Navigation Links
Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
Date:4/3/2012

h and used it as "bait" for a panel of antibodies derived from the blood of a person with chronic HCV infection. The exhaustive panning technique involves exposing this bait protein to different anti-HCV antibodies in sequence, so that the known antibody-binding sites on the complex are progressively covered until only new ones are left.

In this way, Giang catalogued 73 new anti-HCV antibodies, which bind to five distinct "antigenic regions" on the E1-E2 complex. In standard cell culture tests of HCV-neutralizing ability, several of these antibodies showed an ability to neutralize infection by a wide range of HCV strains. One, AR4A, turned out to bind to an almost-unvarying spot on E1-E2 complex, close to the surface of the virus's outer coat of fat molecules. AR4A showed significant neutralizing ability against all 22 HCV strains in a test panelnot only in tests in Law's lab, but also in confirmatory tests at the University of Copenhagen.

The new antibody thus is more broadly protective than the previous top contender, AR3A, which Law described in his 2008 Nature Medicine paper. "This human antibody AR4A has the broadest HCV-neutralizing activity known to the field," Law said.

Collaborating researchers at Rockefeller University, who recently engineered a line of HCV-infectable mice, showed that AR4A antibodies protected these mice from two widely different HCV strains. A combination of half-doses of AR3A and AR4A antibodies worked less well.

The next step for Law and his colleagues is to start making and testing prototype vaccines based on the vulnerable HCV binding sites that have been revealed by these antibody studies. The researchers also plan to use the new antibodies to study the structure and function of HCV proteins such as the all-important E1-E2 complex.

Anti-HCV antibodies such as AR4A and AR3A could have some therapeutic use, too. Although they wouldn't be able to clear existing HCV infections and wou
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
2. Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments
3. Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
4. Scripps Research alumnus wins International Science and Engineering Visualization Challenge
5. Heat and cold damage corals in their own ways, Scripps study shows
6. Scripps Research team proves plausibility of new pathway to lifes chemical building blocks
7. Scripps Research scientists provide new understanding of chronic pain
8. Scripps Research Scientist wins pair of grants to study critical component of memory
9. Scripps Research scientists discover a brain cell malfunction in schizophrenia
10. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
11. Scripps Research scientists uncover new role for gene in maintaining steady weight
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
(Date:9/29/2014)... -- Plants have a symbiotic relationship with certain ... nutrients and defend against invaders an important ... vegetables. Now, scientist have discovered that plants may ... ensuring that sprouting plants are colonized from the ... Dame, presented their findings today at the 5th ...
(Date:9/29/2014)... school? According to a new Food and Brand Lab ... can increase participation in the National School Lunch Program ... vegetables by 16%! , Chefs Move to Schools (CMTS), ... chefs with schools in order to provide nutrition instruction ... service workers. , A CMTS event was held in ...
(Date:9/29/2014)... order to support the world,s needs to make ... more, new and more efficient catalytic materials and ... including several from Wayne State University, is tackling ... grant from the National Science Foundation. , The ... Multicomponent Materials for Electrocatalytic Cascade Reactions," was to ...
Breaking Biology News(10 mins):Plants prepackage beneficial microbes in their seeds 2Chefs move to schools can increase school meal participation and vegetable intake among students 2Wayne State research aims to develop new, more efficient catalytic materials 2
... fish may be vital to saving the world,s coral reefs ... grow. A new study by researchers at the ARC ... like parrotfish and surgeonfish can only keep coral reefs clear ... a certain density, they take over entirely and the coral ...
... Institute of Medical Biology (IMB) scientists under the Agency ... part of an international team of researchers [1]who became ... behind a rare skin cancer which grows rapidly for ... published in Nature Genetics [2] today. ...
... The medical benefits of probiotics or ,friendly bacteria, are not ... a cure for stomach complaints. Yet, as more and more ... for their health benefit claims? In their new title, ... the scientific standards, the legal framework, the history of friendly ...
Cached Biology News:Weed-eating fish 'key to reef survival' 2Scientists discover cause of rare skin cancer that heals itself 2
(Date:10/1/2014)... PHILADELPHIA , October 1, 2014 ... plans to software invited to engage around the theme, ... 29-30     Elsevier ... information products and services, will host a gathering of ... discuss issues and trends impacting healthcare today and in ...
(Date:9/30/2014)... 30, 2014 Applying a well-known optical phenomenon ... Harvard University has demonstrated the ability to "paint" ... that holds promise for making future, flexible electronic ... sides of next-gen rocket ships and spacecraft with ... through oil in water, it becomes iridescent, revealing ...
(Date:9/30/2014)... Using a bio-mimicking analog of one of ... an international research team led by Alejandro Briseno ... a major step in developing long-sought polymer architecture ... for use in electronic devices. , Briseno, ... and others at Stanford University and Dresden University ...
(Date:9/30/2014)... 2014 Report Details Biosimilar drugs ... revenues Do you want to find sales potentials ... predictions for those biological drugs from 2014, helping ... financial data, R&D trends, opportunities and selling prospects. ... to 2024 at overall world market, therapeutic class, ...
Breaking Biology Technology:Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Taking thin films to the extreme 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... H. Shep Wild, President and Chief Executive Officer ... focused on the research and development of Focal ... company overview to venture capital, pharmaceutical and biotechnology ... 2011 hosted by the University of Florida Office ...
... Tissue Genesis, Inc., an emerging leader in adult ... has begun clinical trials for peripheral vascular disease (PVD) ... at the University of Louisville Hospital.  Tissue Genesis is ... patient,s own adipose-derived adult stem cells (ASCs) prepared at ...
... With its promise of superfast computers and ultrapowerful ... become one of the hottest fields in high-technology. ... to nanostructures that feature interfaces between noble metals ... of Energy (DOE),s Lawrence Berkeley National Laboratory (Berkeley ...
Cached Biology Technology:CureFAKtor Pharmaceuticals Featured at University of Florida Innovation Showcase 2011 2CureFAKtor Pharmaceuticals Featured at University of Florida Innovation Showcase 2011 3CureFAKtor Pharmaceuticals Featured at University of Florida Innovation Showcase 2011 4Tissue Genesis Begins FDA-Approved Clinical Trial 2Tissue Genesis Begins FDA-Approved Clinical Trial 3New kid on the plasmonic block 2New kid on the plasmonic block 3New kid on the plasmonic block 4New kid on the plasmonic block 5
One-step, microplate or cuvet, colorimetric 530nm, detection limit 0.16mg/dL in serum or plasma. Procedure: 10 min....
MOUSE ANTI HUMAN NPM...
Edited by D. Rickwood, T.C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolec...
...
Biology Products: