Technology:BioSpace Spotlights Northwest's Life Science Community 2Biocartis Completes EUR 71 Million (USD 100 Million) Series C Fund Raising 2Biocartis Completes EUR 71 Million (USD 100 Million) Series C Fund Raising 3Biocartis Completes EUR 71 Million (USD 100 Million) Series C Fund Raising 4InspireMD Elects Sol J. Barer, Ph.D. Chairman of the Board of Directors 2InspireMD Elects Sol J. Barer, Ph.D. Chairman of the Board of Directors 3
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
... KLH-conjugated, synthetic peptide corresponding ... of human BRAF-HDAC complex protein/Lysine-specific ... Quality Assurance Routinely evaluated ... 2 years at -20°C ...
Biology Products: