Navigation Links
Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
Date:3/7/2012

LA JOLLA, CA - Scientific advances at The Scripps Research Institute have led to a new drug Surfaxin (lucinactant), approved today by the U.S. Food and Drug Administration (FDA) to treat infant respiratory distress syndrome.

"I am excited that our scientific findings will help save lives," said Charles Cochrane, MD, professor emeritus at Scripps Research. "Many years of work in our basic research laboratory at The Scripps Research Institute made this landmark development possible."

Respiratory distress syndrome (also known as neonatal respiratory distress syndrome) is a life-threatening condition affecting pre-term infants. The more premature an infant is, the more likely he or she is to suffer from it and die.

The condition occurs when infants are born prior to the time when natural surfactant is made in their lungs. Surfactant is a liquid that coats the inside of the lungs, helping to keep the air sacs open and making normal breathing possible. Without enough surfactant, the lungs collapse and the body can be starved of oxygen.

In addition to mechanical ventilation, current treatments for pre-term infants involve using surfactants derived from chopped cow or pig lungs. However, animal-derived surfactants are expensive, contain material that can be injurious to the lungs, and cannot be produced in quantities sufficient to treat pre-term infants worldwide. In addition, animal-derived surfactants can only be used once since they cause an immune reaction; in contrast, the new synthetic surfactant is not immunogenic.

The Cochrane lab first created a synthetic version of surfactant in the 1990s, mimicking a natural peptide known as Surfactant Protein B; the inventors of the technology are Cochrane and Susan Revak. After this formative work at Scripps Research, the therapy was developed by Discovery Labs of Warrington, PA, which oversaw the three phases of clinical trials required by the FDA. These clinic trials pro
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
(Date:8/25/2014)... manipulating the behavior of ants emits a cocktail ... its natural target host, but not when infecting ... findings, which suggest that the fungus "knows" its ... mechanisms underlying this phenomenon, according to researchers., "Fungi ... chemicals that affect their environment," noted lead author ...
(Date:8/25/2014)... as a lightning strike on August 12, 2014. Currently ... There are close to 2,000 personnel working on ... fires and a number of large ones. Most of ... about 100 acres. An inversion layer settled over the ... 24, keeping fire activity moderate. As the inversion lifted in ...
(Date:8/25/2014)... 25, 2014  Scribe Labs unveiled its first ... and saw its campaign surpass the $50,000 funding ... kinematic metrics that help an athlete understand how ... their running mechanics. Built with an advanced 9-axis ... most advanced set of running metrics available outside ...
Breaking Biology News(10 mins):Zombie ant fungi 'know' brains of their hosts 2Zombie ant fungi 'know' brains of their hosts 3Happy Camper and July Fire Complexes in California 2runScribe Fitness Wearable Exceeds 200% of Kickstarter Goal in First Week 2
... by the University of Colorado at Boulder and the ... liquid crystals of ultrashort DNA molecules immersed in water, ... the emergence of life on Earth. CU-Boulder ... surprisingly short segments of DNA, lifes molecular carrier of ...
... quack-quack there. Farmers may find phytochemicals to be the ... in the bucket that cashes in on the tug-o-war ... the Texas Agricultural Experiment Station. Thats because applying ... increases disease-preventing phytochemicals, or nutrients, for which consumers may ...
... in remote parts of the UK, southern Scandinavia and ... dissolved organic matter. In this weeks Nature journal (22 ... (University College London) and the US Environmental Protection Agency ... a return to a more natural, pre-industrial state following ...
Cached Biology News:Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth 2Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth 3Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth 4Old McDonald had a phytochemical 2Old McDonald had a phytochemical 3Don't judge a brook by its color -- brown waters are more natural 2
(Date:8/27/2014)... August 27, 2014 Riviera Beach, ... announcing the creation of the Sancilio Scientific Advisory ... the SCI’s philosophy of looking to nature for ... development actions are based on sound scientific data, ... Advisory Board provides a vehicle for SCI to ...
(Date:8/27/2014)... NJ (PRWEB) August 27, 2014 WriteResult, ... services – has once again shown superiority when it ... sponsor by completing the ePRO portion of their most ... The Japan-based pharma chose WriteResult’s digital writing platform ... trials – the first to complete drew data from ...
(Date:8/26/2014)... , Aug. 26, 2014 An analysis ... structures of all Mers CoV virus strains ... structures back to 2012.  This conservation and sharing of ... a Synthetic Mers CoV Blocker-Vaccine™ candidate, as it did for ... vaccine, both of which have been found to be ...
(Date:8/26/2014)... LONDON , Aug. 26, 2014 An ... gene structures of all Dengue virus strains in Pubmed, ... structures back to 1944. This conservation and sharing of ... a Synthetic Dengue Blocker-Vaccine™ candidate, as it did for ... vaccine, both of which have been found to be ...
Breaking Biology Technology:New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2
... move aside. Tiny gold stars, smaller than a billionth ... to medical diagnoses or testing for environmental contaminants. , While ... sciences, a new study by Duke University bioengineers indicates that ... above all the rest for certain applications. , The ...
... Stock Exchange Symbol: MS, EDMONTON, Nov. 6 ... developer in the treatment of multiple sclerosis (MS), ... quarter ended,September 30, 2008. BioMS Medical, in partnership ... (MBP8298), a drug for the,treatment of MS undergoing ...
... ... LymphoStat-B(R) Phase 3 trials; first Phase 3 ... in mid-2009 - ... Genome Sciences,Inc. (Nasdaq: HGSI ) today announced financial results and key developments,for the quarter ended September ...
Cached Biology Technology:Gold nanostar shape of the future 2Gold nanostar shape of the future 3BioMS Medical Announces Third Quarter 2008 Results 2BioMS Medical Announces Third Quarter 2008 Results 3BioMS Medical Announces Third Quarter 2008 Results 4BioMS Medical Announces Third Quarter 2008 Results 5Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 2Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 3Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 4Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 5Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 6Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 7Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 8Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 9Human Genome Sciences Announces Third Quarter 2008 Financial Results and Key Developments 10
... Versatile affinity matrix for the ... containing proteins or other macromolecules, Applications: ... inhibition of the interaction of pure ... protein. Removing residual SDS in 6 ...
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... forces with the Mickle Laboratory Engineering Company ... This tissue sectioning system has been designed ... experiments and to be especially applicable to ... or from small organs. Its special features ...
Biology Products: