Navigation Links
Scripps Research Scientist wins pair of grants to study critical component of memory
Date:1/5/2012

JUPITER, FL Sathyanaryanan Puthanveettil, an assistant professor on the Florida campus of The Scripps Research Institute, has been awarded a pair of notable grants to study a critical component of long-term memory formation.

Puthanveettil will receive $225,000 over three years from the prestigious Whitehall Foundation to study the role in long-term memory of a motor protein called kinesin. In this study, he will use the marine snail, Aplysia, a favorite of memory researchers because of its exceptionally large neurons and simple nervous system.

In addition to the Whitehall award, Puthanveettil has received a one-year, $100,000 grant from the Alzheimer's Drug Discovery Foundation.

Puthanveettil also plans to use the award to study kinesin, in this case to develop molecular screens to identify small molecules that can modulate kinesin function in the mammalian brain. This work will be conducted in collaboration with Scripps Research colleagues Peter Hodder, senior scientific director of lead identification, and William Roush, chemistry professor, executive director of Medicinal Chemistry, and associate dean of graduate studies at Scripps Florida.

"To be selected for an award by the Whitehall Foundation is a great honor," Puthanveettil said. "I'm also delighted with the grant from the Alzheimer's Drug Discovery Foundation, another important institution that supports the search for new therapeutics. Both awards will help advance my research substantially."

Puthanveettil has long been interested in axonal transport and its role in the molecular mechanisms underlying long-term memory storage, in particular the cellular transport of various gene products such as proteins and RNAs in the brain. In a 2008 study published in the journal Cell, Puthanveettil showed for the first time that the induction of long-term facilitationthe cellular basis of memory and learning involving enhancement of communication between neuronsrequires upregulation of specific isoform of kinesin.

Ultimately, he hopes his research will lead to an understanding of the basic pathology of various neurological disorders.

"For example, in the case of Huntington's disease, kinesin is responsible for transport of molecules that play a role in the disease," he said. "We want to know how the transport of these molecules is modified during the disease's development. Likewise for Alzheimer's diseaseif you can find a way to manipulate the transport system, you may be able to overcome some of the defects involved in the disease's pathology."


'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Scripps Research scientists discover a brain cell malfunction in schizophrenia
2. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
3. Scripps Research scientists uncover new role for gene in maintaining steady weight
4. Scripps Research team finds a weak spot on deadly ebolavirus
5. Scripps research scientists develop brand new class of small molecules through innovative chemistry
6. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
7. Scripps research team achieves critical step to opening elusive class of compounds to drug discovery
8. Scripps Research scientist awarded $500,000 grant to study Parkinsons disease
9. Scripps launches whole genome sequencing study to find root causes of idiopathic diseases
10. Scripps and Complete Genomics to collaborate on genetic research study on healthy aging
11. 2 Scripps Research scientists win prestigious NIH Innovator Awards
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Scientist wins pair of grants to study critical component of memory
(Date:5/23/2017)... robotic gym for the rehabilitation and functional motor sense evaluation of lower ... . The first 30 robots will be available from June in ... The technology was developed and patented at the IIT laboratories and has ... to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
(Date:10/9/2017)... ... October 09, 2017 , ... The ... medical marijuana products targeting the needs of consumers who are incorporating medical marijuana ... place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, The ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... genomic technologies, launched its ProxiMeta™ Hi-C metagenome deconvolution product, featuring the first ... accompanying cloud-based bioinformatics software to perform Hi-C metagenome deconvolution using their own ...
(Date:10/6/2017)... ... October 06, 2017 , ... On Tuesday, October 24th, ... INSIGhT, the first-ever adaptive clinical trial for glioblastoma (GBM). The featured speaker will ... free and open to the public, but registration is required. , WHAT: ...
Breaking Biology Technology: