Navigation Links
Scripps Florida scientists identify critical 'quality control' for cell growth
Date:7/5/2012

JUPITER, FL, July 5, 2012 Scientists from the Florida campus of The Scripps Research Institute have identified a series of intricate biochemical steps that lead to the successful production of proteins, the basic working units of any cell.

The study, which appears in the July 6, 2012 edition of the journal Cell, sheds light on the assembly of a structure called the ribosome, a large and complex protein-producing machine inside all living cells. Ribosomes are the targets of many commercially used antibiotics and represent a promising area of research because of the importance of ribosome assembly and function for cell growth. There are well-established links between defects in ribosome assembly and cancer, making this pathway a potential new target for anti-cancer drugs.

"With important cellular machines like ribosomes, it makes sense that some process exists to make sure things work correctly," said Katrin Karbstein, a Scripps Research associate professor who led the study. "We've shown that such a quality control function exists for ribosomal subunits that use the system to do a test run but don't produce a protein. If the subunits don't pass, there are mechanisms to discard them."

Protein Production Line

As part of the protein-production process called "translation," the ribosome decodes information carried in messenger RNA (mRNA) to produce a proteina chain of amino acids.

To produce mature, functioning ribosomal RNAs (rRNAs), the body first makes precursor rRNAs that can be processed into mature ones. In human cells, this is done in two stagesthe first occurs in the nucleolus, a protein-nucleic acid structure inside the nucleus, and finally in the cytoplasm, the basic cellular stew where protein translation occurs.

In the cytoplasm, these pre-mature ribosomal subunits encounter large pools of mature subunits, messenger RNA, and numerous assembly factors and translation factors that he
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
Scripps Research Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Scripps Research Institute Scientists Develop Alternative to Gene Therapy
2. Scripps Research Institute announces five-year research collaboration with Bristol-Myers Squibb
3. Esther B. OKeeffe Foundation gives $2 million to the Scripps Research Institute
4. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
5. Plastic trash altering ocean habitats, Scripps study shows
6. Scripps Florida scientists identify neurotranmitters that lead to forgetting
7. Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach
8. Scripps research scientists find anticonvulsant drug helps marijuana smokers kick the habit
9. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
10. Scripps Research Institute scientists develop antidote for cocaine overdose
11. Scripps Research Institute Professor Gerald F. Joyce elected to American Academy of Arts & Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scripps Florida scientists identify critical 'quality control' for cell growth
(Date:8/27/2014)... century-old museum specimens hold clues to how global climate change ... kill trees and the news is not good. , ... and maple trees in warmer urban areas, which raises the ... says Dr. Elsa Youngsteadt, a research associate at NC State ... "More scale insects would be a problem, since scales can ...
(Date:8/26/2014)... Louis have developed algorithms to identify weak spots in ... The technology, which needs to be refined before it ... minor strains and tiny injuries in the body,s tissues ... available online Aug. 27 in the Journal of ... the nexus of the physical and life sciences. , ...
(Date:8/26/2014)... of harmful bacteria, biofilms make the treatment of ... biofilm pose a significant health risk due to ... biofilm-protected bacteria account for some 80 percent of ... to 1,000 times more resistant to antibiotics than ... have stumbled onto a magic bullet," said David ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... , Journal of Visualized Experiments , details the ... polymer, SurgiLux, was developed by scientists at the University ... from chitin, which is found in fungal cell walls ... allows SurgiLux to form low energy bonds between the ...
... Institute for Medical Research has been awarded a $1 ... which is administered by the National Institute for Occupational ... for Disease Control and Prevention (CDC), the National Institute ... comprehensively study the overall physical, mental and socioeconomic impact ...
... Manoel Manghi from Toulouse University in France and his colleagues ... to a double stranded molecule of DNA when it is ... be published in EPJ E . Instead of using ... settings, the authors focused on using a theoretical model to ...
Cached Biology News:New bio-adhesive polymer demonstrated in JoVE 2Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders 2
(Date:8/26/2014)... , Aug. 26, 2014 Albany Molecular ... that William S. Marth , President and Chief ... Stanley Global Healthcare Conference on Monday, September 8, 2014 ... audio webcast of the presentation can be accessed at ... The webcast will be archived for 90 ...
(Date:8/26/2014)... Boston, MA (PRWEB) August 26, 2014 ... to manage core research facilities , the ... of Kansas Cancer Center have chosen iLab Solutions' ... and effectively increase productivity. , "We are ... Center and KU Cancer Center signed on with ...
(Date:8/26/2014)... Historically, drug development has faced ... to grow – high attrition rate, low productivity, ... high regulatory hurdles and increasing concern about ... that the traditional business model of pharmaceutical companies ... seeking to find better ways to reduce operational ...
(Date:8/26/2014)... 2014 Spartan Bioscience today announced ... of Business Development. Mr. Shah is responsible for ... System in the United States and international ... opportunities and strategic initiatives for the company’s rapid ... Mr. Shah was the Global Marketing Product Manager ...
Breaking Biology Technology:The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 2The University of Kansas Medical Center and The University of Kansas Cancer Center Select iLab Solutions Web-based Software to Streamline Operations 3Transitioning from Bench into Clinical Phase, new webinar hosted by Xtalks 2Spartan Bioscience Names Charudutt Shah as Director of Business Development 2
... today announced that Pat Basu, M.D., M.B.A. , ... as Chief Medical Officer. Dr. Basu has just completed ... a White House Fellow, America,s most prestigious and selective ... will play a critical role in advancing vRad,s efforts, ...
... Sequenom, Inc. (NASDAQ: SQNM ), a life ... the launch of its iPLEX ADME PGx panel developed ... distribution, metabolism, and excretion (ADME). This Research Use Only ... polymorphisms (SNP), insertions and deletions (INDELS) and copy number ...
... HILL, MA -- Boston College researchers have discovered two ... chemical vapor deposition, finding a disorderly tangle of tube ... nanoscopic tubes, according to a report in the latest ... using a thin layer of catalyst, Professor of Physics ...
Cached Biology Technology:vRad Adds White House Fellow, Dr. Pat Basu, to Its Leadership Teams 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 2Sequenom Introduces iPLEX® ADME PGx Panel on MassARRAY® System 3Boston College Researchers discover 2 early stages of carbon nanotube growth 2
... can be induced prior to DNA purification ... stability of single-copy BACs with the high ... vectors. The kits provide the linearized vector ... screening system) necessary to create a 10X ...
...
... 3T3 cells were cultured in DMEM with 4 ... of growth. In order to keep the ... in acetone-methanol. The cells are arrayed on ... each wells surface specifically treated to enhance cellular ...
... Systems provide rapid, precise localization of ... frozen or paraffin-embedded tissue, cytospins and ... facilitate double or triple labeleing experiments, ... with primary antibodies of different animal ...
Biology Products: