Navigation Links
Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
Date:2/24/2012

JUPITER, FL A Scripps Florida team has been awarded nearly $1.5 million by the National Institutes of Health to identify and develop novel potent inhibitors of the human immunodeficiency virus (HIV), the cause of AIDS.

A. Donny Strosberg, a professor on the Florida campus of The Scripps Research Institute, is the principal investigator for the new three-year study.

Current treatments of HIV-infected patients are based on combinations of drugscalled cocktailsthat target several critical key steps in the early and late stages of the viral replication cycle. While these combinations have proven effective in controlling the infection in many patients, the continuous emergence of new multi-resistant viral strains requires the development of new classes of drugs that can be aimed at different targets on HIV.

Strosberg's target is the capsid protein or CA, the primary component of the HIV virionthe infectious particle responsible for transporting the viral genome to host cells. This viral protein forms a cone-shaped shell around the HIV genome, and plays a critical role in the lifecycle of the virus by packaging and organizing the viral genome so that HIV can replicate efficiently.

"Because of the growing resistance of HIV against current treatments, a new, differently targeted approach to treating the disease is urgently needed," Strosberg said. "We expect to use the HIV capsid protein as a new high-throughput screening target for the discovery of novel anti-HIV/AIDS agents."

Identifying new compounds that could target the CA protein might make it possible to prevent the protein's assembly into capsid shells in the first place, blocking the virus's infectivity, and adding a potent complement to existing treatments, he said. This strategy has worked well for Strosberg's group, which has in the past years discovered several potent inhibitors of the hepatitis C virus.

Strosberg and his colleagues, who include Susana Valente, PhD, an assistant professor at Scripps Florida, and Massimo Caputi, PhD, an associate professor of biomedical science at the Florida Atlantic University Charles E. Schmidt College of Medicine, plan to perform an initial screening of some 350,000 compounds in the Molecular Libraries Probe Centers Network at Scripps Research; Scripps Research is one of only four such large probe centers nationwide.


'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Related biology news :

1. Scripps Research alumnus wins International Science and Engineering Visualization Challenge
2. Heat and cold damage corals in their own ways, Scripps study shows
3. Scripps Research team proves plausibility of new pathway to lifes chemical building blocks
4. Scripps Research scientists provide new understanding of chronic pain
5. Scripps Research Scientist wins pair of grants to study critical component of memory
6. Scripps Research scientists discover a brain cell malfunction in schizophrenia
7. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
8. Scripps Research scientists uncover new role for gene in maintaining steady weight
9. Scripps Research team finds a weak spot on deadly ebolavirus
10. Scripps research scientists develop brand new class of small molecules through innovative chemistry
11. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... ... made significant investments in recruiting top industry experts, and expanding its LATAM network ... provides industry-leading tools for clients to manage their clinical trial projects. , The ...
(Date:4/27/2016)... ... , ... Shimadzu Scientific Instruments (SSI) will be showcasing a ... and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for potency, ... by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC testing, ...
(Date:4/27/2016)... British Columbia , April 27, 2016 /PRNewswire/ ... oder "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( ... im Anschluss an ihre Pressemitteilung vom 13. August ... erhalten hat, ihre Finanzen um zusätzliche 200.000.000 Einheiten ... 4.000.000 Kanadische Dollar zu bringen. Davon wurden 157.900.000 ...
(Date:4/27/2016)... ... April 27, 2016 , ... NDA Partners Chairman ... as an Expert Consultant. Mr. Clark was formerly a Vice President with ... of small molecule monographs based on analytical methods. NDA Partners Expert Consultants ...
Breaking Biology Technology: