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Scripps Research Institute scientists find new calorie-burning switch in brown fat
Date:8/1/2014

this pathway, from cold-induced norepinephrine release, to upregulation of GADD45γ in brown fat cells, to the activation of ERRβ and another closely related protein, ERRγ, which turned out to be also prevalent in brown fat cells and relevant to thermogenesis. "We focused on ERRγ after that," Gantner said.

The team confirmed that the GADD45γ-mediated activation of ERRγ leads to the metabolic shift in brown fat mitochondria that is characteristic of thermogenesis. The scientists also found that transgenic mice lacking GADD45γ can't fully switch on thermogenesis under cold conditions.

In the experiments, GADD45γ acted synergistically with PGC-1α to activate brown fat cell activity. "You have to add them together to get the full effect," said Kralli, suggesting that ideally, one would stimulate both pathways to boost brown fat thermogenesis.


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Contact: Madeline McCurry Schmidt
madms@scripps.edu
858-784-9254
Scripps Research Institute
Source:Eurekalert  

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