Navigation Links
Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
Date:11/9/2011

SAN FRANCISCO (Nov. 9, 2011; 12:50 p.m.) Late breaking clinical trial results from testing of cangrelor, an investigational intravenous antiplatelet, showed patients can be "bridged" from the time that their physicians stop their oral antiplatelet drugs until they undergo cardiac surgery. Study results demonstrated cangrelor maintained target levels of platelet inhibition known to be associated with a low risk of thrombotic events, such as stent thrombosis, vs. placebo. The BRIDGE Trial results were presented here today at the Cardiovascular Research Foundation (CRF) annual Transcatheter Cardiovascular Therapeutics (TCT) conference.

"Patients with coronary stents require drugs that block platelets that can stick to their stents and cause clots. When these patients require surgery, the oral drugs must be stopped days in advance to wear off and reduce the risk of surgical bleeding; however, this puts them at an increased risk of thrombotic events," said Eric Topol, MD, cardiologist and chief academic officer at Scripps Health and BRIDGE Trial primary investigator. "With nothing available that blocks platelets and then goes away quickly, we are between the rock of thrombosis and the hard place of surgical bleeding."

BRIDGE results showed 99 percent of cangrelor-treated patients maintained target levels of platelet inhibition for all time points measured over the bridging period compared to 19 percent of placebo patients (p<0.001). The primary safety measure demonstrated no significant excess in surgical bleeding complications (data below).

The results were presented by Dominick J. Angiolillo, MD, PhD, medical director, cardiovascular research program at the University of Florida College of Medicine Jacksonville, "BRIDGE results support the hypothesis that intravenous cangrelor may be a feasible and well tolerated management strategy in patients who require prolonged platelet P2Y12 inhibition after thienopyridine discontinuation pr
'/>"/>

Contact: Rebecca Hollins
rebecca.hollins@themedco.com
973-290-6081
The Medicines Company
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps research team solves structure of beneficial virus
2. Scripps research team sheds light on immune system suppression
3. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
4. Scripps research scientists identify compounds for stem-cell production from adult cells
5. Scripps research scientists identify blood component that turns bacteria virulent
6. Scripps research team defines new painkilling chemical pathway
7. Dolphin population stunted by fishing activities, Scripps/NOAA study finds
8. Scripps Research scientists shed light on how DNA is unwound so that its code can be read
9. Scripps scientists develop first examples of RNA that replicates itself indefinitely
10. Scripps scientists create first crystal structure of an intermediate particle in virus assembly
11. Historical photographs expose decline in Floridas reef fish, new Scripps study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
(Date:9/21/2014)... the University of California, San Diego, have developed a ... control the activity of genes based on sequences of ... its application to human embryonic cells in a paper ... , "All of our cells have the same blueprint, ... John Whitaker, lead author of the report. "Skin cells ...
(Date:9/21/2014)... -- Shellfish such as mussels and barnacles secrete very ... ship hulls, even underwater. Inspired by these natural adhesives, ... that could be used to repair ships or help ... new waterproof adhesives, the MIT researchers engineered bacteria to ... proteins as well as a bacterial protein found in ...
(Date:9/19/2014)... today by researchers from several Harvard University labs ... experienced and aspiring researchers with the intellectual raw ... made from soft, flexible materials. , With the ... other advances in manufacturing technology, soft robotics is ... drawn from conventional rigid robot design, but working ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2Engineered proteins stick like glue -- even in water 2Engineered proteins stick like glue -- even in water 3Soft robotics 'toolkit' features everything a robot-maker needs 2
... Not only land birds, but also some seabirds, ... example, circumnavigates the earth one and a half times ... about the migratory behaviour of seabirds as compared with ... Planck Institute for Ornithology have studied the migratory behaviour ...
... In a paradigm changing discovery, Plasmodium vivax ( ... historically thought to be resistant to the disease, those who ... red blood cells, according to researchers from Case Western Reserve ... of Health. In a study of more than 600 individuals ...
... experimental oral drug has lowered blood sugar levels and inflammation ... could someday be added to the arsenal of drugs used ... research. The drug consists of a synthetic molecule that ... inhibitory factor, or MIF. This protein is implicated in a ...
Cached Biology News:To the Antarctic or Brazil for new feathers 2To the Antarctic or Brazil for new feathers 3Duffy-negative blood types no longer protected from P. Vivax malaria 2Duffy-negative blood types no longer protected from P. Vivax malaria 3Study points to potential new drug for type 2 diabetes 2Study points to potential new drug for type 2 diabetes 3Study points to potential new drug for type 2 diabetes 4
(Date:9/22/2014)... 2014 Follow us on ... young has groomed and nurtured anti-aging products and ... emphasis on appearance maintenance is benefitting the market ... protein obtained from the bacterium, Clostridium Botulinum, which ... relaxation. With cosmetic indications for botulinum toxin ranging ...
(Date:9/22/2014)... 22, 2014 FierceBiotech today announced its ... biotechnology companies of 2014. FierceBiotech editors John Carroll ... this year’s winners. Those selected are identified as ... the industry. , "It's always a lot ... Fierce 15 companies," said Carroll. "This year in particular ...
(Date:9/22/2014)... Sept. 22, 2014  Spherix Incorporated (SPEX) -- an intellectual ... intellectual property, today announced that the United States Patent & ... in the month of September that is part of a ... patent is: USRE45,121 , Application number: US 13/728,867 ... date: Dec 27, 2012 The listed inventors ...
(Date:9/20/2014)... 2014 HealthTronics, Inc. , ... radiology products and services, has signed a distribution ... Clinicon Corporation for its high precision laser ... minimally invasive, mobile, surgical technology—offering more choices for ... agreement, HealthTronics will make available Clinicon’s FDA-cleared SureLase™ ...
Breaking Biology Technology:Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 2Strong Demand for Non-Invasive Cosmetic Procedures Drives the Global Botulinum Toxin Market, According to New Report by Global Industry Analysts, Inc. 3FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 2HealthTronics Announces Distribution Agreement with Clinicon-Laser Surgical Device Expands Minimally Invasive, Mobile Technology Portfolio 3
... on Thursday announced that three Wisconsin businesses would receive ... Commerce Technology Assistance Grant (TAG) and Technology Venture Fund ... , Functional Biosciences, Inc. , is a ... It will receive a $250,000 TVF loan for work ...
... ads on their round, shiny stomachs as part of "tummy ... To some, this is "desperate branding" in action. , ... spot on the list of branding failures. These projects are ... weird processes. , ,Roy Disney said, "You need branding when ...
... summer. Business slows. Indeed, in Europe, where I find myself ... animation that will last until the first of September. People ... grasp weakens. , ,Or does it? , ,After a rare ... mountain in my inbox and a to-do list that had ...
Cached Biology Technology:A final word on branding 2A final word on branding 3A final word on branding 4A final word on branding 5Leaving it all behind 2
... The Holten MaxiSafe 2010 Class II ... ergonomical working condition of comfort while ... efficiency and performance.,Refined operator, environment and ... both exhausted and recirculated air.,Bottom filters ...
... Jouan MSC series of Class II ... conditions and certification to the world's ... ensures that the cabinets cannot be ... Natural lighting, low noise and arm ...
... Stand-96 is designed for paramagnetic bead precipitation ... ml PCR plates with no additional accessories. ... in a standard SBS 96-well microplate footprint. ... magnets guarantees easy and fast (as little ...
... circular clear acrylic chamber for complete visibility ... features microprocessor operation for precise mixing capability. ... Carousel rotates at 11 rpm; manufactured ... , Bottle Capacity - four 35 ...
Biology Products: