Navigation Links
Scripps Florida scientists reveal molecular secrets behind resveratrol's health benefits
Date:4/29/2014

JUPITER, FL, April 29, 2014 Resveratrol has been much in the news as the component of grapes and red wine associated with reducing "bad cholesterol," heart disease and some types of cancer. Also found in blueberries, cranberries, mulberries, peanuts and pistachios, resveratrol is associated with beneficial health effects in aging, inflammation and metabolism.

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now identified one of the molecular pathways that resveratrol uses to achieve its beneficial action. They found that resveratrol controls the body's inflammatory response as a binding partner with the estrogen receptor without stimulating estrogenic cell proliferation, which is good news for its possible use as a model for drug design.

The study was recently published as an accepted manuscript in the online journal eLife, a publication supported by the Howard Hughes Medical Institute, the Max Planck Society and the Wellcome Trust.

"Estrogen has beneficial effects on conditions like diabetes and obesity but may increase cancer risk," said Kendall Nettles, a TSRI associate professor who led the study. "What hasn't been well understood until now is that you can achieve those same beneficial effects with something like resveratrol."

The problem with resveratrol, Nettles said, is that it really doesn't work very efficiently in the body. "Now that we understand that we can do this through the estrogen receptor, there might compounds other than resveratrol out there that can do the same thingonly better," he said.

"Our findings should lead scientists to reconsider the estrogen receptor as a main target of resveratroland any analogues," said Jerome C. Nwachukwu, the first author of the study and a research associates in the Nettles laboratory. "It has gotten swept under the rug."


'/>"/>

Contact: Eric Sauter
esauter@scripps.edu
267-337-3859
Scripps Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. Scripps Florida scientists find connection between gene mutation, key symptoms of autism
2. Microscopic organism plays a big role in ocean carbon cycling, Scripps scientists discover
3. Scripps Research Institute scientists provide new grasp of soft touch
4. Scripps Florida scientists offer best practices nutrition measurement for researchers
5. NIH grants up to $28 million to group led by Scripps Research for work on ebola treatment
6. Scripps Wellderly Genome Resource now available to researchers
7. New probes from Scripps research quantify folded and misfolded protein levels in cells
8. Scripps scientist awarded $1.8 million to develop new approaches to lung cancer therapy
9. Scripps Florida scientists offer new insight into neuron changes brought about by aging
10. Scripps leads first global snapshot of key coral reef fishes
11. Scripps Research Institute scientists achieve most detailed picture ever of key part of hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists reveal molecular secrets behind resveratrol's health benefits
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016   Boston Biomedical , ... compounds designed to target cancer stemness pathways, announced ... granted Orphan Drug Designation from the U.S. Food ... gastric cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin ... to inhibit cancer stemness pathways by targeting STAT3, ...
(Date:6/23/2016)... SPRING, Md. , June 23, 2016 A ... collected from the crime scene to track the criminal down. ... and the U.S. Food and Drug Administration (FDA) uses DNA ... Sound far-fetched? It,s not. The ... genome sequencing to support investigations of foodborne illnesses. Put as ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: