Navigation Links
Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
Date:2/24/2012

JUPITER, FL A Scripps Florida team has been awarded nearly $1.5 million by the National Institutes of Health to identify and develop novel potent inhibitors of the human immunodeficiency virus (HIV), the cause of AIDS.

A. Donny Strosberg, a professor on the Florida campus of The Scripps Research Institute, is the principal investigator for the new three-year study.

Current treatments of HIV-infected patients are based on combinations of drugscalled cocktailsthat target several critical key steps in the early and late stages of the viral replication cycle. While these combinations have proven effective in controlling the infection in many patients, the continuous emergence of new multi-resistant viral strains requires the development of new classes of drugs that can be aimed at different targets on HIV.

Strosberg's target is the capsid protein or CA, the primary component of the HIV virionthe infectious particle responsible for transporting the viral genome to host cells. This viral protein forms a cone-shaped shell around the HIV genome, and plays a critical role in the lifecycle of the virus by packaging and organizing the viral genome so that HIV can replicate efficiently.

"Because of the growing resistance of HIV against current treatments, a new, differently targeted approach to treating the disease is urgently needed," Strosberg said. "We expect to use the HIV capsid protein as a new high-throughput screening target for the discovery of novel anti-HIV/AIDS agents."

Identifying new compounds that could target the CA protein might make it possible to prevent the protein's assembly into capsid shells in the first place, blocking the virus's infectivity, and adding a potent complement to existing treatments, he said. This strategy has worked well for Strosberg's group, which has in the past years discovered several potent inhibitors of the hepatitis C virus.

Strosberg and his colleagues, who include Su
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research alumnus wins International Science and Engineering Visualization Challenge
2. Heat and cold damage corals in their own ways, Scripps study shows
3. Scripps Research team proves plausibility of new pathway to lifes chemical building blocks
4. Scripps Research scientists provide new understanding of chronic pain
5. Scripps Research Scientist wins pair of grants to study critical component of memory
6. Scripps Research scientists discover a brain cell malfunction in schizophrenia
7. Scripps Florida scientist awarded $3.4 million for HIV/AIDS research
8. Scripps Research scientists uncover new role for gene in maintaining steady weight
9. Scripps Research team finds a weak spot on deadly ebolavirus
10. Scripps research scientists develop brand new class of small molecules through innovative chemistry
11. Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida team awarded nearly $1.5 million to develop potent new HIV inhibitors
(Date:7/10/2014)... genus Axinaea belongs to the large, mainly tropical ... ca. 5000 species in the family rely on bees for ... by other insects or vertebrates. The flowers of Axinaea ... flowers and the petals of the different species are pink, ... out based on the contrasting colours of their bulbous appendages. ...
(Date:7/10/2014)... Imagine the open ocean as a microbial megacity, teeming ... drop of water, hundreds of types of bacteria can ... of these ocean microbes have their own daily cyclesnot ... to wake up, commute, work, and eat at the ... sun. Light-loving photoautotrophsbacteria that need solar energy to help ...
(Date:7/10/2014)... company housed at NJIT,s business incubator, received a $1.4 ... surgeons will use to staunch bleeding during brain surgery. ... site, and the natural bio-polymer solutions in the gel ... 30 seconds. , The gel can shorten an ... into less time for the patient,s skull to be ...
Breaking Biology News(10 mins):Novel type of bird pollination mechanism discovered in South America 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3A start-up at NJIT develops bleeding-control gel for brain surgery 2
... you ever met a cat that doesn't go crazy over ... the world don't respond to it at all, according to ... of Chemical & Engineering News, the weekly newsmagazine published by ... Catnip sensitivity is inherited, says Carolyn M. McDaniel, a veterinarian ...
... Florida researchers say they are a step closer to ... cancers before symptoms become apparent. , The findings, currently ... Sciences, involve introducing molecularly engineered strands of DNA into ... burst after they adhere to cancer proteins. , ...
... the gene responsible for controlling a first key step in ... in the journal Nature tomorrow (Thursday 27 October 2005). , ... take place once a sperm enters an egg, giving it ... reproducing animals. , The absence or mutation of this gene ...
Cached Biology News:Many cats unaffected by catnip, C&EN reports 2Scientists closer to new cancer detection method 2Scientists closer to new cancer detection method 3Scientists unpick genetics of first 15 minutes of life 2
(Date:7/10/2014)... 2014 Robert Harman, DVM, Founder and CEO ... proud to announce the relaunch of his highly informative blog, ... series called “ What are Stem Cells ?” Dr. ... straightforward foundation in the basics of stem cell therapy so ... right type of treatment when considering regenerative medicine. , A ...
(Date:7/10/2014)... July 10, 2014 Senior supply chain ... professional associations, addressed the challenges of “Reducing Cost, Lead ... Industries” through strategic sourcing. Describing the partnership of the ... Supply Chain Management Institute ( SCMI) of the ... June 24 at the Kroc Institute of Peace and ...
(Date:7/10/2014)... July 10, 2014  Kainos Capital, a firm specializing ... announced that it has acquired the Slim-Fast brand from ... business. Terms of the transaction were not disclosed. ... replacement business that markets ready-to-drink shakes, powders, bars and ... and in the United Kingdom ...
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
Breaking Biology Technology:Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Kainos Capital Acquires Slim-Fast From Unilever 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... - Oncothyreon Inc. (Nasdaq: ONTY ) (TSX:ONY), ... therapeutic products for the treatment of cancer, today announced ... year end 2009 financial results on Wednesday, August 12, ... markets. Following the release, Oncothyreon,s management expects to discuss ...
... HARBIN, China, Aug. 6 /PRNewswire-Asia-FirstCall/ -- ... "the Company") (Nasdaq: CSKI ), a leading,fully ... of China ("PRC"), today announced the appointment of Mr.,William ... Board of Directors,("the Board") effective August 4, 2009. Mr. ...
... /PRNewswire-FirstCall/ - AEterna Zentaris Inc. (NASDAQ: AEZS ... endocrine therapy and oncology, today announced that its President ... overview at the upcoming Canaccord Adams 29th Annual Global ... p.m. (eastern time) at the Intercontinental Hotel in Boston. ...
Cached Biology Technology:China Sky One Medical, Inc. Appoints New Independent Director 2China Sky One Medical, Inc. Appoints New Independent Director 3
Collected from 8-12 week old New Zealand or Californian rabbits. Aseptically collected and processed to minimize hemolytic activity. Pricing: $60/unit for 1 - 10 units...
Donor Goat Serum...
GeneRacer is an advanced RACE (rapid amplification of cDNA ends) technique that improves the efficiency of amplifying full-length 5' and 3' cDNA ends. With the GeneRacer Kit you can:...
One-step, microplate or cuvet, colorimetric, linear detection range 0.7 mg/dL to 35 mg/dL. Procedure: 5 min....
Biology Products: