Navigation Links
Scripps Research Institute scientists develop antidote for cocaine overdose
Date:4/18/2012

y, a stripped-down version of GNCgzkF(ab')2-gzk, which contains only the antibody's cocaine-binding segmentsreduced the mortality to zero, as well as significantly reducing overdose signs such as seizures. It also did so at a much smaller, clinically feasible dose than GNC92H2's. "There was a reversal of the signs of cocaine toxicity within seconds of the injection," said Treweek.

Janda and Treweek are now trying to find ways to produce their F(ab')2-gzk antidote economically and in large quantities. "If we can do that, then there would be no reason not to push it into clinical trials," Janda said.

He notes that such a treatment could be useful not only in reducing the immediate effects of an overdose, but also in preventing near-term relapses. "A lot of people that overdose end up going back to the drug rather quickly," Janda said, "but this antibody would stay in their circulation for a few weeks at least, and during that time the drug wouldn't have an effect on them." Likewise, this antibody could be administered to patients in addiction recovery or detox programs as a prophylactic treatment to supplement other medications, such as antidepressants, and counseling. An acute relapse during this recovery period would be immediately nullified by the antibody dose that is already in circulation.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
2. Scripps Research Institute scientists find promising vaccine targets on hepatitis C virus
3. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
4. Scripps Florida scientists awarded $3 million to develop new, more effective pain treatments
5. Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
6. Scripps Research alumnus wins International Science and Engineering Visualization Challenge
7. Heat and cold damage corals in their own ways, Scripps study shows
8. Scripps Research team proves plausibility of new pathway to lifes chemical building blocks
9. Scripps Research scientists provide new understanding of chronic pain
10. Scripps Research Scientist wins pair of grants to study critical component of memory
11. Scripps Research scientists discover a brain cell malfunction in schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute scientists develop antidote for cocaine overdose
(Date:7/30/2014)... changing climate threaten some of the world,s most ... establish seed collections to save the seeds in ... some genetic diversity., For decades, these seed collections ... a one-size-fits-all approach for how many seeds to ... regardless of species, pollination mode, growth habitat and ...
(Date:7/30/2014)... from Bjorn Brembs, professor of neurogenetics at the Institute ... figure allowing readers and reviewers to run the underlying ... important leap forward for scientific publishing, by demonstrating a ... scholarly output. , Figure 3 in fact doesn,t really ... to F1000Research , and the figure is generated ...
(Date:7/30/2014)... injury (SCI), traumatic brain injury (TBI) and peripheral nerve ... learned over the past 30 years regarding both the ... growth, but this large body of information has not ... his team from University of Miami in USA proposed ... consensus is emerging that one contributing factor is a ...
Breaking Biology News(10 mins):Saving seeds the right way can save the world's plants 2F1000Research brings static research figures to life 2
... Hagfish is a strange animal: it feeds by gnawing its way ... 3 days. Scientists at the University of British Columbia (Canada) believe ... inside the carcass to become acidic from the build up of ... is able to cope with environmental conditions of up to 7% ...
... to a low-weight preemie at 24 weeks, exhibited the first-found ... and the amniotic fluid of a woman in preterm labor. ... cannot be cultured and grown in the lab, researchers from ... Department of Obstetrics and Gynecology at MetroHealth Medical Center in ...
... Dr. Peter Sarnow and a team of Stanford University scientists ... named miR-122, in order to replicate in cultured liver cells. ... amount of hepatitis C virus RNA was reduced by approximately ... potential to develop new antiviral agents against hepatitis C, the ...
Cached Biology News:Prenatal nicotine exposure reduces breathing response of newborns... 2Prenatal nicotine exposure reduces breathing response of newborns... 3
(Date:7/30/2014)... Hartford, CT (PRWEB) July 30, 2014 ... economic development organization based in East Hartford, Conn., was ... on Phase II of a project that will determine ... facility in rural north-central Connecticut. USDA Rural Development provided ... (RBEG) program for the second phase of the feasibility ...
(Date:7/30/2014)... Arlington, MA (PRWEB) July 30, 2014 ... products, announces completion of its first round of seed ... round will enable preliminary efforts to develop a novel ... the support of our investors and their commitment to ... CEO of LayerBio. "Ophthalmology is one of many areas ...
(Date:7/29/2014)... The advanced optical methods and applications for ... a revolution in the neurosciences were the inspiration behind ... SPIE, the international society for optics and photonics ... of the BRAIN Initiative in the United States, and ... vision for and provide examples of the impact that ...
(Date:7/29/2014)... foam of atom-thick sheets can be made to any ... Rice University. , In microscopic images, the foam ... and walls that reinforce each other. The structure consists ... of graphene oxide that self-assemble with the assistance of ... the foam could find use in structural components, as ...
Breaking Biology Technology:USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 2USDA Grant Funds Second Phase of Bio-Energy Research Community Economic Development in CT 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4Tough foam from tiny sheets 2
... 2012  Argos Therapeutics Inc., today announced that it ... AGS-003-006, a Phase 2 study of its Arcelis™ ... with advanced renal cell carcinoma (RCC). The results ... T cell responses and overall survival. AGS-003 in ...
... DIEGO, Jan. 31, 2012  bioTheranostics, Inc., a bioMerieux ... drive personalized treatment, has introduced a new product ... resistance and pathway interrogation called PRECIS Precision Medicine ... cancer management, partners accurate diagnosis of primary tumor ...
... science world, with the potential to create foldaway mobile phones, ... new finding at the University of Manchester gives graphene,s potential ... for distilling alcohol. In a report published in ... shows that graphene-based membranes are impermeable to all gases and ...
Cached Biology Technology:Argos Therapeutic Arcelis™ Immunotherapy AGS-003 in Combination With Sunitinib Shows Statistically Significant Correlation of Immune System Response to Overall Survival in Phase 2 Study in Patients with Advanced Renal Cell Carcinoma (RCC) 2Argos Therapeutic Arcelis™ Immunotherapy AGS-003 in Combination With Sunitinib Shows Statistically Significant Correlation of Immune System Response to Overall Survival in Phase 2 Study in Patients with Advanced Renal Cell Carcinoma (RCC) 3bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 2bioTheranostics Launches Precision Medicine Biomarkers for Tumor Pathway Interrogation 3Supermaterial goes superpermeable 2
Multi-enzyme complex containing a wide range of carbohydrases, including arabanase, cellulase,b-glucanase, hemi-cellulase and xylanase Patent/trademark/license (electronic): A product of Novozyme Cor...
... Biotin Streptavidin-HRP Systems provide rapid, precise ... antigens in frozen or paraffin-embedded tissue, ... systems also facilitate double or triple ... performed simultaneously with primary antibodies of ...
Miscellaneous: Versatile stain for staining RNA (bluish-purple), DNA (blue), proteins (red) and acid polysaccharides Assay: ~ 95 % Suitab tst: differential staining of nucleic acids and prote...
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
Biology Products: