Navigation Links
Scripps Florida scientists show 'lifeless' prions capable of evolutionary change and adaptation
Date:12/31/2009

JUPITER, FL Scientists from The Scripps Research Institute have determined for the first time that prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, are capable of Darwinian evolution.

The study from Scripps Florida in Jupiter shows that prions can develop large numbers of mutations at the protein level and, through natural selection, these mutations can eventually bring about such evolutionary adaptations as drug resistance, a phenomenon previously known to occur only in bacteria and viruses. These breakthrough findings also suggest that the normal prion protein which occurs naturally in human cells may prove to be a more effective therapeutic target than its abnormal toxic relation.

The study was published in the December 31, 2009 issue of the journal Science Express, an advance, online edition of the prestigious journal Science.

"On the face of it, you have exactly the same process of mutation and adaptive change in prions as you see in viruses," said Charles Weissmann, M.D., Ph.D., the head of Scripps Florida's Department of Infectology, who led the study. "This means that this pattern of Darwinian evolution appears to be universally active. In viruses, mutation is linked to changes in nucleic acid sequence that leads to resistance. Now, this adaptability has moved one level down to prions and protein folding and it's clear that you do not need nucleic acid for the process of evolution."

Infectious prions (short for proteinaceous infectious particles) are associated with some 20 different diseases in humans and animals, including mad cow disease and a rare human form, Creutzfeldt-Jakob disease. All these diseases are untreatable and eventually fatal. Prions, which are composed solely of protein, are classified by distinct strains, originally characterized by their incubation time and the disease they cause. Prions have the ability to reproduce, d
'/>"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Scripps scientists discover fluorescence in key marine creature
2. Scripps research team blocks bacterial communication system to prevent deadly staph infections
3. Scripps scientists develop new tests that identify lethal prion strains quickly and accurately
4. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
5. Scripps expedition provides new baseline for coral reef conservation
6. Bright lights: Mystery of glowing antibody solved by Scripps research scientists
7. Fishing throws targeted species off balance, Scripps study shows
8. Scripps Oceanography Research pegs ID of red tide killer
9. Scripps Research Institute awarded patent for remarkable chemical technology
10. Scripps research scientists reveal key structure from ebola virus
11. Scripps study sets high economic value on threatened Mexican mangroves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... University researchers have completed a 20-year study that ... prairie at different times of the year. It ... spring time frame has no measurable negative consequences ... multiple benefits. , The study was conducted by ... Biological Station fire chief, and Joseph Craine, research ...
(Date:7/31/2014)... to loud noise alters how the brain processes ... sounds, according to neuroscientists at The University of ... this week in Ear and Hearing , ... hearing loss affects the brain,s recognition of speech ... corners of the population, affecting an estimated 15 ...
(Date:7/31/2014)... Oren Tessler, Assistant Professor of Clinical Surgery at LSU ... part of a team of plastic and reconstructive surgeons ... to screen and select patients for a specific surgical ... who underwent this surgery to decompress the nerves that ... cosmetic eyelid surgery. The study, which confirms the benefit ...
Breaking Biology News(10 mins):Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3UT Dallas study reveals effect of loud noises on brain 2Surgeons report significant migraine relief from cosmetic eyelid surgery technique 2
... UTRECHT, The Netherlands, September 10 , ... Powers Privacy-Enhancing Biometric,Technology , WCC ... search,and match software, today announced its collaboration with priv-ID, ... anonymity for,the user. The collaboration will provide enhanced identification ...
... , , , , ... leader in fingerprint identity and authentication solutions, today announced that ... fingerprint sensor as an option on NCR,s next-generation integrated point-of-sale (POS) ... The fingerprint sensor, which is embedded in the top ...
... , , BEDFORD, ... ), a global provider of imaging and biometrics software, today ... development services to Lockheed Martin,s high-performance fingerprint card scanning service. ... Martin a five-year, $47 million contract to continue managing the ...
Cached Biology News:WCC Smart Search & Match and Priv-ID Announce Global Collaboration 2WCC Smart Search & Match and Priv-ID Announce Global Collaboration 3NCR Embeds DigitalPersona U.are.U(R) 4500HD Fingerprint Sensor in New NCR RealPOS(TM) 70XRT Point-of-Sale Workstations 2Aware Software and Development Services Enable State-of-the-Art Fingerprint Card Scanning 2Aware Software and Development Services Enable State-of-the-Art Fingerprint Card Scanning 3
(Date:7/31/2014)... and even the entire body to visualize long-range connections ... been a long-time dream of biologists. A study published ... journal Cell has now made that dream ... bodies, and human tissue biopsies transparent, while keeping the ... the way for a better understanding of brain-body interactions, ...
(Date:7/31/2014)... July 31, 2014 The SNIS Foundation ... $25,000 to fund a translational research project.  The ... the gift was presented at the Society of ... in Colorado Springs, CO. ... approaches to neurovascular conditions, SNIS formed the SNIS ...
(Date:7/31/2014)... 31, 2014 Graphite Metallizing Corporation announces ... oven carts. These bearings are uniquely suited to prevent ... bearings because of the high temperatures . , ... from the design engineers at Graphite Metallizing to overcome ... During their manufacturing operation, pans containing blocks of powder ...
(Date:7/31/2014)... 31, 2014 Research and Markets ... Market 2014-2018" report to their offering. ... the study of the genetic material or genomes of ... basis for the discovery and development of diagnostic and ... health conditions. Genomics is supported by three major product ...
Breaking Biology Technology:See-through organs and bodies will accelerate biomedical discoveries 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 2SNIS Foundation Bestows First Grant Award For Cutting-Edge NeuroInterventional Research 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2
... SYDNEY, Australia, Oct. 3 /Xinhua-PRNewswire-FirstCall/ --,Pharmaceutical company Pharmaxis ... present 12 abstracts from its respiratory disease,program at ... held,in Berlin from the 4th to the 8th ... top respiratory researchers and clinicians to hear latest,advances ...
... 2 Alba Therapeutics Corporation today,announced the promotions of ... Mark Ginski, PhD, and Kate Huber. "We are pleased,to ... and we are,fortunate to have such a fine group ... for unmet medical needs of patients with celiac,disease, asthma, ...
... FOR LEAD DRUG CANDIDATE ARIKACE(TM) DRIVES,CONTINUED CLINICAL EXPANSION, ... Inc., a,biopharmaceutical company focused on developing innovative inhaled,pharmaceuticals ... announced that it has secured a $12.5 million ... Company LLC, an affiliate of Horizon,Technology Finance Management ...
Cached Biology Technology:Pharmaxis Research Programs Highlighted at European Respiratory Society Congress 2Pharmaxis Research Programs Highlighted at European Respiratory Society Congress 3Alba Therapeutics Corporation Announces Promotions 2Alba Therapeutics Corporation Announces Promotions 3Alba Therapeutics Corporation Announces Promotions 4Transave, Inc. Secures $12.5 Million in New Financing 2Transave, Inc. Secures $12.5 Million in New Financing 3Transave, Inc. Secures $12.5 Million in New Financing 4Transave, Inc. Secures $12.5 Million in New Financing 5
... Y2 Receptor antiserum This NPY Y2 ... level and is currently being characerized in brain. ... and mouse and appears to work better on ... rat. For full characterizarion in dorsal root ganglion ...
RECK (F-20)...
Black Polypropylene 384 Round Well Plate 70/Box...
... 1 Peroxiredoxin (Prx) is a ... have been known to connect with ... isoforms (about 50 proteins), collected in ... homology, particularly amino-terminal region containing active ...
Biology Products: