Navigation Links
Scripps Research Institute chemists discover structure of cancer drug candidate
Date:5/19/2014

LA JOLLA, CA May 19, 2014 Chemists at The Scripps Research Institute (TSRI) have determined the correct structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials in cancer patients.

The new report, published this week by the international chemistry journal Angewandte Chemie, focuses on a compound called TIC10.

In the new study, the TSRI scientists show that TIC10's structure differs subtly from a version published by another group last year, and that the previous structure associated with TIC10 in fact describes a molecule that lacks TIC10's anticancer activity.

By contrast, the correct structure describes a molecule with potent anticancer effects in animals, representing a new family of biologically active structures that can now be explored for their possible therapeutic uses.

"This new structure should generate much interest in the cancer research community," said Kim D. Janda, the Ely R. Callaway Jr. Professor of Chemistry and member of the Skaggs Institute for Chemical Biology at TSRI.

Antitumor Potential

TIC10 was first described in a paper in the journal Science Translational Medicine in early 2013. The authors identified the compound, within a library of thousands of molecules maintained by the National Cancer Institute (NCI), for its ability to boost cells' production of a powerful natural antitumor protein, TRAIL. (TIC10 means TRAIL-Inducing Compound #10.)

As a small molecule, TIC10 would be easier to deliver in a therapy than the TRAIL protein itself. The paper, which drew widespread media coverage, reported that TIC10 was orally active and dramatically shrank a variety of tumors in mice, including notoriously treatment-resistant glioblastomas.

Tumors can develop resistance to TRAIL, but Janda had been studying compounds that defeat this resistance. The news about TIC10 therefore got h
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scripps Florida scientists reveal molecular secrets behind resveratrols health benefits
2. Scripps Florida scientists find connection between gene mutation, key symptoms of autism
3. Microscopic organism plays a big role in ocean carbon cycling, Scripps scientists discover
4. Scripps Research Institute scientists provide new grasp of soft touch
5. Scripps Florida scientists offer best practices nutrition measurement for researchers
6. NIH grants up to $28 million to group led by Scripps Research for work on ebola treatment
7. Scripps Wellderly Genome Resource now available to researchers
8. New probes from Scripps research quantify folded and misfolded protein levels in cells
9. Scripps scientist awarded $1.8 million to develop new approaches to lung cancer therapy
10. Scripps Florida scientists offer new insight into neuron changes brought about by aging
11. Scripps leads first global snapshot of key coral reef fishes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Research Institute chemists discover structure of cancer drug candidate
(Date:8/5/2015)... According to a new market research report, ... (BFSI, Airport, IT & Telecom, Utilities, Education, Defense & ... published by MarketsandMarkets, defines and segments the Physical Identity ... global PIAM Market is estimated to grow from $272.2 ... a CAGR of 14.9 % from 2014 to 2019. ...
(Date:8/4/2015)... (NASDAQ: AMRI ) today reported financial and operating results for ... , Second quarter contract revenue of $ 85.2 ... Adjusted contract margins of 26 % , ... in EPS from royalties in the current quarter , ... are very pleased to present another strong financial quarter, with all ...
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... The University of Utah is launching a six-year, $21.5 ... materials for uses ranging from faster computers and communications devices ... Center of Excellence in Materials Research and Innovation is being ... grant from the National Science Foundation (NSF), $6.5 million for ...
... reversible adhesives; tenaciously clinging barnacles; and surfaces that rub ... topics that will be presented at the AVS 58th ... place Oct. 30 - Nov. 4, 2011, at the ... press registration to journalists; see details below. Journalists may ...
... Three leading sci-tech experts described engineering trends for ... this summer at the Directors Guild in Los ... of Sciences (NAS) Science & Entertainment Exchange to ... and scientists that engage the public in television, ...
Cached Biology News:$21.5 million for materials research at the University of Utah 2$21.5 million for materials research at the University of Utah 3Media invited: AVS 58th International Symposium and Exhibition 2Media invited: AVS 58th International Symposium and Exhibition 3Media invited: AVS 58th International Symposium and Exhibition 4Media invited: AVS 58th International Symposium and Exhibition 5IEEE-USA/NAS Hollywood Forum describes engineering trends for entertainment industry professionals 2
(Date:8/26/2015)... CA. (PRWEB) , ... August 26, 2015 , ... ... conferences to develop new business relationships with local sponsors in southern California. The Clinical ... facilitate their drug development processes and regulatory pathways., , ...
(Date:8/25/2015)... SHANGHAI , Aug. 25, 2015   WuXi ... open-access R&D capability and technology platform company serving the ... Holdings Ltd. ("Lee,s Pharm," Hong Kong Exchange Stock Code: ... Hong Kong with 20 years of operations ... the two companies have signed an agreement whereby WuXi,s ...
(Date:8/25/2015)... ... August 25, 2015 , ... Vets ... in Knapp, Wis. The company has added a AS16 Sharples centrifuge to harvest ... collection during bacterial or fungal fermentation process development. , The new centrifuge ...
(Date:8/25/2015)... ... August 25, 2015 , ... One of the world’s foremost authorities on ... Bindiya Vakil, has been on a mission for the past two weeks. She’s been ... operations - from the two massive explosions that occurred on August 12 at the ...
Breaking Biology Technology:PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 2WuXi PharmaTech to Be Exclusive Supplier of Laboratory Testing Services to Lee's Pharm 3New centrifuge and fermentor expand product development capacity at Vets Plus 2Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 2Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 3Resilinc Supply Chain Expert Warns: Impact of Tianjin Chemical Explosions Will be Far Worse than Reported 4
... 24 /PRNewswire-Asia-FirstCall/ --, -- Q4 FY 2009 Revenues increased 43.2% ... to $2.2 Million with diluted EPS of $0.08, -- FY ... Increased 32.4% to $7.9 Million vs. FY08 with diluted EPS ... 124.8% to $8.3 Million, -- June 30, 2009 Cash and ...
... , , , ABBOTT PARK, ... third-quarter 2009 financial results on Wednesday, Oct. 14, 2009, before the market opens. ... a live webcast of the earnings conference call at 8 a.m. Central time ... at www.abbottinvestor.com. An archived edition of the call will be available after ...
... ... completed a $25 million round of funding. Participating investors included CTTV Investments LLC, ... Lightspeed Venture Partners. , ... South San Francisco, CA (PRWEB) September 24, 2009 -- LS9, Inc., the Renewable ...
Cached Biology Technology:Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 2Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 3Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 4Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 5Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 6Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 7Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 8Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 9Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 10Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 11Tianyin Pharmaceutical Co., Inc. Reports Record Fiscal 2009 Financials With $7.9 Million in Net Income 12LS9 Secures $25 Million in Latest Round of Funding 2LS9 Secures $25 Million in Latest Round of Funding 3
We offer solid and solution phase peptide synthesis including a whole range of modifications. Please send the details of your peptide synthesis need to info@rpeptide.com...
... Expansion Kit - Monolayer is a system designed ... a monolayer in a serum-free environment. The kit ... which has been optimized for neural stem cell ... Genes & Development 10 :3129). Human fibroblast ...
... I from E. coli is ... enzyme also contains both 5'--3'and ... exonuclease activity enables the enzyme ... in the DNA as starting ...
... containing an overproducing clone of M-MLV Reverse ... the polymerization of DNA using template DNA, ... large mRNAs, >10 kb, may be synthesized. ... RNase H activity than AMV Reverse Transcriptase ...
Biology Products: