Navigation Links
Scripps Florida scientists reveal molecular secrets behind resveratrol's health benefits
Date:4/29/2014

JUPITER, FL, April 29, 2014 Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now identified one of the molecular pathways that resveratrol uses to achieve its beneficial action. They found that resveratrol controls the body's inflammatory response as a binding partner with the estrogen receptor without stimulating estrogenic cell proliferation, which is good news for its possible use as a model for drug design.

The study was recently published as an accepted manuscript in the online journal eLife, a publication supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.

"Estrogen has beneficial effects on conditions like diabetes and obesity but may increase cancer risk," said Kendall Nettles, a TSRI associate professor who led the study. "What hasn't been well understood until now is that you can achieve those same beneficial effects with something like resveratrol."

The problem with resveratrol, Nettles said, is that it really doesn't work very efficiently in the body. "Now that we understand that we can do this through the estrogen receptor, there might compounds other than resveratrol out there that can do the same thingonly better," he said.

"Our findings should lead scientists to reconsider the estrogen receptor as a main target of resveratroland any analogues," said Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory. "It has gotten swept under the rug."


'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. Scripps Florida scientists find connection between gene mutation, key symptoms of autism
2. Microscopic organism plays a big role in ocean carbon cycling, Scripps scientists discover
3. Scripps Research Institute scientists provide new grasp of soft touch
4. Scripps Florida scientists offer best practices nutrition measurement for researchers
5. NIH grants up to $28 million to group led by Scripps Research for work on ebola treatment
6. Scripps Wellderly Genome Resource now available to researchers
7. New probes from Scripps research quantify folded and misfolded protein levels in cells
8. Scripps scientist awarded $1.8 million to develop new approaches to lung cancer therapy
9. Scripps Florida scientists offer new insight into neuron changes brought about by aging
10. Scripps leads first global snapshot of key coral reef fishes
11. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists reveal molecular secrets behind resveratrol's health benefits
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/5/2017)... , April 5, 2017 Today HYPR ... that the server component of the HYPR platform is ... providing the end-to-end security architecture that empowers biometric authentication ... HYPR has already secured over 15 million users across ... manufacturers of connected home product suites and physical access ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... SomaGenics announced the receipt of a Phase ... (Single Cell), expected to be the first commercially available ... from single cells using NGS methods. The NIH,s recent ... development of approaches to analyze the heterogeneity of cell ... for measuring levels of mRNAs in individual cells have ...
(Date:10/9/2017)... FL (PRWEB) , ... October 09, 2017 , ... The ... scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. ... industry is faced with the challenge of how to continue to feed a growing ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
Breaking Biology Technology: